Multiple hematopoietic defects and delayed globin switching in Ikaros null mice
about
Cell cycle-specific function of Ikaros in human leukemiaEmbryonic stem cell differentiation: a chromatin perspectiveCurrent concepts in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemiaMi2β is required for γ-globin gene silencing: temporal assembly of a GATA-1-FOG-1-Mi2 repressor complex in β-YAC transgenic miceIkaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongationReduced c-Myb activity compromises HSCs and leads to a myeloproliferation with a novel stem cell basisPGC-1 coactivator activity is required for murine erythropoiesis.Characterization of the transcriptome profiles related to globin gene switching during in vitro erythroid maturation.Transcriptional control of erythropoiesis: emerging mechanisms and principles.Inhibitory effects of transcription factor Ikaros on the expression of liver cancer stem cell marker CD133 in hepatocellular carcinoma.Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells.Genetic programs regulating HSC specification, maintenance and expansion.The AT-rich DNA-binding protein SATB2 promotes expression and physical association of human (G)γ- and (A)γ-globin genes.Regulation of human fetal hemoglobin: new players, new complexities.Function of Ikaros as a tumor suppressor in B cell acute lymphoblastic leukemiaPomalidomide reverses γ-globin silencing through the transcriptional reprogramming of adult hematopoietic progenitorsRecurrent deletions of IKZF1 in pediatric acute myeloid leukemiaIkaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signalingTranscriptional mechanisms underlying hemoglobin synthesis.Early hematopoietic lineage restrictions directed by Ikaros.Advances in the understanding of haemoglobin switching.Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders.Ikaros and leukaemia.Direct protein interactions are responsible for Ikaros-GATA and Ikaros-Cdk9 cooperativeness in hematopoietic cellsRegulation of the mouse Treacher Collins syndrome homolog (Tcof1) promoter through differential repression of constitutive expression.Human Ikaros function in activated T cells is regulated by coordinated expression of its largest isoforms.Hydroxyurea responsiveness in β-thalassemic patients is determined by the stress response adaptation of erythroid progenitors and their differentiation propensity.Ikaros is expressed in human extravillous trophoblasts and involved in their migration and invasion.Embryonic lethality, decreased erythropoiesis, and defective octamer-dependent promoter activation in Oct-1-deficient mice.Normal hematologic parameters and fetal hemoglobin silencing with heterozygous IKZF1 mutationsIkaros in B cell development and function.Understanding globin regulation in beta-thalassemia: it's as simple as alpha, beta, gamma, deltaA dominant-negative isoform of IKAROS expands primitive normal human hematopoietic cells.Ikaros and GATA-1 combinatorial effect is required for silencing of human gamma-globin genes.A mechanism for Ikaros regulation of human globin gene switching.Genome-wide association study identifies new susceptibility loci for cutaneous lupus erythematosus.The many faces of IKZF1 in B-cell precursor acute lymphoblastic leukemia.Deletions of the transcription factor Ikaros in myeloproliferative neoplasms.
P2860
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P2860
Multiple hematopoietic defects and delayed globin switching in Ikaros null mice
description
2002 nî lūn-bûn
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2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունվարին հրատարակված գիտական հոդված
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2002年の論文
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2002年学术文章
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2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
name
Multiple hematopoietic defects and delayed globin switching in Ikaros null mice
@ast
Multiple hematopoietic defects and delayed globin switching in Ikaros null mice
@en
Multiple hematopoietic defects and delayed globin switching in Ikaros null mice
@nl
type
label
Multiple hematopoietic defects and delayed globin switching in Ikaros null mice
@ast
Multiple hematopoietic defects and delayed globin switching in Ikaros null mice
@en
Multiple hematopoietic defects and delayed globin switching in Ikaros null mice
@nl
prefLabel
Multiple hematopoietic defects and delayed globin switching in Ikaros null mice
@ast
Multiple hematopoietic defects and delayed globin switching in Ikaros null mice
@en
Multiple hematopoietic defects and delayed globin switching in Ikaros null mice
@nl
P2093
P2860
P356
P1476
Multiple hematopoietic defects and delayed globin switching in Ikaros null mice
@en
P2093
Arthur Bank
David O'Neill
Kathryn DeAngelis
Rocio A Lopez
Stuti Schoetz
P2860
P304
P356
10.1073/PNAS.022412699
P407
P577
2002-01-01T00:00:00Z