Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment.
about
Role of hypoxia-inducible factors in breast cancer metastasisCancer-stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasisMesenchymal stem cell secretome and regenerative therapy after cancerTGF-β/SMAD/GLI2 signaling axis in cancer progression and metastasisOmentum and bone marrow: how adipocyte-rich organs create tumour microenvironments conducive for metastatic progressionImplications of Hypoxia in Breast Cancer Metastasis to BoneNEDD9 crucially regulates TGF-β-triggered epithelial-mesenchymal transition and cell invasion in prostate cancer cells: involvement in cancer progressivenessHypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cellsAnti-transforming growth factor ß antibody treatment rescues bone loss and prevents breast cancer metastasis to boneThe TGF-β Signaling Regulator PMEPA1 Suppresses Prostate Cancer Metastases to BoneThe endochondral bone protein CHM1 sustains an undifferentiated, invasive phenotype, promoting lung metastasis in Ewing sarcoma.TGF-beta-RI kinase inhibitor SD-208 reduces the development and progression of melanoma bone metastasesVincristine enhances amoeboid-like motility via GEF-H1/RhoA/ROCK/Myosin light chain signaling in MKN45 cellsSkeletal muscle Ca(2+) mishandling: Another effect of bone-to-muscle signaling.Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapiesCXCR4/SDF1 mediate hypoxia induced chondrosarcoma cell invasion through ERK signaling and increased MMP1 expressionMolecular mechanisms of bone metastasis and associated muscle weakness.MicroRNAs in the control of metastatic bone disease.In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropic metastasis of breast cancer.Reversal of chemotherapy-induced leukopenia using granulocyte macrophage colony-stimulating factor promotes bone metastasis that can be blocked with osteoclast inhibitorsMolecular pathogenesis of bone metastases in breast cancer: Proven and emerging therapeutic targetsHypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis.Inhibition of metastasis in a castration resistant prostate cancer model by the quinoline-3-carboxamide tasquinimod (ABR-215050).Identification of microRNAs inhibiting TGF-β-induced IL-11 production in bone metastatic breast cancer cells.Osteoclasts in multiple myeloma are derived from Gr-1+CD11b+myeloid-derived suppressor cells.The role of cytokines in breast cancer development and progressionTGF-β signaling in breast cancer cell invasion and bone metastasis.Bone resorption facilitates osteoblastic bone metastatic colonization by cooperation of insulin-like growth factor and hypoxia.The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells.Modeling TGF-β in early stages of cancer tissue dynamics.Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype.ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment.Hypoxia, stem cells and bone tumorTherapeutic targets for bone metastases in breast cancer.Bone marrow as a metastatic niche for disseminated tumor cells from solid tumors.TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growthMouse models of advanced spontaneous metastasis for experimental therapeutics.NHERF1 acts as a molecular switch to program metastatic behavior and organotropism via its PDZ domains.miR-181a Targets RGS16 to Promote Chondrosarcoma Growth, Angiogenesis, and Metastasis.Excess TGF-β mediates muscle weakness associated with bone metastases in mice.
