ZNF198-FGFR1 transforms Ba/F3 cells to growth factor independence and results in high level tyrosine phosphorylation of STATS 1 and 5
about
PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder.The oncogenic fusion protein-tyrosine kinase ZNF198/fibroblast growth factor receptor-1 has signaling function comparable with interleukin-6 cytokine receptorsExpression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation.Phosphorylation of the SSBP2 and ABL proteins by the ZNF198-FGFR1 fusion kinase seen in atypical myeloproliferative disorders as revealed by phosphopeptide-specific MS.STAT5 acts as a repressor to regulate early embryonic erythropoiesis.14-3-3 Integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1-transformed hematopoietic cells.Molecular classification and pathogenesis of eosinophilic disorders: 2005 update.Ponatinib as targeted therapy for FGFR1 fusions associated with the 8p11 myeloproliferative syndromeStat5 as a diagnostic marker for leukemia.The 8p11 myeloproliferative syndrome: review of literature and an illustrative case report.Targeting mutant fibroblast growth factor receptors in cancer.Pediatric 8p11 eosinophilic myeloproliferative syndrome (EMS): A case report and review of the literature.Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements.Identification of protein tyrosine kinases with oncogenic potential using a retroviral insertion mutagenesis screen.Fibroblast growth factor receptor-induced phosphorylation of STAT1 at the Golgi apparatus without translocation to the nucleus.Targeting FGFR3 in multiple myeloma: inhibition of t(4;14)-positive cells by SU5402 and PD173074.Critical role of STAT5 activation in transformation mediated by ZNF198-FGFR1.Identification of four new translocations involving FGFR1 in myeloid disorders.Signaling by cytosolic FGFR1 fusion mutantsMyeloid/lymphoid neoplasms with FGFR1 rearrangement.Phosphorylation of STAT5 by cytosolic FGFR1 fusions
P2860
Q27824821-95839796-1C08-4620-AD17-189B39645CD3Q28210567-19824B51-238D-420D-96FB-816ADD078BD5Q34245259-A989BB1D-BF58-4618-ABEF-3305DF0D9375Q34378275-FDAB5DEF-285C-4A60-B4CB-4F7CF5A634BBQ35849020-96E2D7DC-969C-47D6-B8CA-66FA9A68B204Q35850692-E3F4559D-C242-4208-8158-01EA51D090ECQ36182741-4F82A417-4285-42D8-9CBF-6B980F0C5017Q36498390-03FDC9C5-AA8F-45FA-9C0F-14AAC8268B8EQ37035281-E7CC66D6-45FD-40D4-9765-741AE159D05CQ37267228-F77EC217-8C40-4A1B-95EB-EB4EF19DC0DBQ37849013-2AB4DC4F-8BC1-4FFC-BBB2-3075817195C0Q38997342-90271BBA-904A-4954-8B34-AB76B57F440BQ39300448-5D15841B-9B76-4D2B-89F9-75239B63C8C9Q39793134-EB357E6D-FC2D-4012-BE0A-F7A93F4013E2Q40169063-2662E3B2-76ED-456C-BE24-A8B444EA6018Q40577049-E5E730FF-EB1D-4524-A4A5-F27A1D2A49DDQ40609712-E5B61573-3FDC-4F17-A70C-8BDEB07852ECQ43732967-9D96AAE0-F072-4D05-8708-CB326D4F646EQ45314363-603D7C57-4D16-4673-8336-FD11F128E704Q47849783-664C87BC-96BA-420B-8497-A21D2BA8087AQ50288682-D5E59075-B336-4F71-BF9F-4C3EDCE7B97F
P2860
ZNF198-FGFR1 transforms Ba/F3 cells to growth factor independence and results in high level tyrosine phosphorylation of STATS 1 and 5
description
1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1999
@ast
scientific journal article
@en
vedecký článok (publikovaný 1999/10/01)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/10/01)
@nl
wissenschaftlicher Artikel
@de
наукова стаття, опублікована в жовтні 1999
@uk
مقالة علمية (نشرت في أكتوبر 1999)
@ar
name
ZNF198-FGFR1 transforms Ba/F3 ...... osphorylation of STATS 1 and 5
@ast
ZNF198-FGFR1 transforms Ba/F3 ...... osphorylation of STATS 1 and 5
@en
ZNF198-FGFR1 transforms Ba/F3 ...... osphorylation of STATS 1 and 5
@nl
type
label
ZNF198-FGFR1 transforms Ba/F3 ...... osphorylation of STATS 1 and 5
@ast
ZNF198-FGFR1 transforms Ba/F3 ...... osphorylation of STATS 1 and 5
@en
ZNF198-FGFR1 transforms Ba/F3 ...... osphorylation of STATS 1 and 5
@nl
prefLabel
ZNF198-FGFR1 transforms Ba/F3 ...... osphorylation of STATS 1 and 5
@ast
ZNF198-FGFR1 transforms Ba/F3 ...... osphorylation of STATS 1 and 5
@en
ZNF198-FGFR1 transforms Ba/F3 ...... osphorylation of STATS 1 and 5
@nl
P2093
P2860
P356
P1433
P1476
ZNF198-FGFR1 transforms Ba/F3 ...... osphorylation of STATS 1 and 5
@en
P2093
A. Demiroglu
D. Smedley
J. Shipley
M. Abdul-Rauf
N. C. Cross
P2860
P304
P356
10.1038/SJ.NEO.7900035
P577
1999-10-01T00:00:00Z