A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells.
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Grb2-associated binding (Gab) proteins in hematopoietic and immune cell biologyRASopathies: unraveling mechanisms with animal modelsGAB2--a scaffolding protein in cancerOrder and disorder in large multi-site docking proteins of the Gab family--implications for signalling complex formation and inhibitor design strategiesThe role of atypical protein kinase C in CSF-1-dependent Erk activation and proliferation in myeloid progenitors and macrophagesActivating mutations in protein tyrosine phosphatase Ptpn11 (Shp2) enhance reactive oxygen species production that contributes to myeloproliferative disorderKit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool.Protein Tyrosine Phosphatase SHP-2 (PTPN11) in Hematopoiesis and Leukemogenesis.Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells.Protein tyrosine phosphatase-σ regulates hematopoietic stem cell-repopulating capacityGab2 promotes colony-stimulating factor 1-regulated macrophage expansion via alternate effectors at different stages of development.Molecular targets for the treatment of juvenile myelomonocytic leukemia.Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition.Shp2 function in hematopoietic stem cell biology and leukemogenesis.Peripheral blood cells from children with RASopathies show enhanced spontaneous colonies growth in vitro and hyperactive RAS signaling.Functions of Shp2 in cancer.SH2 domain-containing phosphatase 2 is a critical regulator of connective tissue mast cell survival and homeostasis in miceRole of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT.Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignanciesA comprehensive analysis of GATA-1-regulated miRNAs reveals miR-23a to be a positive modulator of erythropoiesis.Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiationConditional Knockout of Src Homology 2 Domain-containing Protein Tyrosine Phosphatase-2 in Myeloid Cells Attenuates Renal Fibrosis after Unilateral Ureter Obstruction.Induction of a tumor-associated activating mutation in protein tyrosine phosphatase Ptpn11 (Shp2) enhances mitochondrial metabolism, leading to oxidative stress and senescence.Lnk adaptor suppresses radiation resistance and radiation-induced B-cell malignancies by inhibiting IL-11 signaling.Dual faces of SH2-containing protein-tyrosine phosphatase Shp2/PTPN11 in tumorigenesis.Modeling RASopathies with Genetically Modified Mouse Models.LEOPARD-type SHP2 mutant Gln510Glu attenuates cardiomyocyte differentiation and promotes cardiac hypertrophy via dysregulation of Akt/GSK-3β/β-catenin signaling.Gab adapter proteins as therapeutic targets for hematologic disease.Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors.
P2860
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P2860
A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
A germline gain-of-function mu ...... n of hematopoietic stem cells.
@ast
A germline gain-of-function mu ...... n of hematopoietic stem cells.
@en
A germline gain-of-function mutation in Ptpn11
@nl
type
label
A germline gain-of-function mu ...... n of hematopoietic stem cells.
@ast
A germline gain-of-function mu ...... n of hematopoietic stem cells.
@en
A germline gain-of-function mutation in Ptpn11
@nl
prefLabel
A germline gain-of-function mu ...... n of hematopoietic stem cells.
@ast
A germline gain-of-function mu ...... n of hematopoietic stem cells.
@en
A germline gain-of-function mutation in Ptpn11
@nl
P2093
P2860
P1433
P1476
A germline gain-of-function mu ...... n of hematopoietic stem cells.
@en
P2093
Benjamin G Neel
Cheng-Kui Qu
Gordon Chan
Kevin D Bunting
Siying Wang
Toshiyuki Araki
Wen-Mei Yu
P2860
P304
P356
10.1182/BLOOD-2010-01-265652
P407
P577
2010-07-22T00:00:00Z