Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice. - Wikidata - wikimedia - TriplyDB

Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice.

Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice.

http://www.wikidata.org/entity/Q35559060

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In vitro and in vivo approaches to study osteocyte biology Recent progress in osteocyte research The interaction of biological factors with mechanical signals in bone adaptation: recent developments Osteocytes: master orchestrators of bone Preosteocytes/osteocytes have the potential to dedifferentiate becoming a source of osteoblasts Physiological mechanisms and therapeutic potential of bone mechanosensing.The intraflagellar transport protein IFT80 is required for cilia formation and osteogenesis Osteocyte-specific deletion of Fgfr1 suppresses FGF23 Osteoblast-specific deletion of Pkd2 leads to low-turnover osteopenia and reduced bone marrow adiposity A mathematical model for mechanotransduction at the early steps of suture formation The primary cilium functions as a mechanical and calcium signaling nexus Primary cilia respond to fluid shear stress and mediate flow-induced calcium deposition in osteoblasts.Conditional mesenchymal disruption of pkd1 results in osteopenia and polycystic kidney disease.A new method to investigate how mechanical loading of osteocytes controls osteoblasts Function and regulation of primary cilia and intraflagellar transport proteins in the skeleton HIF-1α regulates bone formation after osteogenic mechanical loading.Polycystin-1 mediates mechanical strain-induced osteoblastic mechanoresponses via potentiation of intracellular calcium and Akt/β-catenin pathway Bone-remodeling transcript levels are independent of perching in end-of-lay white leghorn chickens Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading.Cell autonomous requirement of connexin 43 for osteocyte survival: consequences for endocortical resorption and periosteal bone formation.Genetic mouse models for bone studies--strengths and limitations Conditional Deletion of Fgfr1 in the Proximal and Distal Tubule Identifies Distinct Roles in Phosphate and Calcium Transport.Disruption of Kif3a in osteoblasts results in defective bone formation and osteopenia.Bone and skeletal muscle: Key players in mechanotransduction and potential overlapping mechanisms.DMP-1-mediated Ghr gene recombination compromises skeletal development and impairs skeletal response to intermittent PTH.Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation LRP5 and bone mass regulation: Where are we now?The osteocyte: an endocrine cell ... and more.Counter-regulatory paracrine actions of FGF-23 and 1,25(OH)2 D in macrophages.Role of Osteocyte-derived Insulin-Like Growth Factor I in Developmental Growth, Modeling, Remodeling, and Regeneration of the Bone.Mitochondrial superoxide in osteocytes perturbs canalicular networks in the setting of age-related osteoporosis.Emerging role of primary cilia as mechanosensors in osteocytes From bone abnormalities to mineral metabolism dysregulation in autosomal dominant polycystic kidney disease.Talking among ourselves: paracrine control of bone formation within the osteoblast lineage.Overcoming physical constraints in bone engineering: 'the importance of being vascularized'.Osteocyte Mechanobiology.Mechanosensor polycystin-1 potentiates differentiation of human osteoblastic cells by upregulating Runx2 expression via induction of JAK2/STAT3 signaling axis.The Role of Osteocytes in Age-Related Bone Loss.Functional Diversity of Ciliary Proteins in Bone Development and Disease.Downregulation of PKD1 by shRNA results in defective osteogenic differentiation via cAMP/PKA pathway in human MG-63 cells.

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P2860

Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice.

http://www.wikidata.org/entity/Q35559060

description

2011 nî lūn-bûn

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2011年の論文

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2011年论文

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name

Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice.

@ast

Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice.

@en

type

label

Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice.

@ast

Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice.

@en

prefLabel

Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice.

@ast

Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice.

@en

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Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice.

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Daniel Nicolella

http://www.w3.org/2001/XMLSchema#string

L Darryl Quarles

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Li Cao

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Lynda Bonewald

http://www.w3.org/2001/XMLSchema#string

Mark Dallas

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Mark Johnson

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Ni Qiu

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Zhousheng Xiao

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P2860

Strong homophilic interactions of the Ig-like domains of polycystin-1, the protein product of an autosomal dominant polycystic kidney disease gene, PKD1

Interaction between RGS7 and polycystin

Osteonal and hemi-osteonal remodeling: the spatial and temporal framework for signal traffic in adult human bone

The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment

Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin

Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation

Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene

Bone biomechanical properties in LRP5 mutant mice

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mechanosensation

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3219213

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