Studies on the autophosphorylation of the insulin receptor from human placenta. Analysis of the sites phosphorylated by two-dimensional peptide mapping
about
Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase activating proteinInsulin-stimulated kinase from rat fat cells that phosphorylates initiation factor 4E-binding protein 1 on the rapamycin-insensitive site (serine-111)Decreased phosphorylation of mutant insulin receptor by protein kinase C and protein kinase A.Src phosphorylates the insulin-like growth factor type I receptor on the autophosphorylation sites. Requirement for transformation by src.A monoclonal anti-peptide antibody reacting with the insulin receptor beta-subunit. Characterization of the antibody and its epitope and use in immunoaffinity purification of intact receptorsAutophosphorylation of the two C-terminal tyrosine residues Tyr1316 and Tyr1322 modulates the activity of the insulin receptor kinase in vitro.Intrasteric inhibition of ATP binding is not required to prevent unregulated autophosphorylation or signaling by the insulin receptor.Protein-tyrosine phosphatases and the regulation of insulin action.The insulin receptor: signalling mechanism and contribution to the pathogenesis of insulin resistance.The B isoform of the insulin receptor signals more efficiently than the A isoform in HepG2 cells.CSF-1 receptor/insulin receptor chimera permits CSF-1-dependent differentiation of 3T3-L1 preadipocytes.Molecular dynamics of insulin/IGF-I receptor transmembrane signaling.Expression, characterization, and crystallization of the catalytic core of the human insulin receptor protein-tyrosine kinase domain.Multisite serine phosphorylation of the insulin and IGF-I receptors in transfected cells.Changes in insulin-receptor tyrosine, serine and threonine phosphorylation as a result of substitution of tyrosine-1162 with phenylalanine.Evidence that insulin activates casein kinase 2 in rat epididymal fat-cells and that this may result in the increased phosphorylation of an acid-soluble 22 kDa protein.Site-specific anti-phosphopeptide antibodies: use in assessing insulin receptor serine/threonine phosphorylation state and identification of serine-1327 as a novel site of phorbol ester-induced phosphorylation.Insulin receptor and epidermal growth factor receptor dephosphorylation by three major rat liver protein-tyrosine phosphatases expressed in a recombinant bacterial system.Effect of glucagon on insulin receptor phosphorylation in intact liver cells.Association of the insulin receptor and phosphatidylinositol 3-kinase requires a third component.Inhibitory effect of fluoride on insulin receptor autophosphorylation and tyrosine kinase activitySite-specific dephosphorylation and deactivation of the human insulin receptor tyrosine kinase by particulate and soluble phosphotyrosyl protein phosphatases.Identification of serines-967/968 in the juxtamembrane region of the insulin receptor as insulin-stimulated phosphorylation sitesComparison of the effects of insulin and adrenergic agonists on the phosphorylation of an acid-soluble 22 kDa protein in rat epididymal fat-pads and isolated fat-cells.Multi-site phosphorylation of the inhibitory guanine nucleotide regulatory protein Gi-2 occurs in intact rat hepatocytes.Impairment of the liver insulin receptor autoactivation cascade at full-term pregnancy in the rat.Dephosphorylation of insulin-receptor autophosphorylation sites by particulate and soluble phosphotyrosyl-protein phosphatasesCascade of autophosphorylation in the beta-subunit of the insulin receptor.Analysis of insulin-receptor phosphorylation sites in intact cells by two-dimensional phosphopeptide mapping.Evidence for a role for protein kinase C in the stimulation of protein synthesis by insulin in swiss 3T3 fibroblasts.Mutation of tyrosine 960 within the insulin receptor juxtamembrane domain impairs glucose transport but does not inhibit ligand-mediated phosphorylation of insulin receptor substrate-2 in 3T3-L1 adipocytes.Dephosphorylation of autophosphorylated insulin and epidermal-growth-factor receptors by two major subtypes of protein-tyrosine-phosphatase from human placenta.Positive regulation of insulin signaling by neuraminidase 1.Characterization of sites of serine phosphorylation in human placental insulin receptor copurified with insulin-stimulated serine kinase activity by two-dimensional thin-layer peptide mapping.Expression and purification of functional insulin and insulin-like growth factor 1 holoreceptors from mammalian cells.Autophosphorylation of insulin receptorKinase inhibition by a phosphorylated peptide corresponding to the major insulin receptor autophosphorylation domain
P2860
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P2860
Studies on the autophosphorylation of the insulin receptor from human placenta. Analysis of the sites phosphorylated by two-dimensional peptide mapping
description
1988 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1988 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1988
@ast
im Juni 1988 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1988/06/01)
@sk
vědecký článek publikovaný v roce 1988
@cs
wetenschappelijk artikel (gepubliceerd op 1988/06/01)
@nl
наукова стаття, опублікована в червні 1988
@uk
مقالة علمية (نشرت في يونيو 1988)
@ar
name
Studies on the autophosphoryla ...... wo-dimensional peptide mapping
@ast
Studies on the autophosphoryla ...... wo-dimensional peptide mapping
@en
Studies on the autophosphoryla ...... wo-dimensional peptide mapping
@nl
type
label
Studies on the autophosphoryla ...... wo-dimensional peptide mapping
@ast
Studies on the autophosphoryla ...... wo-dimensional peptide mapping
@en
Studies on the autophosphoryla ...... wo-dimensional peptide mapping
@nl
prefLabel
Studies on the autophosphoryla ...... wo-dimensional peptide mapping
@ast
Studies on the autophosphoryla ...... wo-dimensional peptide mapping
@en
Studies on the autophosphoryla ...... wo-dimensional peptide mapping
@nl
P2860
P356
P1433
P1476
Studies on the autophosphoryla ...... wo-dimensional peptide mapping
@en
P2093
J. M. Tavaré
R. M. Denton
P2860
P304
P356
10.1042/BJ2520607
P407
P577
1988-06-01T00:00:00Z