Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin - Wikidata - wikimedia - TriplyDB

Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin

Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin

http://www.wikidata.org/entity/Q28752238

about

sameAs

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function.Novel mitochondrial substrates of omi indicate a new regulatory role in neurodegenerative disorders.Mitochondrial quality control: insights on how Parkinson's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis.PINK1/Parkin-Dependent Mitochondrial Surveillance: From Pleiotropy to Parkinson's Disease.Drosophila melanogaster in the study of human neurodegeneration.Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1.Drosophila models of Parkinson's disease: discovering relevant pathways and novel therapeutic strategies.A link between impaired purine nucleotide synthesis and apoptosis in Drosophila melanogaster.Methamphetamine causes mitrochondrial oxidative damage in human T lymphocytes leading to functional impairment The complex I subunit NDUFA10 selectively rescues Drosophila pink1 mutants through a mechanism independent of mitophagy.Effect of lysosomal and ubiquitin-proteasome system dysfunction on the abnormal aggregation of α-synuclein in PC12 cells.Silent information regulator 2 (Sir2) and Forkhead box O (FOXO) complement mitochondrial dysfunction and dopaminergic neuron loss in Drosophila PTEN-induced kinase 1 (PINK1) null mutant TRAP1 rescues PINK1 loss-of-function phenotypes.The PARL family of mitochondrial rhomboid proteases.New animal models of Parkinson's disease.Parkin, PINK1 and mitochondrial integrity: emerging concepts of mitochondrial dysfunction in Parkinson's disease.Mitochondrial quality control: a matter of life and death for neurons.Function and characteristics of PINK1 in mitochondria.Therapeutic strategies in Parkinson's disease: what we have learned from animal models.Compromised MAPK signaling in human diseases: an update.Germ cell connectivity enhances cell death in response to DNA damage in the Drosophila testis.Apoptosis in Drosophila: which role for mitochondria?Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations.VPS35 pathogenic mutations confer no dominant toxicity but partial loss of function in Drosophila and genetically interact with parkin.Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss.Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease.Drosophila PINK1 and parkin loss-of-function mutants display a range of non-motor Parkinson's disease phenotypes.HtrA2 deficiency causes mitochondrial uncoupling through the F₁F₀-ATP synthase and consequent ATP depletion.The HtrA2 Drosophila model of Parkinson's disease is suppressed by the pro-survival Bcl-2 Buffy.Mitochondrial Quality Control in Neurodegenerative Diseases: Focus on Parkinson's Disease and Huntington's Disease.Mitochondrial dysfunction in Parkinson's disease

P2860

5f5ba67e54f4ea6658537c83f774cc714fc83ae5 6af49bef790d7e99ccb488ef20fa3d70276a0731

P248

Q21145802-7CBDD47C-D902-4002-A832-D584FB55F588 Q24316726-EB275B5A-4122-47CE-9D0E-AB7C9DB01A1F Q24337079-F924CFCF-33BB-497F-98C9-C67203E00D42 Q28117215-B3B97680-0B75-4F0B-B7B7-E1386E2DABEB Q30495575-F75F61A2-F4C5-467A-BAC6-AC475977ADEC Q33504585-BA1D2DB4-6E2D-46A6-9AD5-412E90C8908D Q33603972-FE161B8B-3D3C-4D1F-A055-5436F4F432BF Q33619324-34FA139A-69D7-4476-BB70-59C8BFC5FDDC Q34022667-82ADF1DD-314A-4490-B8DF-39DAEC2B9B70 Q34713631-2722AA4A-E614-4EDB-9231-D8DAA13718A6 Q34787767-05F7D496-C01F-4E98-B339-72DC6664AEA0 Q35065493-1E95709E-7B12-458F-911A-C4E37A256E3A Q35073066-D1BA5370-7C66-4702-8034-013F6B2AF2E4 Q35439664-2C65B092-CFAE-482D-80D3-173752A9A032 Q35681438-BC6FE044-D8CD-4CF2-BCA2-7D6C42687720 Q35921597-F8689585-FE7A-4EA0-8FA1-D0C7DA3DA66B Q36950677-01EF6FDB-4BA7-42A6-A66A-DE904B4B8B94 Q37666154-68F339A6-44BB-4EC9-AF7D-7827F5ACA5C7 Q37951958-050C0D9B-7747-4DD7-B51A-DC0209293FAF Q37953288-C0C531AA-62B6-4AA4-B254-6911BF0609FB Q37987023-53909261-B4BB-4DC7-8599-18EC74606834 Q38093581-3DC0E592-69F8-4737-BE27-A3C37B41BF88 Q38290759-7585DCA6-5E7D-4452-999C-7A17CE860C48 Q38359194-58D411B8-6CDC-4759-A2EC-EE4992FCD115 Q38624484-982FCD3F-A6FE-48CA-8072-2C264130E749 Q38672394-DA60E516-358D-46E9-8F1D-D0FB6CBD5CB8 Q39611314-1F7DD0F5-1730-4222-BC91-9B0C50DA3C68 Q41045121-CD1D4741-521F-4B77-A881-814C036B5E95 Q41818673-21007816-3BA2-4C96-A203-3CA50E5F21A0 Q41892915-B3FC9777-B3C9-4F1C-BBDC-B69D69E9B7F0 Q42120365-FDB14286-8167-49FE-841D-9B8231EFD493 Q42222872-0840EF1A-CB83-4187-844C-E808701B0CFA Q51325327-CB5DD552-EF95-44BB-A84C-B7DCEA7C9D27 Q55081064-1619D9FE-E006-4F27-B085-5F598CA17028 Q58693945-855736D5-FBE1-481A-B27A-65A6C9AB4C8C

