The metabolic activation of abacavir by human liver cytosol and expressed human alcohol dehydrogenase isozymes
about
Abacavir induces loading of novel self-peptides into HLA-B*57: 01: an autoimmune model for HLA-associated drug hypersensitivity.Genetic factors in the predisposition to drug-induced hypersensitivity reactionsHypersensitivity reactions to HIV therapy.Human carbonyl reduction pathways and a strategy for their study in vitro.HIV-Antiretroviral Therapy Induced Liver, Gastrointestinal, and Pancreatic Injury.Use of antineoplastic agents in patients with cancer who have HIV/AIDS.Targeted therapies to treat non-AIDS-defining cancers in patients with HIV on HAART therapy: treatment considerations and research outlook.Drug bioactivation, covalent binding to target proteins and toxicity relevance.Aldehyde sources, metabolism, molecular toxicity mechanisms, and possible effects on human health.N-terminal valine adduct from the anti-HIV drug abacavir in rat haemoglobin as evidence for abacavir metabolism to a reactive aldehyde in vivo.Role of bioactivation in drug-induced hypersensitivity reactions.Mechanisms of drug-induced delayed-type hypersensitivity reactions in the skinInvolvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics.Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant.Successful translation of pharmacogenetics into the clinic: the abacavir example.HLA-B*5701 screening prior to abacavir prescription: clinical and laboratory aspects.Central role of mitochondria in drug-induced liver injury.The generation, detection, and effects of reactive drug metabolites.Hepatic metabolism: a key component of herbal drugs research.Are drug metabolites able to cause T-cell-mediated hypersensitivity reactions?Detecting reactive drug metabolites for reducing the potential for drug toxicity.The role of carbonyl reductase 1 in drug discovery and development.Non-cytochrome P450-mediated bioactivation and its toxicological relevance.Metabolism of F18, a Derivative of Calanolide A, in Human Liver Microsomes and Cytosol.Drug hypersensitivity reactions in patients with HIV disease.Avidity determines T-cell reactivity in abacavir hypersensitivity.Can fomepizole be substituted by abacavir in the treatment of methanol poisoning?Pharmacokinetics, disposition and lipid-modulating activity of 5-{2-[4-(3,4-difluorophenoxy)-phenyl]-ethylsulfamoyl}-2-methyl-benzoic acid, a potent and subtype-selective peroxisome proliferator-activated receptor alpha agonist in preclinical specieCytochrome P450 and Non-Cytochrome P450 Oxidative Metabolism: Contributions to the Pharmacokinetics, Safety, and Efficacy of Xenobiotics.abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+Metabolism and Bioactivation of Fluorochloridone, a Novel Selective Herbicide, in Vivo and in Vitro.Stereoselective hydroxylation by CYP2C19 and oxidation by ADH4 in the in vitro metabolism of tivantinib.
P2860
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P2860
The metabolic activation of abacavir by human liver cytosol and expressed human alcohol dehydrogenase isozymes
description
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
@ast
im November 2002 veröffentlicher wissenschaftlicher Artikel
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scientific journal article
@en
vedecký článok (publikovaný 2002/11/10)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/11/10)
@nl
наукова стаття, опублікована в листопаді 2002
@uk
مقالة علمية (نشرت في 10-11-2002)
@ar
name
The metabolic activation of ab ...... alcohol dehydrogenase isozymes
@ast
The metabolic activation of ab ...... alcohol dehydrogenase isozymes
@en
The metabolic activation of ab ...... alcohol dehydrogenase isozymes
@nl
type
label
The metabolic activation of ab ...... alcohol dehydrogenase isozymes
@ast
The metabolic activation of ab ...... alcohol dehydrogenase isozymes
@en
The metabolic activation of ab ...... alcohol dehydrogenase isozymes
@nl
prefLabel
The metabolic activation of ab ...... alcohol dehydrogenase isozymes
@ast
The metabolic activation of ab ...... alcohol dehydrogenase isozymes
@en
The metabolic activation of ab ...... alcohol dehydrogenase isozymes
@nl
P2093
P1476
The metabolic activation of ab ...... alcohol dehydrogenase isozymes
@en
P2093
John S. Walsh
Linda M. Thurmond
Melinda J. Reese
P304
P356
10.1016/S0009-2797(02)00059-5
P577
2002-11-10T00:00:00Z