Anti-transforming growth factor ß antibody treatment rescues bone loss and prevents breast cancer metastasis to bone
about
Regulation of postnatal bone homeostasis by TGFβBone specific immunity and its impact on metastasisDoxorubicin-mediated bone loss in breast cancer bone metastases is driven by an interplay between oxidative stress and induction of TGFβPredictive computational modeling to define effective treatment strategies for bone metastatic prostate cancer.Complexities of TGF-β targeted cancer therapy.Molecular mechanisms of bone metastasis and associated muscle weakness.Wnt signaling induces gene expression of factors associated with bone destruction in lung and breast cancer.The role of cytokines in breast cancer development and progressionPhase I study of GC1008 (fresolimumab): a human anti-transforming growth factor-beta (TGFβ) monoclonal antibody in patients with advanced malignant melanoma or renal cell carcinoma.Dimorphic effects of transforming growth factor-β signaling during aortic aneurysm progression in mice suggest a combinatorial therapy for Marfan syndromeBone-Targeted Agents for the Management of Breast Cancer Patients with Bone MetastasesExcess TGF-β mediates muscle weakness associated with bone metastases in mice.Matrix rigidity regulates the transition of tumor cells to a bone-destructive phenotype through integrin β3 and TGF-β receptor type II.E-selectin ligand 1 regulates bone remodeling by limiting bioactive TGF-β in the bone microenvironmentLoss of Nrf2 accelerates ionizing radiation-induced bone loss by upregulating RANKL.Bone marrow mesenchymal stem cells and TGF-β signaling in bone remodeling.Role of TGF-β in breast cancer bone metastases.Contributions of the host microenvironment to cancer-induced bone disease.Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow.Growth factor signaling in metastasis: current understanding and future opportunities.Bone marrow microenvironment in cancer patients: immunological aspects and clinical implications.The role of TGF-β in bone metastasis: novel therapeutic perspectives.Biomechanics of TGFβ-induced epithelial-mesenchymal transition: implications for fibrosis and cancerCombined treatment with a transforming growth factor beta inhibitor (1D11) and bortezomib improves bone architecture in a mouse model of myeloma-induced bone disease.Adaptive metabolic rewiring to chronic SFK inhibitionCCT6A suppresses SMAD2 and promotes prometastatic TGF-β signaling.Gremlin promotes peritoneal membrane injury in an experimental mouse model and is associated with increased solute transport in peritoneal dialysis patients.Hallmarks of Bone Metastasis.Transforming growth factor-β in stem cells and tissue homeostasis.
P2860
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P2860
Anti-transforming growth factor ß antibody treatment rescues bone loss and prevents breast cancer metastasis to bone
description
2011 nî lūn-bûn
@nan
2011 թուականին հրատարակուած գիտական յօդուած
@hyw
2011 թվականին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Anti-transforming growth facto ...... east cancer metastasis to bone
@ast
Anti-transforming growth facto ...... east cancer metastasis to bone
@en
Anti-transforming growth facto ...... east cancer metastasis to bone
@nl
type
label
Anti-transforming growth facto ...... east cancer metastasis to bone
@ast
Anti-transforming growth facto ...... east cancer metastasis to bone
@en
Anti-transforming growth facto ...... east cancer metastasis to bone
@nl
prefLabel
Anti-transforming growth facto ...... east cancer metastasis to bone
@ast
Anti-transforming growth facto ...... east cancer metastasis to bone
@en
Anti-transforming growth facto ...... east cancer metastasis to bone
@nl
P2093
P2860
P3181
P1433
P1476
Anti-transforming growth facto ...... east cancer metastasis to bone
@en
P2093
Anwesa Chakrabarti
Austin Ayres
Gregory R Mundy
James Edwards
Jeffry S Nyman
JoAnn Alvarez
Julie Sterling
Lynn M Matrisian
Rachelle Johnson
Scott Lonning
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0027090
P407
P577
2011-01-01T00:00:00Z