MyD88: an adapter that recruits IRAK to the IL-1 receptor complex
about
The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathwayIRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) familyECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathwayFunctional isoforms of IkappaB kinase alpha (IKKalpha) lacking leucine zipper and helix-loop-helix domains reveal that IKKalpha and IKKbeta have different activation requirementsA phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cellsT6BP, a TRAF6-interacting protein involved in IL-1 signalingCIKS, a connection to Ikappa B kinase and stress-activated protein kinaseIRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stabilityInterleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinaseThe death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascadeSIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanismsRBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradationInterleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosolCharacterization of Pellino2, a substrate of IRAK1 and IRAK4Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-betaAnalysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativityEssential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon-mediated immunityDistinct roles of TIR and non-TIR regions in the subcellular localization and signaling properties of MyD88IRAK-M mediates Toll-like receptor/IL-1R-induced NFκB activation and cytokine productionSIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signalingNF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176NF-kappaB activator Act1 associates with IL-1/Toll pathway adaptor molecule TRAF6TRAF family proteins link PKR with NF-kappa B activationMolecular determinants of NF-kappaB-inducing kinase actionOverexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaBIRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinaseReceptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transductionTransactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathwaySignaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domainIL-1-induced NFkappa B and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK)Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activationPathogen recognition and inflammatory signaling in innate immune defensesThe human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammatBinding specificity of Toll-like receptor cytoplasmic domainsAct1, an NF-kappa B-activating proteinImpact of protein kinase PKR in cell biology: from antiviral to antiproliferative actionRequirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction
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P2860
MyD88: an adapter that recruits IRAK to the IL-1 receptor complex
description
1997 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1997
@ast
im Dezember 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1997/12/01)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/12/01)
@nl
наукова стаття, опублікована в грудні 1997
@uk
مقالة علمية (نشرت في ديسمبر 1997)
@ar
name
MyD88: an adapter that recruits IRAK to the IL-1 receptor complex
@ast
MyD88: an adapter that recruits IRAK to the IL-1 receptor complex
@en
MyD88: an adapter that recruits IRAK to the IL-1 receptor complex
@nl
type
label
MyD88: an adapter that recruits IRAK to the IL-1 receptor complex
@ast
MyD88: an adapter that recruits IRAK to the IL-1 receptor complex
@en
MyD88: an adapter that recruits IRAK to the IL-1 receptor complex
@nl
prefLabel
MyD88: an adapter that recruits IRAK to the IL-1 receptor complex
@ast
MyD88: an adapter that recruits IRAK to the IL-1 receptor complex
@en
MyD88: an adapter that recruits IRAK to the IL-1 receptor complex
@nl
P2093
P3181
P1433
P1476
MyD88: an adapter that recruits IRAK to the IL-1 receptor complex
@en
P2093
P304
P3181
P356
10.1016/S1074-7613(00)80402-1
P407
P577
1997-12-01T00:00:00Z