Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein. - Wikidata - wikimedia - TriplyDB

Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein.

Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein.

http://www.wikidata.org/entity/Q28648056

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Regulation of mixed lineage kinase 3 is required for Neurofibromatosis-2-mediated growth suppression in human cancer Raf family kinases: old dogs have learned new tricks Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma The neurofibromatosis 2 tumor suppressor gene product, merlin, regulates human meningioma cell growth by signaling through YAP MLK3 Signaling in Cancer Invasion Neurofibromatosis type 2 protein, NF2: an uncoventional cell cycle regulator.The tumor suppressor merlin is required for cell cycle exit, terminal differentiation, and cell polarity in the developing murine lens Epidermal RAF prevents allergic skin disease p75NTR is highly expressed in vestibular schwannomas and promotes cell survival by activating nuclear transcription factor κB.Inhibition of c-Jun N-terminal kinase activity enhances vestibular schwannoma cell sensitivity to gamma irradiation.NF2/merlin in hereditary neurofibromatosis 2 versus cancer: biologic mechanisms and clinical associations.Contribution of persistent C-Jun N-terminal kinase activity to the survival of human vestibular schwannoma cells by suppression of accumulation of mitochondrial superoxides.The ErbB inhibitors trastuzumab and erlotinib inhibit growth of vestibular schwannoma xenografts in nude mice: a preliminary study Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointestinal tumours.The mixed-lineage kinase 1-3 signalling pathway regulates stress response in cardiac myocytes via GATA-4 and AP-1 transcription factors Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors.p21-Activated kinases are required for transformation in a cell-based model of neurofibromatosis type 2.Deducing corticotropin-releasing hormone receptor type 1 signaling networks from gene expression data by usage of genetic algorithms and graphical Gaussian models NF2-deficient cells depend on the Rac1-canonical Wnt signaling pathway to promote the loss of contact inhibition of proliferation.Mammalian Ste20-like kinase (Mst2) indirectly supports Raf-1/ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylation Adjunctive and long-acting nanoformulated antiretroviral therapies for HIV-associated neurocognitive disorders MLK3 is a direct target of biochanin A, which plays a role in solar UV-induced COX-2 expression in human keratinocytes.Inhibition of Cdc42-mediated activation of mixed lineage kinase 3 by the tumor suppressor protein merlin.Dissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation Metabolic stress signaling mediated by mixed-lineage kinases.Mixed lineage kinase 3 is required for matrix metalloproteinase expression and invasion in ovarian cancer cells Loss of MLK3 signaling impedes ulcer healing by modulating MAPK signaling in mouse intestinal mucosa.GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation Raf kinases: oncogenesis and drug discovery.Mixed lineage kinases (MLKs): a role in dendritic cells, inflammation and immunity?Neuropathology for the neuroradiologist: Antoni A and Antoni B tissue patterns.MLK3 limits activated Galphaq signaling to Rho by binding to p63RhoGEF.The PP2C Alphabet is a negative regulator of stress-activated protein kinase signaling in Drosophila.Mixed Lineage Kinase-c-Jun N-Terminal Kinase Axis: A Potential Therapeutic Target in Cancer.Merlin is a potent inhibitor of glioma growth Mixed lineage kinase 3 negatively regulates IKK activity and enhances etoposide-induced cell death Mechanistic principles of RAF kinase signaling.Involvement of mixed lineage kinase 3 in cancer.MLK3 is part of a feedback mechanism that regulates different cellular responses to reactive oxygen species.The secret life of kinases: functions beyond catalysis

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Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein.

http://www.wikidata.org/entity/Q28648056

description

2006 nî lūn-bûn

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2006 թուականի Մարտին հրատարակուած գիտական յօդուած

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2006 թվականի մարտին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

@zh-hk

2006年論文

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2006年論文

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2006年论文

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name

Mixed-lineage kinase 3 regulat ...... e NF2 tumor suppressor protein

@nl

Mixed-lineage kinase 3 regulat ...... NF2 tumor suppressor protein.

@ast

Mixed-lineage kinase 3 regulat ...... NF2 tumor suppressor protein.

@en

type

label

Mixed-lineage kinase 3 regulat ...... e NF2 tumor suppressor protein

@nl

Mixed-lineage kinase 3 regulat ...... NF2 tumor suppressor protein.

@ast

Mixed-lineage kinase 3 regulat ...... NF2 tumor suppressor protein.

@en

prefLabel

Mixed-lineage kinase 3 regulat ...... e NF2 tumor suppressor protein

@nl

Mixed-lineage kinase 3 regulat ...... NF2 tumor suppressor protein.

@ast

Mixed-lineage kinase 3 regulat ...... NF2 tumor suppressor protein.

@en

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PNAS.0510651103

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Proceedings of the National Academy of Sciences of the United States of America

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Mixed-lineage kinase 3 regulat ...... e NF2 tumor suppressor protein

@en

P2093

Ali Andalibi

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David J Lim

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Deborah N Chadee

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Gene Hung

http://www.w3.org/2001/XMLSchema#string

John M Kyriakis

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Zhijun Luo

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P2860

MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation

Endothelial apoptosis in Braf-deficient mice

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

MEK kinase activity is not necessary for Raf-1 function.

Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors

Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis

Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation

Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades.

Positive and negative regulation of Raf kinase activity and function by phosphorylation.

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4463-4468

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51555

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10.1073/PNAS.0510651103

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12

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103

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David H Gutmann

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7241929

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16537381

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