DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway. - Wikidata - wikimedia - TriplyDB

DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway.

DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway.

http://www.wikidata.org/entity/Q33734076

about

DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosis DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1 Parkinson's disease proteins: Novel mitochondrial targets for cardioprotection Mouse models of Parkinson's disease associated with mitochondrial dysfunction Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation Identification of glutathione (GSH)-independent glyoxalase III from Schizosaccharomyces pombe.Expression analysis of dopaminergic neurons in Parkinson's disease and aging links transcriptional dysregulation of energy metabolism to cell death.NRF2 activation restores disease related metabolic deficiencies in olfactory neurosphere-derived cells from patients with sporadic Parkinson's disease Effect of single amino acid substitution on oxidative modifications of the Parkinson's disease-related protein, DJ-1 DJ-1 interacts with and regulates paraoxonase-2, an enzyme critical for neuronal survival in response to oxidative stress.Recent advances in the genetics of Parkinson's disease.Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models Regulation of DJ-1 by Glutaredoxin 1 in Vivo: Implications for Parkinson's Disease.Drosophila DJ-1 decreases neural sensitivity to stress by negatively regulating Daxx-like protein through dFOXO.Molecular profiles of drinking alcohol to intoxication in C57BL/6J mice.Molecular insights into Parkinson's disease.Neuroprotective effect of a new DJ-1-binding compound against neurodegeneration in Parkinson's disease and stroke model rats Age and α-synuclein expression interact to reveal a dependence of dopaminergic axons on endogenous Akt/PKB signaling.Beyond cAMP: The Regulation of Akt and GSK3 by Dopamine Receptors PINK1 enhances insulin-like growth factor-1-dependent Akt signaling and protection against apoptosis.A DJ-1 Based Peptide Attenuates Dopaminergic Degeneration in Mice Models of Parkinson's Disease via Enhancing Nrf2.Neuroprotective Effect of a DJ-1 Based Peptide in a Toxin Induced Mouse Model of Multiple System Atrophy.Amino-Nogo-A antagonizes reactive oxygen species generation and protects immature primary cortical neurons from oxidative toxicity.Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures Role of renal DJ-1 in the pathogenesis of hypertension associated with increased reactive oxygen species production S-Nitrosoglutathione Reductase Plays Opposite Roles in SH-SY5Y Models of Parkinson's Disease and Amyotrophic Lateral Sclerosis Activation of transcription factor MEF2D by bis(3)-cognitin protects dopaminergic neurons and ameliorates Parkinsonian motor defects.Premotor biomarkers for Parkinson's disease - a promising direction of research.Comparative mRNA Expression of eEF1A Isoforms and a PI3K/Akt/mTOR Pathway in a Cellular Model of Parkinson's Disease Overexpression of DJ-1 reduces oxidative stress and attenuates hypoxia/reoxygenation injury in NRK-52E cells exposed to high glucose.DJ-1 Expression in Cervical Carcinoma and its Effects on Cell Viability and Apoptosis High-expression of DJ-1 and loss of PTEN associated with tumor metastasis and correlated with poor prognosis of gastric carcinoma Increased expression of macrophage migration inhibitory factor and DJ-1 contribute to cell invasion and metastasis of nasopharyngeal carcinoma.DJ-1 protects against cell death following acute cardiac ischemia-reperfusion injury.DJ-1 promotes development of DEN-induced hepatocellular carcinoma and proliferation of liver cancer cells.BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage.

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P2860

DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway.

http://www.wikidata.org/entity/Q33734076

description

2010 nî lūn-bûn

@nan

2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

@zh-tw

2010年论文

@wuu

name

DJ-1 protects the nigrostriata ...... modulation of the AKT pathway.

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DJ-1 protects the nigrostriata ...... modulation of the AKT pathway.

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type

label

DJ-1 protects the nigrostriata ...... modulation of the AKT pathway.

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DJ-1 protects the nigrostriata ...... modulation of the AKT pathway.

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prefLabel

DJ-1 protects the nigrostriata ...... modulation of the AKT pathway.

@ast

DJ-1 protects the nigrostriata ...... modulation of the AKT pathway.

@en

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PNAS.0914876107

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Proceedings of the National Academy of Sciences of the United States of America

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DJ-1 protects the nigrostriata ...... modulation of the AKT pathway

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P2093

Isabella Irrcher

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Mohammad Parsanejad

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Patrizia Rizzu

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Raymond H Kim

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Ruth S Slack

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Sarah J Hewitt

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Steve M Callaghan

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Tak W Mak

http://www.w3.org/2001/XMLSchema#string

P2860

DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis

Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition

DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

DJ-1 has a role in antioxidative stress to prevent cell death

Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism

P304

3186-3191

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10.1073/PNAS.0914876107

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7

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107

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Alvin P Joselin

Paul C Marcogliese

Hossein Aleyasin

Maxime Rousseaux

P577

2010-01-26T00:00:00Z

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41408547

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20133695

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2840364

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