Reduced c-Myb activity compromises HSCs and leads to a myeloproliferation with a novel stem cell basis
about
Conditional c-myb knockout in adult hematopoietic stem cells leads to loss of self-renewal due to impaired proliferation and accelerated differentiationc-Myb and GATA-1 alternate dominant roles during megakaryocyte differentiation.The chicken miR-150 targets the avian orthologue of the functional zebrafish MYB 3'UTR target site.p89c-Myb is not required for fetal or adult hematopoiesisComputational analysis of expression of human embryonic stem cell-associated signatures in tumors.Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms.c-Myb Binding Sites in Haematopoietic Chromatin LandscapesRegulation of the Flt3 Gene in Haematopoietic Stem and Early Progenitor Cells.Impaired adult myeloid progenitor CMP and GMP cell function in conditional c-myb-knockout miceMyb proteins: angels and demons in normal and transformed cells.Molecular determinants of pathogenesis and clinical phenotype in myeloproliferative neoplasms.B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development.Hematopoietic stem cell emergence in the conceptus and the role of Runx1.Transcriptional regulation of SPROUTY2 by MYB influences myeloid cell proliferation and stem cell properties by enhancing responsiveness to IL-3.Determining c-Myb protein levels can isolate functional hematopoietic stem cell subtypes.Distinct regulation of c-myb gene expression by HoxA9, Meis1 and Pbx proteins in normal hematopoietic progenitors and transformed myeloid cells.c-myb hyperactivity leads to myeloid and lymphoid malignancies in zebrafish.A population of innate myelolymphoblastoid effector cell expanded by inactivation of mTOR complex 1 in mice.A novel recurrent copy number loss region on 6q23.3 in MDS-related myeloid malignancy patients with stable survival conditions.
P2860
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P2860
Reduced c-Myb activity compromises HSCs and leads to a myeloproliferation with a novel stem cell basis
description
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2009 թվականի մայիսին հրատարակված գիտական հոդված
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artículu científicu espublizáu en 2009
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im Mai 2009 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2009/05/20)
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vědecký článek publikovaný v roce 2009
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wetenschappelijk artikel (gepubliceerd op 2009/05/20)
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наукова стаття, опублікована в травні 2009
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مقالة علمية (نشرت في 20-5-2009)
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name
Reduced c-Myb activity comprom ...... n with a novel stem cell basis
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Reduced c-Myb activity comprom ...... n with a novel stem cell basis
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Reduced c-Myb activity comprom ...... n with a novel stem cell basis
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type
label
Reduced c-Myb activity comprom ...... n with a novel stem cell basis
@ast
Reduced c-Myb activity comprom ...... n with a novel stem cell basis
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Reduced c-Myb activity comprom ...... n with a novel stem cell basis
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prefLabel
Reduced c-Myb activity comprom ...... n with a novel stem cell basis
@ast
Reduced c-Myb activity comprom ...... n with a novel stem cell basis
@en
Reduced c-Myb activity comprom ...... n with a novel stem cell basis
@nl
P2093
P2860
P921
P356
P1433
P1476
Reduced c-Myb activity comprom ...... n with a novel stem cell basis
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P2093
Alexandros Vegiopoulos
Ana Camelo
Jon Frampton
Mary Clarke
Oscar Berlanga
P2860
P304
P356
10.1038/EMBOJ.2009.97
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P577
2009-04-09T00:00:00Z