Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination
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Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stressRad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaksDNA damage response genes and the development of cancer metastasisMouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsisRTEL1 contributes to DNA replication and repair and telomere maintenance.BRIT1 regulates early DNA damage response, chromosomal integrity, and cancerRad21-cohesin haploinsufficiency impedes DNA repair and enhances gastrointestinal radiosensitivity in mice.Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma modelDimerization of the ATRIP protein through the coiled-coil motif and its implication to the maintenance of stalled replication forksMouse Rad9b is essential for embryonic development and promotes resistance to DNA damageNBS1 cooperates with homologous recombination to counteract chromosome breakage during replication.Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition.Mutator phenotype of Caenorhabditis elegans DNA damage checkpoint mutantsIncreased common fragile site expression, cell proliferation defects, and apoptosis following conditional inactivation of mouse Hus1 in primary cultured cells.Genome maintenance defects in cultured cells and mice following partial inactivation of the essential cell cycle checkpoint gene Hus1.The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates DNA repair enzyme TDG glycosylaseRegulation of Rad17 protein turnover unveils an impact of Rad17-APC cascade in breast carcinogenesis and treatment.Mammalian Rif1 contributes to replication stress survival and homology-directed repair.The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks.Hepatitis B virus X protein increases the Cdt1-to-geminin ratio inducing DNA re-replication and polyploidy.The 9-1-1 DNA clamp is required for immunoglobulin gene conversion.Functional differentiation of SWI/SNF remodelers in transcription and cell cycle control.Hydroxyurea responsiveness in β-thalassemic patients is determined by the stress response adaptation of erythroid progenitors and their differentiation propensity.Ubiquitin-specific peptidase 20 regulates Rad17 stability, checkpoint kinase 1 phosphorylation and DNA repair by homologous recombination.OsRAD17 Is Required for Meiotic Double-Strand Break Repair and Plays a Redundant Role With OsZIP4 in Synaptonemal Complex Assembly
P2860
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P2860
Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination
description
2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
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im September 2004 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2004/09/01)
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vědecký článek publikovaný v roce 2004
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wetenschappelijk artikel (gepubliceerd op 2004/09/01)
@nl
наукова стаття, опублікована у вересні 2004
@uk
مقالة علمية (نشرت في سبتمبر 2004)
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name
Mutation of the mouse Rad17 ge ...... damage-dependent recombination
@ast
Mutation of the mouse Rad17 ge ...... damage-dependent recombination
@en
Mutation of the mouse Rad17 ge ...... damage-dependent recombination
@nl
type
label
Mutation of the mouse Rad17 ge ...... damage-dependent recombination
@ast
Mutation of the mouse Rad17 ge ...... damage-dependent recombination
@en
Mutation of the mouse Rad17 ge ...... damage-dependent recombination
@nl
prefLabel
Mutation of the mouse Rad17 ge ...... damage-dependent recombination
@ast
Mutation of the mouse Rad17 ge ...... damage-dependent recombination
@en
Mutation of the mouse Rad17 ge ...... damage-dependent recombination
@nl
P2093
P2860
P356
P1433
P1476
Mutation of the mouse Rad17 ge ...... damage-dependent recombination
@en
P2093
Annelies de Klein
Berna Beverloo
Ellen van Drunen
Harm de Waard
Iris Jaspers
Jan H. Hoeijmakers
Jeroen Essers
Katsuhiro Hanada
Magda Budzowska
P2860
P304
P356
10.1038/SJ.EMBOJ.7600353
P407
P577
2004-09-01T00:00:00Z