Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation - Wikidata - wikimedia - TriplyDB

Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

http://www.wikidata.org/entity/Q28616026

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Structural and biochemical evaluation of the interaction of the phosphatidylinositol 3-kinase p85alpha Src homology 2 domains with phosphoinositides and inositol polyphosphates Phosphorylation of the PTEN tail regulates protein stability and function UV induces phosphorylation of protein kinase B (Akt) at Ser-473 and Thr-308 in mouse epidermal C1 41 cells through hydrogen peroxide Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo Mechanistic basis of differential cellular responses of phosphatidylinositol 3,4-bisphosphate- and phosphatidylinositol 3,4,5-trisphosphate-binding pleckstrin homology domains Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1 Mechanism of activation of protein kinase B by insulin and IGF-1 The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex Dok-R mediates attenuation of epidermal growth factor-dependent mitogen-activated protein kinase and Akt activation through processive recruitment of c-Src and Csk.Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1 The PI3K-PDK1 connection: more than just a road to PKB Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast.Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides Phosphoinositides: Key modulators of energy metabolism Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change The critical role of Akt in cardiovascular function Expression cloning of protein targets for 3-phosphorylated phosphoinositides Domain swapping used to investigate the mechanism of protein kinase B regulation by 3-phosphoinositide-dependent protein kinase 1 and Ser473 kinase A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases TRAF6 activation of PI 3-kinase-dependent cytoskeletal changes is cooperative with Ras and is mediated by an interaction with cytoplasmic Src.Phosphatidylinositol 3,4,5-trisphosphate localization in recycling endosomes is necessary for AP-1B-dependent sorting in polarized epithelial cells Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation.Signal propagation from membrane messengers to nuclear effectors revealed by reporters of phosphoinositide dynamics and Akt activity Akt-PDK1 complex mediates epidermal growth factor-induced membrane protrusion through Ral activation.Polarization of chemoattractant receptor signaling during neutrophil chemotaxis PI(4,5)P2 regulates myoblast fusion through Arp2/3 regulator localization at the fusion site.Subcellular optogenetic inhibition of G proteins generates signaling gradients and cell migration.Ca(2+)/calmodulin directly interacts with the pleckstrin homology domain of AKT1.The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction.Negative signaling in health and disease.Modular PH and C2 domains in membrane attachment and other functions.DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway.Modulation of cellular apoptotic potential: contributions to oncogenesis.SopB-Mediated Recruitment of SNX18 Facilitates Salmonella Typhimurium Internalization by the Host Cell.Protein targeting to exosomes/microvesicles by plasma membrane anchors Novel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain.Fibroblast growth factor (FGF) signaling through PI 3-kinase and Akt/PKB is required for embryoid body differentiation.Effect of PIP3 on adhesion molecules and adhesion of THP-1 monocytes to HUVEC treated with high glucose

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Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

http://www.wikidata.org/entity/Q28616026

description

1996 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

1996 թվականի մայիսին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 1996

@ast

im Mai 1996 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 1996/05/01)

@sk

vědecký článek publikovaný v roce 1996

@cs

wetenschappelijk artikel (gepubliceerd op 1996/05/01)

@nl

наукова стаття, опублікована в травні 1996

@uk

مقالة علمية (نشرت في مايو 1996)

@ar

name

Specific binding of the Akt-1 ...... without subsequent activation

@ast

Specific binding of the Akt-1 ...... without subsequent activation

@en

Specific binding of the Akt-1 ...... without subsequent activation

@nl

type

label

Specific binding of the Akt-1 ...... without subsequent activation

@ast

Specific binding of the Akt-1 ...... without subsequent activation

@en

Specific binding of the Akt-1 ...... without subsequent activation

@nl

prefLabel

Specific binding of the Akt-1 ...... without subsequent activation

@ast

Specific binding of the Akt-1 ...... without subsequent activation

@en

Specific binding of the Akt-1 ...... without subsequent activation

@nl

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P1433

Biochemical Journal

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Specific binding of the Akt-1 ...... without subsequent activation

@en

P2093

A. B. Holmes

http://www.w3.org/2001/XMLSchema#string

C. P. Downes

http://www.w3.org/2001/XMLSchema#string

D. R. Alessi

http://www.w3.org/2001/XMLSchema#string

R. Gigg

http://www.w3.org/2001/XMLSchema#string

S. J. Grove

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S. R. James

http://www.w3.org/2001/XMLSchema#string

P2860

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase

Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma

Structure of the binding site for inositol phosphates in a PH domain

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils

Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins

Activation of PRK1 by phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. A comparison with protein kinase C isotypes

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

P304

709–713

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scholarly article

P3181

2074014

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P356

10.1042/BJ3150709

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P407

P478

315 ( Pt 3)

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P577

1996-05-01T00:00:00Z

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P5875

14555711

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P698

8645147

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1217264

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