P2860

Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin

http://www.wikidata.org/entity/Q28752238

description

2009 nî lūn-bûn

@nan

2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

Drosophila HtrA2 is dispensabl ...... INK1 independently from Parkin

@ast

Drosophila HtrA2 is dispensabl ...... INK1 independently from Parkin

@en

Drosophila HtrA2 is dispensabl ...... INK1 independently from Parkin

@nl

type

label

Drosophila HtrA2 is dispensabl ...... INK1 independently from Parkin

@ast

Drosophila HtrA2 is dispensabl ...... INK1 independently from Parkin

@en

Drosophila HtrA2 is dispensabl ...... INK1 independently from Parkin

@nl

prefLabel

Drosophila HtrA2 is dispensabl ...... INK1 independently from Parkin

@ast

Drosophila HtrA2 is dispensabl ...... INK1 independently from Parkin

@en

Drosophila HtrA2 is dispensabl ...... INK1 independently from Parkin

@nl

P1433

Q28752238-DCB7FFC0-0DEB-4C9D-B27C-FEFD51C233B7

P1476

Q28752238-94659FF2-24C6-4655-9931-4BB22F230A14

P2093

Q28752238-02FEF066-9877-41FA-AAE6-63A68577D7B3

Q28752238-34A26C34-842D-41EE-8AFD-3E6951DFFB2C

Q28752238-34B0DAEA-A4F4-4482-8219-94CFEDF8D002

Q28752238-3D2D26ED-2DED-4E30-AA3C-5E32B7AA75E0

Q28752238-87B881D2-19EB-469A-9DD0-A7027391836B

Q28752238-C91B53F1-E395-433C-9EB8-34A2AC76ADCE

Q28752238-CAC780E8-9E2E-43AB-888C-EDA2889CCBCB

Q28752238-CEFF52D5-B83B-47AF-AA01-76B2F888BA14

P2860

Q28752238-0C589A76-5A4D-4D21-B278-A2534B821CC4

Q28752238-0FA9CB11-B9C1-44CD-BF04-FBC62495C75B

Q28752238-2ABF620D-5C2E-409C-8E59-27E2E7B130D5

Q28752238-2D174094-1340-4058-9C11-0B853C53F83D

Q28752238-2E949742-65D0-4603-8D64-E45EADE6A2AF

Q28752238-415CDF21-3124-4D26-8CAF-2EF4981449FC

Q28752238-431E6A9A-6919-43CB-B35D-5254EDAABF21

Q28752238-443190D0-05BD-4631-BEE8-52F680F2C239

Q28752238-4479DE5C-CC74-4A19-9AB1-ACBC68823BC9

Q28752238-5491B2BB-F5E6-4561-BE91-C43707CD5548

P2888

Q28752238-78F40E86-2AE9-45AE-8E6B-D3B0F4A64C37

P304

Q28752238-5427DC3C-B6BC-45A9-8E73-AA80FFFB15AB

P31

Q28752238-CB3B4F98-C4DB-4EC6-895E-12F7FD74A00A

P356

Q28752238-6FC5065F-FD4B-4A85-B80F-7CD38417C02C

P407

Q28752238-839DB692-4F8E-49B8-BCDC-94C8AC6EEE9C

P433

Q28752238-DA146477-124E-45D0-92C3-17FDB8E8766A

P478

Q28752238-9B72C35F-7C8B-42CF-8D30-F23C932C77E6

P50

Q28752238-53E86664-9EF8-4DBD-B6D4-FC7E622DFDF4

P577

Q28752238-F336D2B8-EA4E-4311-A1CE-3C5A14BA434E

P5875

Q28752238-1BA4E5B6-32FB-4B43-A03A-3AE023F11BA1

P6179

Q28752238-95D8E56C-38E1-419A-8469-C206C8B91F14

P698

Q28752238-A56E4F7B-E17F-4941-B753-A1A6C311D6D1

P921

Q28752238-59F20587-DAD0-418E-8B66-FA8F64B0080A

Q28752238-EFEDDA79-82BF-415C-A52D-78A04623B334

P932

Q28752238-A84AF374-6126-4CF1-BCFF-9B606669EA2D

P356

P1433

Cell Death & Differentiation

P1476

Drosophila HtrA2 is dispensabl ...... INK1 independently from Parkin

@en

P2093

A J Whitworth

http://www.w3.org/2001/XMLSchema#string

H Plun-Favreau

http://www.w3.org/2001/XMLSchema#string

L M Martins

http://www.w3.org/2001/XMLSchema#string

L S Tain

http://www.w3.org/2001/XMLSchema#string

N Moisoi

http://www.w3.org/2001/XMLSchema#string

N Tapon

http://www.w3.org/2001/XMLSchema#string

R B Chowdhury

http://www.w3.org/2001/XMLSchema#string

R N Tao

http://www.w3.org/2001/XMLSchema#string

P2860

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis

Allosteric activation of DegS, a stress sensor PDZ protease

Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2

Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice

The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice

The HtrA Family of Proteases

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

P2888

P304

1118-25

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/CDD.2009.23

http://www.w3.org/2001/XMLSchema#string

P407

P433

8

http://www.w3.org/2001/XMLSchema#string

P478

16

http://www.w3.org/2001/XMLSchema#string

P50

Julian Downward

P577

2009-08-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

24197670

http://www.w3.org/2001/XMLSchema#string

P6179

1005199004

http://www.w3.org/2001/XMLSchema#string

P698

19282869

http://www.w3.org/2001/XMLSchema#string

P921

P932

2711053

http://www.w3.org/2001/XMLSchema#string