Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption
about
Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptorMolecular and functional properties of P2X receptors--recent progress and persisting challengesPolymorphisms in the P2X7 receptor gene are associated with low lumbar spine bone mineral density and accelerated bone loss in post-menopausal womenP2X7 receptors regulate multiple types of membrane trafficking responses and non-classical secretion pathwaysThe role of purinergic receptors in stem cell differentiationPurinergic signalling in boneInsights into the Molecular Mechanisms Underlying Mammalian P2X7 Receptor Functions and Contributions in Diseases, Revealed by Structural Modeling and Single Nucleotide PolymorphismsPhysiological mechanisms and therapeutic potential of bone mechanosensing.P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesisP2X7 nucleotide receptors mediate blebbing in osteoblasts through a pathway involving lysophosphatidic acidShockwaves induce osteogenic differentiation of human mesenchymal stem cells through ATP release and activation of P2X7 receptors.Novel data point to a broader mechanism of action of oxidized ATP: the P2X7 receptor is not the only targetReduced bone turnover in mice lacking the P2Y13 receptor of ADP.Loss of P2X7 nucleotide receptor function leads to abnormal fat distribution in mice.P2Y2 receptors regulate osteoblast mechanosensitivity during fluid flow.Hyperglycemia-induced Renal P2X7 Receptor Activation Enhances Diabetes-related Injury.Gain and loss of function of P2X7 receptors: mechanisms, pharmacology and relevance to diabetic neuropathic pain.In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1 beta in the murine brainOscillating fluid flow activation of gap junction hemichannels induces ATP release from MLO-Y4 osteocytes.Activation of extracellular-signal regulated kinase (ERK1/2) by fluid shear is Ca(2+)- and ATP-dependent in MC3T3-E1 osteoblastsNon-synonymous single nucleotide polymorphisms in the P2X receptor genes: association with diseases, impact on receptor functions and potential use as diagnosis biomarkersTrophic activity of human P2X7 receptor isoforms A and B in osteosarcoma.Activation of the transcription factor FosB/activating protein-1 (AP-1) is a prominent downstream signal of the extracellular nucleotide receptor P2RX7 in monocytic and osteoblastic cells.Caveolin-1 regulates P2X7 receptor signaling in osteoblastsSecretion of L-glutamate from osteoclasts through transcytosis.Ca2+-mediated ascorbate release from coronary artery endothelial cells.Activation and regulation of purinergic P2X receptor channelsTranscriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions.Pannexin 3 functions as an ER Ca(2+) channel, hemichannel, and gap junction to promote osteoblast differentiation.Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice.P2X7 on Mouse T Cells: One Channel, Many FunctionsThe P2X(7) receptor regulates proteoglycan expression in the corneal stromaDetection of multiple autoantibodies in patients with ankylosing spondylitis using nucleic acid programmable protein arrays.Expression, assembly and function of novel C-terminal truncated variants of the mouse P2X7 receptor: re-evaluation of P2X7 knockoutsSingle-nucleotide polymorphisms in the P2X7 receptor gene are associated with post-menopausal bone loss and vertebral fracturesP2X7R-Panx1 Complex Impairs Bone Mechanosignaling under High Glucose Levels Associated with Type-1 DiabetesModulating P2X7 Receptor Signaling during Rheumatoid Arthritis: New Therapeutic Approaches for BisphosphonatesMechanical vibration inhibits osteoclast formation by reducing DC-STAMP receptor expression in osteoclast precursor cells.Association between P2X7 Receptor Polymorphisms and Bone Status in Mice.Genetic Background Strongly Influences the Bone Phenotype of P2X7 Receptor Knockout Mice
P2860
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P2860
Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption
description
2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im Juli 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/07/01)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/07/01)
@nl
наукова стаття, опублікована в липні 2003
@uk
مقالة علمية (نشرت في يوليو 2003)
@ar
name
Deletion of the P2X7 nucleotid ...... bone formation and resorption
@ast
Deletion of the P2X7 nucleotid ...... bone formation and resorption
@en
Deletion of the P2X7 nucleotid ...... bone formation and resorption
@nl
type
label
Deletion of the P2X7 nucleotid ...... bone formation and resorption
@ast
Deletion of the P2X7 nucleotid ...... bone formation and resorption
@en
Deletion of the P2X7 nucleotid ...... bone formation and resorption
@nl
prefLabel
Deletion of the P2X7 nucleotid ...... bone formation and resorption
@ast
Deletion of the P2X7 nucleotid ...... bone formation and resorption
@en
Deletion of the P2X7 nucleotid ...... bone formation and resorption
@nl
P2093
P3181
P356
P1476
Deletion of the P2X7 nucleotid ...... bone formation and resorption
@en
P2093
A. Frederik Weidema
Christopher A. Gabel
D. Todd Crawford
David D. Thompson
Hua Zhu Ke
Laurent P. Audoly
Nattapon Panupinthu
Qing Zhang
P304
P3181
P356
10.1210/ME.2003-0021
P577
2003-07-01T00:00:00Z