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Axonal transport and neurodegenerative disease: can we see the elephant?

Axonal transport and neurodegenerative disease: can we see the elephant?

http://www.wikidata.org/entity/Q28661055

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Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration Drive the Car(go)s-New Modalities to Control Cargo Trafficking in Live Cells Amyloid-β oligomers induce tau-independent disruption of BDNF axonal transport via calcineurin activation in cultured hippocampal neurons The intricate relationship between microtubules and their associated motor proteins during axon growth and maintenance.A PIK3C3-ankyrin-B-dynactin pathway promotes axonal growth and multiorganelle transport.Dendritic and axonal mechanisms of Ca2+ elevation impair BDNF transport in Aβ oligomer-treated hippocampal neurons Alzheimer's disease in a dish: promises and challenges of human stem cell models.Signaling Over Distances.Back to the tubule: microtubule dynamics in Parkinson's disease.Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier.UV irradiation accelerates amyloid precursor protein (APP) processing and disrupts APP axonal transport.Pathophysiology Associated with Traumatic Brain Injury: Current Treatments and Potential Novel Therapeutics.Modulation of GLP-1 signaling as a novel therapeutic approach in the treatment of Alzheimer's disease pathology.Mitochondrial Metabolism Power SIRT2-Dependent Deficient Traffic Causing Alzheimer's-Disease Related Pathology.Managing intracellular transport.Soluble N-terminal fragment of mutant Huntingtin protein impairs mitochondrial axonal transport in cultured hippocampal neurons.Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons.KymoAnalyzer: a software tool for the quantitative analysis of intracellular transport in neurons.Human Induced Pluripotent Stem Cells and the Modelling of Alzheimer's Disease: The Human Brain Outside the Dish.A small-molecule activator of kinesin-1 drives remodeling of the microtubule network.Effects of mild running on substantia nigra during early neurodegeneration.Atlas stumbled: kinesin light chain-1 variant E triggers a vicious cycle of axonal transport disruption and amyloid-β generation in Alzheimer's disease.Differential effect of amyloid beta peptides on mitochondrial axonal trafficking depends on their state of aggregation and binding to the plasma membrane.

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Axonal transport and neurodegenerative disease: can we see the elephant?

http://www.wikidata.org/entity/Q28661055

description

2012 nî lūn-bûn

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2012 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Axonal transport and neurodegenerative disease: can we see the elephant?

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Axonal transport and neurodegenerative disease: can we see the elephant?

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Axonal transport and neurodegenerative disease: can we see the elephant?

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Axonal transport and neurodegenerative disease: can we see the elephant?

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Axonal transport and neurodegenerative disease: can we see the elephant?

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Axonal transport and neurodegenerative disease: can we see the elephant?

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Axonal transport and neurodegenerative disease: can we see the elephant?

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Axonal transport and neurodegenerative disease: can we see the elephant?

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Axonal transport and neurodegenerative disease: can we see the elephant?

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J.PNEUROBIO.2012.03.006

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Progress in Neurobiology

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Axonal transport and neurodegenerative disease: can we see the elephant?

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Lawrence S B Goldstein

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APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path

A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin

A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10)

Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein.

Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

Interaction of huntingtin-associated protein with dynactin P150Glued

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10.1016/J.PNEUROBIO.2012.03.006

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22484448

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neurodegeneration

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3867006

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