cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway
about
M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6A Rap guanine nucleotide exchange factor enriched highly in the basal gangliaJNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extensionA family of cAMP-binding proteins that directly activate Rap1Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with G alpha(i)A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphataseRA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humansPDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interactionProtein phosphorylation cascades associated with methamphetamine-induced glial activation.Membrane-associated guanylate kinase with inverted orientation (MAGI)-1/brain angiogenesis inhibitor 1-associated protein (BAP1) as a scaffolding molecule for Rap small G protein GDP/GTP exchange protein at tight junctionsRA-GEF-1, a guanine nucleotide exchange factor for Rap1, is activated by translocation induced by association with Rap1*GTP and enhances Rap1-dependent B-Raf activationRapgef2 connects GPCR-mediated cAMP signals to ERK activation in neuronal and endocrine cellsSPAL, a Rap-specific GTPase activating protein, is present in the NMDA receptor-PSD-95 complex in the hippocampusRegulation of brain-derived neurotrophic factor exon IV transcription through calcium responsive elements in cortical neuronsDirect binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activationRaf family kinases: old dogs have learned new tricksc-MYC activates protein kinase A (PKA) by direct transcriptional activation of the PKA catalytic subunit beta (PKA-Cbeta) geneThe novel cellular mechanism of human 5-HT6 receptor through an interaction with FynRGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphaoMeaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactionsInsulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes.R-Ras3/M-Ras induces neuronal differentiation of PC12 cells through cell-type-specific activation of the mitogen-activated protein kinase cascade.Mechanism of the spatio-temporal regulation of Ras and Rap1.The strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of Raf to Ras family small GTPasesThe E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradationRit contributes to nerve growth factor-induced neuronal differentiation via activation of B-Raf-extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascadesBromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localizationA unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning proteinEffects of galanin on cocaine-mediated conditioned place preference and ERK signaling in miceRap1a is a key regulator of fibroblast growth factor 2-induced angiogenesis and together with Rap1b controls human endothelial cell functionsDifferential regulation of B-raf isoforms by phosphorylation and autoinhibitory mechanismsThe M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytesInterleukin-6- and cyclic AMP-mediated signaling potentiates neuroendocrine differentiation of LNCaP prostate tumor cells.What links BRAF to the heart function? New insights from the cardiotoxicity of BRAF inhibitors in cancer treatmentThe role of soluble adenylyl cyclase in neurite outgrowthExpression of cAMP-regulated guanine nucleotide exchange factors in pancreatic beta-cells.Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functionsIdentification and characterization of potential effector molecules of the Ras-related GTPase Rap2
P2860
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P2860
cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway
description
1997 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1997
@ast
im April 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1997/04/04)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/04/04)
@nl
наукова стаття, опублікована у квітні 1997
@uk
مقالة علمية (نشرت في 4-4-1997)
@ar
name
cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway
@ast
cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway
@en
cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway
@nl
type
label
cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway
@ast
cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway
@en
cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway
@nl
prefLabel
cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway
@ast
cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway
@en
cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway
@nl
P2093
P1433
P1476
cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway
@en
P2093
P356
10.1016/S0092-8674(00)80184-1
P407
P577
1997-04-04T00:00:00Z