Phosphorylation of the cystic fibrosis transmembrane conductance regulator
about
A systematic comparative and structural analysis of protein phosphorylation sites based on the mtcPTM databaseCalmodulin-kinases: modulators of neuronal development and plasticityHuman calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinaseThe ABC protein turned chloride channel whose failure causes cystic fibrosisCFTR gating I: Characterization of the ATP-dependent gating of a phosphorylation-independent CFTR channel (DeltaR-CFTR).The primary folding defect and rescue of ΔF508 CFTR emerge during translation of the mutant domainSphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) ActivityEnteric bacterial toxins: mechanisms of action and linkage to intestinal secretion.Activation of host cell protein kinase C by enteropathogenic Escherichia coli.Cystic fibrosis: exploiting its genetic basis in the hunt for new therapiesThe cystic fibrosis transmembrane conductance regulator (CFTR) is expressed in maturation stage ameloblasts, odontoblasts and bone cellsSerum- and glucocorticoid-induced protein kinase 1 (SGK1) increases the cystic fibrosis transmembrane conductance regulator (CFTR) in airway epithelial cells by phosphorylating Shank2E protein.Bacterial Sphingomyelinase is a State-Dependent Inhibitor of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR)CFTR-adenylyl cyclase I association responsible for UTP activation of CFTR in well-differentiated primary human bronchial cell cultures.The tyrosine kinase p60c-src regulates the fast gate of the cystic fibrosis transmembrane conductance regulator chloride channelRegulation of recombinant cardiac cystic fibrosis transmembrane conductance regulator chloride channels by protein kinase C.Conformation, independent of charge, in the R domain affects cystic fibrosis transmembrane conductance regulator channel openingscGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action.Mutual enhancement of virulence by enterotoxigenic and enteropathogenic Escherichia coliTransfer of a constitutive viral promoter-cystic fibrosis transmembrane conductance regulator cDNA to human epithelial cells conveys resistance to down-regulation of cAMP-regulated Cl- secretion in the presence of inflammatory stimuli.Stimulatory and inhibitory protein kinase C consensus sequences regulate the cystic fibrosis transmembrane conductance regulatorMolecular basis of protein kinase C-induced activation of ATP-sensitive potassium channels.Regulation of the gating of cystic fibrosis transmembrane conductance regulator C1 channels by phosphorylation and ATP hydrolysisCFTR mediates noradrenaline-induced ATP efflux from DRG neurons.A requirement of hydrophobic and basic amino acid residues for substrate recognition by Ca2+/calmodulin-dependent protein kinase Ia.Activation of protein kinase A acutely inhibits and phosphorylates Na/H exchanger NHE-3.Phosphatase inhibitors activate normal and defective CFTR chloride channelsMembrane targeting of cGMP-dependent protein kinase is required for cystic fibrosis transmembrane conductance regulator Cl- channel activation.Site-directed mutagenesis of amino acid residues of protein phosphatase 1 involved in catalysis and inhibitor binding.Identification of protein kinase A phosphorylation sites on NBD1 and R domains of CFTR using electrospray mass spectrometry with selective phosphate ion monitoring.Evidence for phosphorylation of serine 753 in CFTR using a novel metal-ion affinity resin and matrix-assisted laser desorption mass spectrometry.Functionally distinct phospho-forms underlie incremental activation of protein kinase-regulated Cl- conductance in mammalian heart.On the mechanism of MgATP-dependent gating of CFTR Cl- channelsPreferential phosphorylation of R-domain Serine 768 dampens activation of CFTR channels by PKA.Severed molecules functionally define the boundaries of the cystic fibrosis transmembrane conductance regulator's NH(2)-terminal nucleotide binding domain.Polarized signaling via purinoceptors in normal and cystic fibrosis airway epithelia.PKC-mediated stimulation of amphibian CFTR depends on a single phosphorylation consensus site. insertion of this site confers PKC sensitivity to human CFTR.Severed channels probe regulation of gating of cystic fibrosis transmembrane conductance regulator by its cytoplasmic domainsDistinct Mg(2+)-dependent steps rate limit opening and closing of a single CFTR Cl(-) channel.Prolonged nonhydrolytic interaction of nucleotide with CFTR's NH2-terminal nucleotide binding domain and its role in channel gating.
P2860
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P2860
Phosphorylation of the cystic fibrosis transmembrane conductance regulator
description
1992 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի հունիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1992
@ast
im Juni 1992 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1992/06/25)
@sk
vědecký článek publikovaný v roce 1992
@cs
wetenschappelijk artikel (gepubliceerd op 1992/06/25)
@nl
наукова стаття, опублікована в червні 1992
@uk
name
Phosphorylation of the cystic fibrosis transmembrane conductance regulator
@ast
Phosphorylation of the cystic fibrosis transmembrane conductance regulator
@en
Phosphorylation of the cystic fibrosis transmembrane conductance regulator
@nl
type
label
Phosphorylation of the cystic fibrosis transmembrane conductance regulator
@ast
Phosphorylation of the cystic fibrosis transmembrane conductance regulator
@en
Phosphorylation of the cystic fibrosis transmembrane conductance regulator
@nl
prefLabel
Phosphorylation of the cystic fibrosis transmembrane conductance regulator
@ast
Phosphorylation of the cystic fibrosis transmembrane conductance regulator
@en
Phosphorylation of the cystic fibrosis transmembrane conductance regulator
@nl
P2093
P921
P1476
Phosphorylation of the cystic fibrosis transmembrane conductance regulator
@en
P2093
A. C. Nairn
G. Bertuzzi
J. A. Cohn
M. R. Picciotto
P304
12742–12752
P407
P577
1992-06-25T00:00:00Z