Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
about
Parkinson's disease: from monogenic forms to genetic susceptibility factorsGenetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation updateThe mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawalBiochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neuronsMutations in the GIGYF2 (TNRC15) gene at the PARK11 locus in familial Parkinson diseaseExclusion of PINK1 as candidate gene for the late-onset form of Parkinson's disease in two European populations.Mitochondrial dysfunction in Parkinson's diseaseRegulation of Cell Death by IAPs and Their AntagonistsThe yeast HtrA orthologue Ynm3 is a protease with chaperone activity that aids survival under heat stress.Mitochondrial protein quality control: the mechanisms guarding mitochondrial healthIdentification of TMEM230 mutations in familial Parkinson's diseaseThe protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathwayThe mitochondrial serine protease HtrA2/Omi: an overviewCell biology. Metabolic control of cell deathOmi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's diseaseReduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from ParkinParkinson's Disease and Cognitive ImpairmentRegulation of parkin and PINK1 by neddylation.Genetic susceptibility in Parkinson's diseaseLack of replication of association between GIGYF2 variants and Parkinson disease.Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls.Hyperexcitable substantia nigra dopamine neurons in PINK1- and HtrA2/Omi-deficient mice.Mitochondrial DNA and primary mitochondrial dysfunction in Parkinson's disease.Novel mitochondrial substrates of omi indicate a new regulatory role in neurodegenerative disorders.Mitochondrial quality control: insights on how Parkinson's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis.Arabidopsis AtPARK13, which confers thermotolerance, targets misfolded proteins.Caenorhabditis elegans: a model to investigate oxidative stress and metal dyshomeostasis in Parkinson's diseaseCandidate genes for chromosomes 6 and 10 quantitative trait loci for age-related retinal degeneration in mice.Dynamic changes of the phosphoproteome in postmortem mouse brains.The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicityUnravelling the role of defective genes.Overexpression of parkin ameliorates dopaminergic neurodegeneration induced by 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors.Resolving candidate genes of mouse skeletal muscle QTL via RNA-Seq and expression network analysesThe genetic background of Parkinson's disease: current progress and future prospects.The genetics of Parkinson disease.Mitochondrial morphogenesis, distribution, and Parkinson disease: insights from PINK1
P2860
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P2860
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
description
2005 nî lūn-bûn
@nan
2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
@ast
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
@en
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
@nl
type
label
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
@ast
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
@en
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
@nl
prefLabel
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
@ast
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
@en
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
@nl
P2093
P50
P3181
P356
P1476
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
@en
P2093
Antje Bornemann
Frank P Marx
Karsten M Strauss
L Miguel Martins
Sabine Kautzmann
Thomas Müller
Zbginiew Wszolek
P304
P356
10.1093/HMG/DDI215
P407
P50
P577
2005-08-01T00:00:00Z