Mechanism of small heat shock protein function in vivo: a knock-in mouse model demonstrates that the R49C mutation in alpha A-crystallin enhances protein insolubility and cell death
about
Temperature-dependent structural and functional properties of a mutant (F71L) αA-crystallin: molecular basis for early onset of age-related cataractDifferentiation of Induced Pluripotent Stem Cells to Lentoid Bodies Expressing a Lens Cell-Specific Fluorescent ReporterCrystal Structure of an Activated Variant of Small Heat Shock Protein Hsp16.5Protein homeostasis: live long, won't prosperIn vivo substrates of the lens molecular chaperones αA-crystallin and αB-crystallinTranscriptional regulation of mouse alpha A-crystallin gene in a 148kb Cryaa BAC and its derivatesAlphaA-crystallin R49Cneo mutation influences the architecture of lens fiber cell membranes and causes posterior and nuclear cataracts in mice.The small heat-shock protein HspL is a VirB8 chaperone promoting type IV secretion-mediated DNA transferLens fiber cell differentiation and denucleation are disrupted through expression of the N-terminal nuclear receptor box of NCOA6 and result in p53-dependent and p53-independent apoptosis.αA-Crystallin associates with α6 integrin receptor complexes and regulates cellular signaling.Cat-Map: putting cataract on the mapAltered chaperone-like activity of alpha-crystallins promotes cataractogenesis.A knock-in mouse model for the R120G mutation of αB-crystallin recapitulates human hereditary myopathy and cataracts.Different alpha crystallin expression in human age-related and congenital cataract lens epithelium.Small heat shock proteins and α-crystallins: dynamic proteins with flexible functions.A novel mutation in CRYAA is associated with autosomal dominant suture cataracts in a Chinese familyDifferential role of arginine mutations on the structure and functions of α-crystallin.Mechanism of insolubilization by a single-point mutation in alphaA-crystallin linked with hereditary human cataracts.p62 expression and autophagy in αB-crystallin R120G mutant knock-in mouse model of hereditary cataract.Molecular chaperones as regulators of cell death.Lens aging: effects of crystallins.The transcription factor Pax6 regulates survival of dopaminergic olfactory bulb neurons via crystallin αA.In vivo lens deficiency of the R49C alphaA-crystallin mutant.The Cataract-linked Mutant Connexin50D47A Causes Endoplasmic Reticulum Stress in Mouse Lenses.Quantitative biometric phenotype analysis in mouse lenses.Hydroimidazolone modification of human alphaA-crystallin: Effect on the chaperone function and protein refolding ability.Autophagy and UPR in alpha-crystallin mutant knock-in mouse models of hereditary cataractsActivation of the unfolded protein response by a cataract-associated αA-crystallin mutation.Role of cysteine residues in the enhancement of chaperone function in methylglyoxal-modified human alpha A-crystallin.Probing the changes in gene expression due to α-crystallin mutations in mouse models of hereditary human cataract.
P2860
Q24297386-731F0A88-DE91-422A-9F74-CB4F879E9233Q27339294-6CBED417-1BBE-4E6D-ADA6-6AC371AB2242Q27679512-D4BC8674-93A7-48AB-BC29-DC6232A7CCC7Q28281856-13CE7249-6C99-465C-A550-3F4CB8EC3A49Q28538157-BD4551D6-5E60-478D-BE7C-CFD1CF7C1E05Q33370677-158E1243-F40F-4964-A83F-BEC018C6C424Q33484430-451966E9-BEDE-45E8-A08B-E523F5645597Q33924232-B5F5C58E-24C5-4C4F-A58F-608F86EF4E17Q33992575-49D43D18-3E24-479C-B94B-38F33A73EA8DQ34233267-83FA7E72-B55A-4FB1-B682-9085001A9953Q34248597-5533C50E-EE87-4518-B756-B34C49C1554DQ34412852-292C9AAB-5BE5-4171-832C-5DA4C2937AE5Q34699001-57FEDC70-A890-485D-A7EF-8043B1D73B35Q36032845-12F47DC5-0207-4DAC-84EA-4CD7AEAC4611Q36287203-1EBC94D0-DDC9-49EA-8157-0B9C84C2827DQ36499609-1017903D-1C31-4E1F-AAD3-FD5255AF73C1Q37021424-DB2F724F-9957-44DF-AC92-FB48B285B1F7Q37097757-39EC612A-65C2-474F-9453-46E4874D02F9Q37227740-2853BEA2-89ED-435F-8D74-5E5C03FA99B7Q37310205-6F2A788B-E8B0-4B25-8C23-70B47BA32F0AQ37346358-96543204-6A1C-40EE-84C3-A8FE7EE219ACQ38339204-98C758C4-E1B0-4F3D-82CD-51B5942764FDQ40640833-15EC89EF-BEF3-4144-9F57-0E9509D0376DQ41046056-B9FDA44B-5FE5-478D-86D2-28F80AD28B4FQ41497487-752D10BF-AFF4-4DCC-B0A3-D2DA2DA21EAEQ41911286-B4E983F1-09BE-4D5D-A925-52E58CD68100Q42121573-1830CE65-E40B-4C0C-BCD4-50F7E003B91DQ42408572-28DAE44F-FAAE-4E5E-9D76-B144BE0C4A17Q42935346-B7EEBAF7-2856-4BEE-8EBD-7642E6A70B64Q47714691-FD49F17B-00C9-4865-AFE6-C1FEA9F02F9D
P2860
Mechanism of small heat shock protein function in vivo: a knock-in mouse model demonstrates that the R49C mutation in alpha A-crystallin enhances protein insolubility and cell death
description
2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2008
@ast
im Februar 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/02/29)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/02/29)
@nl
наукова стаття, опублікована в лютому 2008
@uk
name
Mechanism of small heat shock ...... in insolubility and cell death
@ast
Mechanism of small heat shock ...... in insolubility and cell death
@en
Mechanism of small heat shock ...... in insolubility and cell death
@nl
type
label
Mechanism of small heat shock ...... in insolubility and cell death
@ast
Mechanism of small heat shock ...... in insolubility and cell death
@en
Mechanism of small heat shock ...... in insolubility and cell death
@nl
prefLabel
Mechanism of small heat shock ...... in insolubility and cell death
@ast
Mechanism of small heat shock ...... in insolubility and cell death
@en
Mechanism of small heat shock ...... in insolubility and cell death
@nl
P2093
P2860
P921
P3181
P356
P1476
Mechanism of small heat shock ...... in insolubility and cell death
@en
P2093
Jing-hua Xi
Julia Gross
R Reid Townsend
P2860
P304
P3181
P356
10.1074/JBC.M708704200
P407
P577
2007-12-05T00:00:00Z