Expression, characterization, and crystallization of the catalytic core of the human insulin receptor protein-tyrosine kinase domain.
about
Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residuesMechanism of activation for Zap-70 catalytic activityTyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formationA surface phospholipase is involved in the migration of plasmodium sporozoites through cellsCrystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanismSmall-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptorMitochondrial respiratory chain is involved in insulin-stimulated hydrogen peroxide production and plays an integral role in insulin receptor autophosphorylation in neuronsCrystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analogRecombinant production of enzymatically active male contraceptive drug target hTSSK2 - Localization of the TSKS domain phosphorylated by TSSK2Dicholine salt of succinic acid, a neuronal insulin sensitizer, ameliorates cognitive deficits in rodent models of normal aging, chronic cerebral hypoperfusion, and beta-amyloid peptide-(25-35)-induced amnesiaEvolution of the vertebrate insulin receptor substrate (Irs) gene familyAutophosphorylation of the two C-terminal tyrosine residues Tyr1316 and Tyr1322 modulates the activity of the insulin receptor kinase in vitro.Intrasteric inhibition of ATP binding is not required to prevent unregulated autophosphorylation or signaling by the insulin receptor.Quantitative phosphoproteomics analysis reveals a key role of insulin growth factor 1 receptor (IGF1R) tyrosine kinase in human sperm capacitationA High-Throughput Radiometric Kinase Assay."DFG-flip" in the insulin receptor kinase is facilitated by a helical intermediate state of the activation loop.Conformational changes in the activation loop of the insulin receptor's kinase domain.The insulin receptor: both a prototypical and atypical receptor tyrosine kinase.The precise sequence of FGF receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations.Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor.Epidermal growth factor and/or growth hormone induce differential, side-specific signal transduction protein phosphorylation in enterocytes.Biochemical characterization of the protein tyrosine kinase homology domain of the ErbB3 (HER3) receptor protein.Perivenous localization of insulin receptor protein in rat liver, and regulation of its expression by glucose and oxygen in hepatocyte cultures.Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70.Role of the PHTH module in protein substrate recognition by Bruton's agammaglobulinemia tyrosine kinase.Insulin stimulates phosphorylation of the beta 2-adrenergic receptor by the insulin receptor, creating a potent feedback inhibitor of its tyrosine kinase.Mitochondrial H2O2 as an enable signal for triggering autophosphorylation of insulin receptor in neurons.Probing the catalytic mechanism of the insulin receptor kinase with a tetrafluorotyrosine-containing peptide substrate.The BPS domain of Grb10 inhibits the catalytic activity of the insulin and IGF1 receptors.Multiple activation loop conformations and their regulatory properties in the insulin receptor's kinase domain.Novel Mechanisms of ALK Activation Revealed by Analysis of the Y1278S Neuroblastoma Mutation.ATP-dependent desensitization of insulin binding and tyrosine kinase activity of the insulin receptor kinase. The role of endosomal acidification.Disruption of the insulin-like growth factor type 1 receptor in osteoblasts enhances insulin signaling and action.Effect of tyrosine mutations on the kinase activity and transforming potential of an oncogenic human insulin-like growth factor I receptor.Structural analysis of the mechanism of phosphorylation of a critical autoregulatory tyrosine residue in FGFR1 kinase domain.
P2860
Q22008806-FBA1FC38-D94F-4AEE-BB48-330F4F2E1419Q24318354-E7BF194F-6258-4CD8-9A71-4DA43E00285BQ24336856-8FA01E10-451F-4207-8D47-E4108C486284Q27230058-CE0250B7-94B5-45FB-8F95-1B35015D7E34Q27629016-8AFAEF67-97AD-4E00-8840-999F8BCEA49BQ27650906-864CA01C-4C83-4C01-B4FD-D0762291B8DFQ28579462-09D8CFAA-30F9-4D03-92D3-0902E4AFBA0EQ29616450-2FAB22ED-80DF-424D-B220-487ADACB9CFAQ30277737-BA7E1C84-D1BF-4BC5-9F8A-D420BC493D73Q33316237-0BD7E4D6-7438-484E-85E3-807A0267A61CQ33830301-772615CE-8C7B-43D3-B79D-B5C48CC404C8Q33913551-01C394F0-E375-45C2-BC04-31B337B84BA0Q33968534-ABA8D40A-77FD-4B77-9612-FA83C828204FQ35325547-232C1D54-5622-4F94-9DDD-4CEDDD3B6AEBQ35821344-C667F352-0C2A-41FD-A980-A1CAB077E72CQ35895098-987A356C-E8B1-4EED-BAB4-2A0E3544BD9CQ36281235-37C46C82-5AFC-4DA9-B1BB-0DD045C3ED3EQ36626691-792BB07D-B1C2-4E80-9BF3-5B7F5299A3D5Q37370492-AB34D1F2-7965-4448-A683-B641476E3B81Q38359478-BD37EA14-19C9-44E6-87FA-3ACB5724E998Q40383991-2016BF84-DF2E-4723-8E2A-8E14783C266FQ41120641-32D39111-A005-450F-9E0E-7F0545A2ECF7Q42093127-CE91C071-81AF-4593-8B7F-25141813EC07Q42481636-E0BC0D76-F967-479D-B619-7B075BAF6A2AQ42510749-2949A636-6194-4AF0-AC50-BD2682CEC11AQ42820023-C4A34DA0-9E5A-418F-94F5-558223BBB8C7Q42921655-066154B6-7E17-41B9-9F41-3BD19FD66A29Q43504461-7D283487-48C8-4378-BE6D-9B31CC10AA43Q43564874-8F542296-C8A0-4640-8C3D-7777F1B2FB27Q43764690-C3E5FCC3-EDB5-4189-B0AB-474642CB3DDAQ47135061-5D55A00C-89A0-43FC-B186-E5C9BFBCC108Q47681831-CBDC0D41-C744-40EA-B8EA-50E1CD96AA6CQ50678899-FFCB4CA9-4967-4E16-9C04-8A64C589AAABQ53457192-FDB98250-14A7-4021-BF86-BA21586E2FCDQ55045564-ABFC82EF-8CDE-41B1-A283-ED42031596DD
P2860
Expression, characterization, and crystallization of the catalytic core of the human insulin receptor protein-tyrosine kinase domain.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Expression, characterization, ...... rotein-tyrosine kinase domain.
@en
type
label
Expression, characterization, ...... rotein-tyrosine kinase domain.
@en
prefLabel
Expression, characterization, ...... rotein-tyrosine kinase domain.
@en
P2093
P2860
P356
P1476
Expression, characterization, ...... rotein-tyrosine kinase domain.
@en
P2093
P2860
P304
P356
10.1074/JBC.270.14.8122
P407
P577
1995-04-01T00:00:00Z