New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway
about
Function, regulation and pathological roles of the Gab/DOS docking proteinsUse of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasisInteraction of the tyrosine phosphatase SHP-2 with Gab2 regulates Rho-dependent activation of the c-fos serum response element by interleukin-2Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cellsPhosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking proteinJFC1 is transcriptionally activated by nuclear factor-kappaB and up-regulated by tumour necrosis factor alpha in prostate carcinoma cellsPKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2.Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation.8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathwaysStimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteinsBiological activity of the thyroid TRK-T3 oncogene requires signalling through ShcStructure and function of Gab2 and its role in cancer (Review)MET: a critical player in tumorigenesis and therapeutic targetGC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2A yeast two-hybrid study of human p97/Gab2 interactions with its SH2 domain-containing binding partnersThe role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptorsRole of Gab proteins in phosphatidylinositol 3-kinase activation by thrombopoietin (Tpo)Interaction domains: from simple binding events to complex cellular behaviorShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation.Differential regulation of Shc adaptor proteins in skeletal muscle, spinal cord and forebrain of aged rats with sensorimotor impairmentThe PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3Role of Shc in T-cell development and function.Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells.Evidence of STAT5-dependent and -independent routes to CD8 memory formation and a preferential role for IL-7 over IL-15 in STAT5 activationDisruption of the Shc/Grb2 complex during abelson virus transformation affects proliferation, but not apoptosis.IL-15: a central regulator of celiac disease immunopathology.Signal transduction by different forms of the γδ T cell-specific pattern recognition receptor WC1.Activity of any class IA PI3K isoform can sustain cell proliferation and survival.Scaffolding protein Gab2 mediates differentiation signaling downstream of Fms receptor tyrosine kinaseRegulation of Id gene expression by type I insulin-like growth factor: roles of Stat3 and the tyrosine 950 residue of the receptor.Progesterone reverses the mesenchymal phenotypes of basal phenotype breast cancer cells via a membrane progesterone receptor mediated pathwayp66ShcA promotes breast cancer plasticity by inducing an epithelial-to-mesenchymal transition.A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells.Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survivalHomeostatic control of lymphocyte survival: potential origins and implications.Lipid phosphatases in the regulation of T cell activation: living up to their PTEN-tial.An Interaction Library for the FcεRI Signaling NetworkEssential roles of Gab1 tyrosine phosphorylation in growth factor-mediated signaling and angiogenesisCytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand.The interleukin (IL)-2 family cytokines: survival and proliferation signaling pathways in T lymphocytes.
P2860
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P2860
New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway
description
2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2000
@ast
im Oktober 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/10/01)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/10/01)
@nl
наукова стаття, опублікована в жовтні 2000
@uk
مقالة علمية (نشرت في أكتوبر 2000)
@ar
name
New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway
@ast
New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway
@en
New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway
@nl
type
label
New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway
@ast
New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway
@en
New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway
@nl
prefLabel
New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway
@ast
New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway
@en
New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway
@nl
P2093
P2860
P1476
New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway
@en
P2093
P2860
P304
P356
10.1128/MCB.20.19.7109-7120.2000
P407
P577
2000-10-01T00:00:00Z