Synpolydactyly in mice with a targeted deficiency in the HoxD complex
about
Conservation and divergence of regulatory strategies at Hox Loci and the origin of tetrapod digitsRegulation of number and size of digits by posterior Hox genes: A dose-dependent mechanism with potential evolutionary implicationsSynpolydactyly phenotypes correlate with size of expansions in HOXD13 polyalanine tractNovel HOXA13 mutations and the phenotypic spectrum of hand-foot-genital syndromeDeletions in HOXD13 segregate with an identical, novel foot malformation in two unrelated families.Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD clusterA 117-kb microdeletion removing HOXD9-HOXD13 and EVX2 causes synpolydactylyMutations in HOXD13 underlie syndactyly type V and a novel brachydactyly-syndactyly syndromeUncoupling time and space in the collinear regulation of Hox genesDistinct roles and regulations for HoxD genes in metanephric kidney developmentHuman HOX gene mutationsLimb malformations and the human HOX genesMouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression"Self-regulation," a new facet of Hox genes' functionModeling chromosomes in mouse to explore the function of genes, genomic disorders, and chromosomal organizationReconstructing the history of human limb development: lessons from birth defects.Homeobox genes d11-d13 and a13 control mouse autopod cortical bone and joint formation.Deletion of a HoxD enhancer induces transcriptional heterochrony leading to transposition of the sacrum.Genetic disorders of the skeleton: a developmental approachControlled somatic and germline copy number variation in the mouse modelPosterior Hox gene expression in developing genitalia.A nonsense mutation in the HOXD13 gene underlies synpolydactyly with incomplete penetrance.Large scale transgenic and cluster deletion analysis of the HoxD complex separate an ancestral regulatory module from evolutionary innovations.Reshuffling genomic landscapes to study the regulatory evolution of Hox gene clusters.Mechanisms of Hox gene colinearity: transposition of the anterior Hoxb1 gene into the posterior HoxD complex.Evidence for regulation of cartilage differentiation by the homeobox gene Hoxc-8.Molecular anatomy of the developing limb in the coquí frog, Eleutherodactylus coquiInducing segmental aneuploid mosaicism in the mouse through targeted asymmetric sister chromatid event of recombinationA genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limbBreakpoints around the HOXD cluster result in various limb malformations.A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locusMutant Hoxd13 induces extra digits in a mouse model of synpolydactyly directly and by decreasing retinoic acid synthesis.Genetic enhancement of limb defects in a mouse model of Cornelia de Lange syndrome.Molecular basis for skeletal variation: insights from developmental genetic studies in mice.Point mutation of Hoxd12 in mice.An interdigit signalling centre instructs coordinate phalanx-joint formation governed by 5'Hoxd-Gli3 antagonism.Fork stalling and template switching as a mechanism for polyalanine tract expansion affecting the DYC mutant of HOXD13, a new murine model of synpolydactyly.The molecular basis of human congenital limb malformations.2q31.1 microdeletion syndrome: case report and literature review.John Saunders' ZPA, Sonic hedgehog and digit identity - How does it really all work?
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P2860
Synpolydactyly in mice with a targeted deficiency in the HoxD complex
description
1996 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Nature
@fr
artículu científicu espublizáu en 1996
@ast
scientific journal article
@en
vedecký článok (publikovaný 1996/11/07)
@sk
vědecký článek publikovaný v roce 1996
@cs
wetenschappelijk artikel (gepubliceerd op 1996/11/07)
@nl
наукова стаття, опублікована в листопаді 1996
@uk
مقالة علمية (نشرت في 7-11-1996)
@ar
name
Synpolydactyly in mice with a targeted deficiency in the HoxD complex
@ast
Synpolydactyly in mice with a targeted deficiency in the HoxD complex
@en
Synpolydactyly in mice with a targeted deficiency in the HoxD complex
@nl
type
label
Synpolydactyly in mice with a targeted deficiency in the HoxD complex
@ast
Synpolydactyly in mice with a targeted deficiency in the HoxD complex
@en
Synpolydactyly in mice with a targeted deficiency in the HoxD complex
@nl
prefLabel
Synpolydactyly in mice with a targeted deficiency in the HoxD complex
@ast
Synpolydactyly in mice with a targeted deficiency in the HoxD complex
@en
Synpolydactyly in mice with a targeted deficiency in the HoxD complex
@nl
P921
P3181
P356
P1433
P1476
Synpolydactyly in mice with a targeted deficiency in the HoxD complex
@en
P2093
P2888
P3181
P356
10.1038/384069A0
P407
P577
1996-11-07T00:00:00Z
P6179
1003514079