MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation
about
Regulation of mixed lineage kinase 3 is required for Neurofibromatosis-2-mediated growth suppression in human cancerNaturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitorsDissection of a signaling pathway by which pathogen-associated molecular patterns recruit the JNK and p38 MAPKs and trigger cytokine releaseMixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathwaysTNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathwayMLK3 Signaling in Cancer InvasionComplete inhibition of anisomycin and UV radiation but not cytokine induced JNK and p38 activation by an aryl-substituted dihydropyrrolopyrazole quinoline and mixed lineage kinase 7 small interfering RNAMolecular mechanisms of liver injury and hepatocarcinogenesis: focusing on the role of stress-activated MAPKMixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein.Epidermal RAF prevents allergic skin diseaseCdc42 induces activation loop phosphorylation and membrane targeting of mixed lineage kinase 3.p75NTR is highly expressed in vestibular schwannomas and promotes cell survival by activating nuclear transcription factor κB.Inhibition of c-Jun N-terminal kinase activity enhances vestibular schwannoma cell sensitivity to gamma irradiation.Contribution of persistent C-Jun N-terminal kinase activity to the survival of human vestibular schwannoma cells by suppression of accumulation of mitochondrial superoxides.Cysteine-rich secretory protein 2 binds to mitogen-activated protein kinase kinase kinase 11 in mouse sperm.Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointestinal tumours.Mixed lineage kinase-3/JNK1 axis promotes migration of human gastric cancer cells following gastrin stimulation.The mixed-lineage kinase 1-3 signalling pathway regulates stress response in cardiac myocytes via GATA-4 and AP-1 transcription factorsMixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors.Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cellsRole of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades.Mammalian Ste20-like kinase (Mst2) indirectly supports Raf-1/ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylationMixed-lineage kinase 3 deficiency promotes neointima formation through increased activation of the RhoA pathway in vascular smooth muscle cellsMixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cellsThe E3 ligase CHIP mediates ubiquitination and degradation of mixed-lineage kinase 3Blimp1 activation by AP-1 in human lung cancer cells promotes a migratory phenotype and is inhibited by the lysyl oxidase propeptide.MLK3 is a direct target of biochanin A, which plays a role in solar UV-induced COX-2 expression in human keratinocytes.Inhibition of Cdc42-mediated activation of mixed lineage kinase 3 by the tumor suppressor protein merlin.Genetic analysis of slipper/mixed lineage kinase reveals requirements in multiple Jun-N-terminal kinase-dependent morphogenetic events during Drosophila development.Dissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutationMLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in miceFamilial cutaneous lupus erythematosus (CLE) in the German shorthaired pointer maps to CFA18, a canine orthologue to human CLEPAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulationMetabolic stress signaling mediated by mixed-lineage kinases.Mixed lineage kinase 3 is required for matrix metalloproteinase expression and invasion in ovarian cancer cellsMLK4β functions as a negative regulator of MAPK signaling and cell invasionLoss of MLK3 signaling impedes ulcer healing by modulating MAPK signaling in mouse intestinal mucosa.MAP3K11 is a tumor suppressor targeted by the oncomiR miR-125b in early B cells.GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferationRegulation of MAPKs by growth factors and receptor tyrosine kinases
P2860
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P2860
MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation
description
2004 nî lūn-bûn
@nan
2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation
@ast
MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation
@en
MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation
@en-gb
MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation
@nl
type
label
MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation
@ast
MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation
@en
MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation
@en-gb
MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation
@nl
prefLabel
MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation
@ast
MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation
@en
MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation
@en-gb
MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation
@nl
P2860
P3181
P356
P1433
P1476
MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation
@en
P2093
Deborah N Chadee
John M Kyriakis
P2860
P2888
P3181
P356
10.1038/NCB1152
P407
P577
2004-08-01T00:00:00Z
P6179
1027807835