Increased calvaria cell differentiation and bone matrix formation induced by fibroblast growth factor receptor 2 mutations in Apert syndrome
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A Genetic-Pathophysiological Framework for CraniosynostosisFibroblast growth factor signaling in skeletal development and diseaseEarly onset of craniosynostosis in an Apert mouse model reveals critical features of this pathologyConcerted action of Msx1 and Msx2 in regulating cranial neural crest cell differentiation during frontal bone developmentSox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiationActivation of p38 MAPK pathway in the skull abnormalities of Apert syndrome Fgfr2(+P253R) mice.Therapeutic effect of nanogel-based delivery of soluble FGFR2 with S252W mutation on craniosynostosis.Differential expression of extracellular matrix-mediated pathways in single-suture craniosynostosisCharacterization of distinct classes of differential gene expression in osteoblast cultures from non-syndromic craniosynostosis boneMechanisms balancing skeletal matrix synthesis and degradation.Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formationInvestigation of FGFR2-IIIC signaling via FGF-2 ligand for advancing GCT stromal cell differentiation.Inhibited Wnt signaling causes age-dependent abnormalities in the bone matrix mineralization in the Apert syndrome FGFR2(S252W/+) miceIn vivo modulation of FGF biological activity alters cranial suture fateDecreased proliferation and altered differentiation in osteoblasts from genetically and clinically distinct craniosynostotic disorders.Loss of fibroblast growth factor receptor 2 ligand-binding specificity in Apert syndrome.Apert p.Ser252Trp mutation in FGFR2 alters osteogenic potential and gene expression of cranial periosteal cells.Increased bone formation and decreased osteocalcin expression induced by reduced Twist dosage in Saethre-Chotzen syndrome.Signaling by fibroblast growth factors (FGF) and fibroblast growth factor receptor 2 (FGFR2)-activating mutations blocks mineralization and induces apoptosis in osteoblasts.Activation of the IGF1 pathway mediates changes in cellular contractility and motility in single-suture craniosynostosis.Further analysis of the Crouzon mouse: effects of the FGFR2(C342Y) mutation are cranial bone-dependentTwist1 homodimers enhance FGF responsiveness of the cranial sutures and promote suture closureE3 ubiquitin ligase-mediated regulation of bone formation and tumorigenesis.The molecular and cellular basis of Apert syndrome.A TWIST in the fate of human osteoblasts identifies signaling molecules involved in skull development.Fibroblast growth factor signaling uses multiple mechanisms to inhibit Wnt-induced transcription in osteoblasts.Scalp fibroblasts have a shared expression profile in monogenic craniosynostosis.Increased osteoblast apoptosis in apert craniosynostosis: role of protein kinase C and interleukin-1.Craniosynostosis-associated Fgfr2(C342Y) mutant bone marrow stromal cells exhibit cell autonomous abnormalities in osteoblast differentiation and bone formation.FGFR2 mutation confers a less drastic gain of function in mesenchymal stem cells than in fibroblasts.BMP9 induces osteogenesis and adipogenesis in the immortalized human cranial suture progenitors from the patent sutures of craniosynostosis patients.Fibroblast Growth Factor Receptor 2 (FGFR2) Mutation Related Syndromic Craniosynostosis.FGFR2b mutants bind an expanded range of ligandsFGFR2c mutants bind an expanded range of ligandsPostnatal brain and skull growth in an Apert syndrome mouse model.
P2860
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P2860
Increased calvaria cell differentiation and bone matrix formation induced by fibroblast growth factor receptor 2 mutations in Apert syndrome
description
1998 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1998
@ast
im März 1998 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1998/03/15)
@sk
vědecký článek publikovaný v roce 1998
@cs
wetenschappelijk artikel (gepubliceerd op 1998/03/15)
@nl
наукова стаття, опублікована в березні 1998
@uk
مقالة علمية (نشرت في 15-3-1998)
@ar
name
Increased calvaria cell differ ...... 2 mutations in Apert syndrome
@ast
Increased calvaria cell differ ...... 2 mutations in Apert syndrome
@en
Increased calvaria cell differ ...... 2 mutations in Apert syndrome
@nl
type
label
Increased calvaria cell differ ...... 2 mutations in Apert syndrome
@ast
Increased calvaria cell differ ...... 2 mutations in Apert syndrome
@en
Increased calvaria cell differ ...... 2 mutations in Apert syndrome
@nl
prefLabel
Increased calvaria cell differ ...... 2 mutations in Apert syndrome
@ast
Increased calvaria cell differ ...... 2 mutations in Apert syndrome
@en
Increased calvaria cell differ ...... 2 mutations in Apert syndrome
@nl
P2093
P2860
P1476
Increased calvaria cell differ ...... 2 mutations in Apert syndrome
@en
P2093
A. Munnich
E. Lajeunie
J. Lemonnier
N. de Parseval
P. J. Marie
P2860
P304
P407
P577
1998-03-15T00:00:00Z