P2860
Q26860122-43447D17-4DB6-4782-BC0C-49CF5B12BB85Q26866144-46B46F92-DC30-4AE4-A671-EFC534A48C4EQ27007499-0521707D-ACA5-407F-8AB9-45947E62E646Q27008239-537A4326-69B7-4F8B-BDA6-0833B6FC83CFQ28076686-43F08E0F-7144-45B4-8DE0-17733C6D10CBQ28077444-842D919D-81FF-41EB-AB44-3DE4F100F40DQ28238097-236D464D-9EE7-4CC5-8A07-3FE0E1CFAD45Q28393898-56215B9E-2F2F-4F2D-B62C-FB36B984D247Q28742851-4EC52247-384F-490D-BC4C-2A2811D01AC5Q30299930-6F393C15-6888-4637-9E82-E98C2CCC1871Q30313322-7FE9BD6C-B4D4-4199-B5F7-EB8D1136216FQ30429041-C21B403A-E24D-4066-A2CC-B164799CB4F2Q30529813-669B6AEB-A4F3-4F91-97EC-532E0437B3E8Q33602302-680694B0-532C-4582-976C-C700BFBBA147Q33628894-78D3B3FB-B5F6-4963-AE96-B1E78C8770E8Q33672265-DB1B2901-EBD5-47B3-884F-7B844583DB85Q33758508-C981162B-C009-4E25-9913-8C122AF18768Q33821326-A6ADFE66-A827-462A-8C89-CB9B51E48159Q33857991-665C999E-8805-4E98-953A-5DCF99886D29Q33926132-E8279839-ABC9-4D0F-8FC1-00412594AFE3Q34023663-078F0F73-204E-4127-A972-69EE3FF35D19Q34025482-07D2816D-54C1-495D-A6EB-62BE621C95A5Q34250496-1B123FD0-E149-4A8D-9B42-5C20CF82A954Q34281856-26DA34AA-9C23-48A6-8471-213375CF8EF5Q34485147-CF780112-4E35-4357-B7B8-97A6A37A1BCEQ34920381-3F8D9956-0774-45F9-AA34-06F157B67A07Q34985004-37FB9A5A-031F-44FE-AC03-6560A1EA6ABCQ35051528-DFF72DE5-21B6-4606-9041-481C802DBA74Q35079440-872BFB5B-CE38-46ED-B1C7-C0D3CBF47EFBQ35106118-C5243001-7D9B-457A-8C44-64A429EEE098Q35149689-28AB6E2B-7288-42A8-AC05-584522574519Q35377107-125F02E1-8B6C-412C-B0E4-54D1A2F0B45CQ35549238-FC10BEE4-7822-4A83-9515-879D943A441EQ35558919-639A3892-5D0A-4969-AF3B-DB88ACC56EDAQ35632622-4B863D9B-82DE-4A2C-8B01-195218019459Q35826016-F450C3B0-BAB0-4A5E-9D66-E47FE615B4FCQ35966786-CA3C8EB4-B3D0-47AA-98C7-AE29851AFE8EQ35998570-7703ED68-825F-4D34-9756-D0C6C241E3BFQ36068725-2816A2C5-FCFA-4B76-8C6A-AF046CB0F57AQ36258000-3F864D68-9EAF-4E72-996A-F0024596B4AA
P2860
Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment.
description
2009 nî lūn-bûn
@nan
2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Hypoxia and TGF-beta drive bre ...... and the bone microenvironment
@nl
Hypoxia and TGF-beta drive bre ...... and the bone microenvironment.
@ast
Hypoxia and TGF-beta drive bre ...... and the bone microenvironment.
@en
Hypoxia and TGF-beta drive bre ...... and the bone microenvironment.
@en-gb
type
label
Hypoxia and TGF-beta drive bre ...... and the bone microenvironment
@nl
Hypoxia and TGF-beta drive bre ...... and the bone microenvironment.
@ast
Hypoxia and TGF-beta drive bre ...... and the bone microenvironment.
@en
Hypoxia and TGF-beta drive bre ...... and the bone microenvironment.
@en-gb
prefLabel
Hypoxia and TGF-beta drive bre ...... and the bone microenvironment
@nl
Hypoxia and TGF-beta drive bre ...... and the bone microenvironment.
@ast
Hypoxia and TGF-beta drive bre ...... and the bone microenvironment.
@en
Hypoxia and TGF-beta drive bre ...... and the bone microenvironment.
@en-gb
P2093
P2860
P3181
P1433
P1476
Hypoxia and TGF-beta drive bre ...... and the bone microenvironment.
@en
P2093
C Ryan McKenna
Holly W Davis
John M Chirgwin
Khalid S Mohammad
Lauren K Dunn
Maria Niewolna
Xiang Hong Peng
P2860
P3181
P356
10.1371/JOURNAL.PONE.0006896
P407
P577
2009-09-03T00:00:00Z