NQO1-dependent redox cycling of idebenone: effects on cellular redox potential and energy levels - Wikidata - wikimedia - TriplyDB

NQO1-dependent redox cycling of idebenone: effects on cellular redox potential and energy levels

NQO1-dependent redox cycling of idebenone: effects on cellular redox potential and energy levels

http://www.wikidata.org/entity/Q28741474

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New Therapeutic Concept of NAD Redox Balance for Cisplatin Nephrotoxicity Mitochondrial disorders in children: toward development of small-molecule treatment strategies Idebenone and neuroprotection: antioxidant, pro-oxidant, or electron carrier?The ToxBank Data Warehouse: Supporting the Replacement of In Vivo Repeated Dose Systemic Toxicity Testing Idebenone protects against retinal damage and loss of vision in a mouse model of Leber's hereditary optic neuropathy Is there treatment for Leber hereditary optic neuropathy?Features of idebenone and related short-chain quinones that rescue ATP levels under conditions of impaired mitochondrial complex I Loss of dihydrolipoyl succinyltransferase (DLST) leads to reduced resting heart rate in the zebrafish.Augmentation of NAD(+) by NQO1 attenuates cisplatin-mediated hearing impairment.The effects of idebenone on mitochondrial bioenergetics A randomized placebo-controlled trial of idebenone in Leber's hereditary optic neuropathy.The optic nerve: a "mito-window" on mitochondrial neurodegeneration Effects of idebenone on color vision in patients with leber hereditary optic neuropathy.The mixture of "ecstasy" and its metabolites is toxic to human SH-SY5Y differentiated cells at in vivo relevant concentrations.White matter consequences of retinal receptor and ganglion cell damage.The podocyte power-plant disaster and its contribution to glomerulopathy.A Female Patient with Down Syndrome and Low-Penetrance Leber's Hereditary Optic Neuropathy.Mitochondrial function in human neuroblastoma cells is up-regulated and protected by NQO1, a plasma membrane redox enzyme.2-deoxy-D-glucose enhances anesthetic effects in mice Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells Leber Hereditary Optic Neuropathy - Therapeutic Challenges and Early Promise.Disorders of the optic nerve in mitochondrial cytopathies: new ideas on pathogenesis and therapeutic targets.Natural Product Screening Reveals Naphthoquinone Complex I Bypass Factors.How mitochondrial dysfunction affects zebrafish development and cardiovascular function: an in vivo model for testing mitochondria-targeted drugs.Mitochondrial diaphorases as NAD⁺ donors to segments of the citric acid cycle that support substrate-level phosphorylation yielding ATP during respiratory inhibition.Treatment of hereditary optic neuropathies.Chemical and technological delivery systems for idebenone: a review of literature production.Novel therapeutic approaches for Leber's hereditary optic neuropathy.SEURAT-1 liver gold reference compounds: a mechanism-based review.Border between natural product and drug: comparison of the related benzoquinones idebenone and coenzyme Q10 Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations In Vitro Antioxidant Activity of Idebenone Derivative-Loaded Solid Lipid Nanoparticles.Idebenone: A Review in Leber's Hereditary Optic Neuropathy.A Review of Mitochondrial Optic Neuropathies: From Inherited to Acquired Forms Therapeutic strategies for Leber's hereditary optic neuropathy: A current update.Peroxiredoxin 1 knockdown potentiates β-lapachone cytotoxicity through modulation of reactive oxygen species and mitogen-activated protein kinase signals.Effects of glucocorticoids and idebenone on respiratory function in patients with duchenne muscular dystrophy.Leber Hereditary Optic Neuropathy: A Mitochondrial Disease Unique in Many Ways.The hypoxia-induced dehydrogenase HorA is required for coenzyme Q10 biosynthesis, azole sensitivity and virulence of Aspergillus fumigatus.Mitochondrial biogenesis and neural differentiation of human iPSC is modulated by idebenone in a developmental stage-dependent manner.

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NQO1-dependent redox cycling of idebenone: effects on cellular redox potential and energy levels

http://www.wikidata.org/entity/Q28741474

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Anja C Gemperli

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Corinne Anklin

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Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species. Implications for the use of exogenous ubiquinones as therapies and experimental tools

Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia

Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a dihydronicotinamide riboside dependent oxidoreductase

NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector

An alternatively spliced form of NQO1 (DT-diaphorase) messenger RNA lacking the putative quinone substrate binding site is present in human normal and tumor tissues

Treatment of CoQ(10) deficient fibroblasts with ubiquinone, CoQ analogs, and vitamin C: time- and compound-dependent effects

Bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by human NAD(P)H quinone oxidoreductase 2: a novel co-substrate-mediated antitumor prodrug therapy

A critical appraisal of the mitochondrial coenzyme Q pool.

NRH:quinone oxidoreductase2 (NQO2).

Antioxidant use in Friedreich ataxia

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