ZNF198-FGFR1 transforms Ba/F3 cells to growth factor independence and results in high level tyrosine phosphorylation of STATS 1 and 5 - Wikidata - wikimedia - TriplyDB

ZNF198-FGFR1 transforms Ba/F3 cells to growth factor independence and results in high level tyrosine phosphorylation of STATS 1 and 5

ZNF198-FGFR1 transforms Ba/F3 cells to growth factor independence and results in high level tyrosine phosphorylation of STATS 1 and 5

http://www.wikidata.org/entity/Q28609080

about

PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder.The oncogenic fusion protein-tyrosine kinase ZNF198/fibroblast growth factor receptor-1 has signaling function comparable with interleukin-6 cytokine receptors Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation.Phosphorylation of the SSBP2 and ABL proteins by the ZNF198-FGFR1 fusion kinase seen in atypical myeloproliferative disorders as revealed by phosphopeptide-specific MS.STAT5 acts as a repressor to regulate early embryonic erythropoiesis.14-3-3 Integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1-transformed hematopoietic cells.Molecular classification and pathogenesis of eosinophilic disorders: 2005 update.Ponatinib as targeted therapy for FGFR1 fusions associated with the 8p11 myeloproliferative syndrome Stat5 as a diagnostic marker for leukemia.The 8p11 myeloproliferative syndrome: review of literature and an illustrative case report.Targeting mutant fibroblast growth factor receptors in cancer.Pediatric 8p11 eosinophilic myeloproliferative syndrome (EMS): A case report and review of the literature.Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements.Identification of protein tyrosine kinases with oncogenic potential using a retroviral insertion mutagenesis screen.Fibroblast growth factor receptor-induced phosphorylation of STAT1 at the Golgi apparatus without translocation to the nucleus.Targeting FGFR3 in multiple myeloma: inhibition of t(4;14)-positive cells by SU5402 and PD173074.Critical role of STAT5 activation in transformation mediated by ZNF198-FGFR1.Identification of four new translocations involving FGFR1 in myeloid disorders.Signaling by cytosolic FGFR1 fusion mutants Myeloid/lymphoid neoplasms with FGFR1 rearrangement.Phosphorylation of STAT5 by cytosolic FGFR1 fusions

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ZNF198-FGFR1 transforms Ba/F3 cells to growth factor independence and results in high level tyrosine phosphorylation of STATS 1 and 5

http://www.wikidata.org/entity/Q28609080

description

1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

1999 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 1999

@ast

scientific journal article

@en

vedecký článok (publikovaný 1999/10/01)

@sk

vědecký článek publikovaný v roce 1999

@cs

wetenschappelijk artikel (gepubliceerd op 1999/10/01)

@nl

wissenschaftlicher Artikel

@de

наукова стаття, опублікована в жовтні 1999

@uk

مقالة علمية (نشرت في أكتوبر 1999)

@ar

name

ZNF198-FGFR1 transforms Ba/F3 ...... osphorylation of STATS 1 and 5

@ast

ZNF198-FGFR1 transforms Ba/F3 ...... osphorylation of STATS 1 and 5

@en

ZNF198-FGFR1 transforms Ba/F3 ...... osphorylation of STATS 1 and 5

@nl

type

label

ZNF198-FGFR1 transforms Ba/F3 ...... osphorylation of STATS 1 and 5

@ast

ZNF198-FGFR1 transforms Ba/F3 ...... osphorylation of STATS 1 and 5

@en

ZNF198-FGFR1 transforms Ba/F3 ...... osphorylation of STATS 1 and 5

@nl

prefLabel

ZNF198-FGFR1 transforms Ba/F3 ...... osphorylation of STATS 1 and 5

@ast

ZNF198-FGFR1 transforms Ba/F3 ...... osphorylation of STATS 1 and 5

@en

ZNF198-FGFR1 transforms Ba/F3 ...... osphorylation of STATS 1 and 5

@nl

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ZNF198-FGFR1 transforms Ba/F3 ...... osphorylation of STATS 1 and 5

@en

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A. Demiroglu

http://www.w3.org/2001/XMLSchema#string

C. Cooper

http://www.w3.org/2001/XMLSchema#string

C. Heath

http://www.w3.org/2001/XMLSchema#string

D. Smedley

http://www.w3.org/2001/XMLSchema#string

J. Shipley

http://www.w3.org/2001/XMLSchema#string

M. Abdul-Rauf

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N. C. Cross

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P2860

Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction

A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1

Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13)

Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription

A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia

FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome

The t(8;13)(p11;q11-12) rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP

p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl

P304

349–355

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scholarly article

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10.1038/SJ.NEO.7900035

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P433

4

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1

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1999-10-01T00:00:00Z

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P5875

12384174

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P698

10935490

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P921

phosphorylation

P932

1508104

http://www.w3.org/2001/XMLSchema#string