Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops
about
Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteinsA Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulationA novel role of Sprouty 2 in regulating cellular apoptosisSprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulationTyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its functionStructural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substratesSpred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signalingExpression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomasProtein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligasesAdditional Serine/Threonine Phosphorylation Reduces Binding Affinity but Preserves Interface Topography of Substrate Proteins to the c-Cbl TKB DomainA functional interaction between sprouty proteins and caveolin-1Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasiaSuppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases.Regulation of sprouty stability by Mnk1-dependent phosphorylation.The VASP-Spred-Sprouty domain puzzle.How Genetics Has Helped Piece Together the MAPK Signaling Pathway.HECT domain-containing E3 ubiquitin ligase Nedd4 interacts with and ubiquitinates Sprouty2.Tyrosine phosphorylation of Sprouty proteins regulates their ability to inhibit growth factor signaling: a dual feedback loopEstablishment of extracellular signal-regulated kinase 1/2 bistability and sustained activation through Sprouty 2 and its relevance for epithelial function.Sprouty2 and Spred1-2 proteins inhibit the activation of the ERK pathway elicited by cyclopentenone prostanoidsThe developing story of Sprouty and cancer.Sprouty proteins inhibit receptor-mediated activation of phosphatidylinositol-specific phospholipase C.G Protein-regulated inducer of neurite outgrowth (GRIN) modulates Sprouty protein repression of mitogen-activated protein kinase (MAPK) activation by growth factor stimulation.Sprouty4 is an endogenous negative modulator of TrkA signaling and neuronal differentiation induced by NGFOverexpression of sprouty 2 inhibits HGF/SF-mediated cell growth, invasion, migration, and cytokinesis.Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells.Opposite feedbacks in the Hippo pathway for growth control and neural fate.ErbB2 stabilizes epidermal growth factor receptor (EGFR) expression via Erk and Sprouty2 in extracellular matrix-detached cellsTesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.Endocytosis and intracellular trafficking of ErbBs.Negative Regulation of Receptor Tyrosine Kinase (RTK) Signaling: A Developing FieldMitogen-activated protein kinase signalling and ERK1/2 bistability in asthma.Identification of a new Sprouty protein responsible for the inhibition of the Bombyx mori nucleopolyhedrovirus reproductionRegulation of cellular levels of Sprouty2 protein by prolyl hydroxylase domain and von Hippel-Lindau proteinsIntersectin 1 enhances Cbl ubiquitylation of epidermal growth factor receptor through regulation of Sprouty2-Cbl interactionFibrinogen inhibits neurite outgrowth via beta 3 integrin-mediated phosphorylation of the EGF receptorE3 ubiquitin ligases as regulators of membrane protein trafficking and degradation.c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses.EGF and amphiregulin differentially regulate Cbl recruitment to endosomes and EGF receptor fate.ERK MAP kinase in G cell cycle progression and cancer.
P2860
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P2860
Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops
description
2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im Februar 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/02/18)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/02/18)
@nl
наукова стаття, опублікована в лютому 2003
@uk
مقالة علمية (نشرت في 18-2-2003)
@ar
name
Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops
@ast
Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops
@en
Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops
@nl
type
label
Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops
@ast
Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops
@en
Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops
@nl
prefLabel
Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops
@ast
Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops
@en
Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops
@nl
P2093
P3181
P1433
P1476
Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops
@en
P2093
Chanan Rubin
Helena Medvedovsky
Vladi Litvak
Yaara Zwang
Yosef Yarden
P304
P3181
P356
10.1016/S0960-9822(03)00053-8
P407
P577
2003-02-18T00:00:00Z