LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin
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Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2 to LRP6 phosphorylationStructural and functional characterization of the Wnt inhibitor APC membrane recruitment 1 (Amer1)Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activationDirect inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signalingWnt/beta-catenin signaling and small molecule inhibitorsWnt/beta-catenin signaling: components, mechanisms, and diseasesShared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members.Wnt signaling induces epithelial differentiation during cutaneous wound healingKeeping Wnt signalosome in check by vesicular trafficToggling a conformational switch in Wnt/β-catenin signaling: regulation of Axin phosphorylation. The phosphorylation state of Axin controls its scaffold function in two Wnt pathway protein complexesCurrent Understanding on EGFR and Wnt/β-Catenin Signaling in Glioma and Their Possible CrosstalkPyrvinium, a potent small molecule Wnt inhibitor, promotes wound repair and post-MI cardiac remodelingIdentification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signalingWnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodiesSmall molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancerIdentification of targets of the Wnt pathway destruction complex in addition to beta-catenin.GSK-3: Functional Insights from Cell Biology and Animal Models.Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6.Mitochondrial uncoupler exerts a synthetic lethal effect against β-catenin mutant tumor cellsDifferential modulation of TCF/LEF-1 activity by the soluble LRP6-ICD.GSK3: a multifaceted kinase in Wnt signaling.Reconstitution Of β-catenin degradation in Xenopus egg extract.Screening for small molecule inhibitors of embryonic pathways: sometimes you gotta crack a few eggs.Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes.Updating the Wnt pathways.Mitogen-activated protein kinases promote WNT/beta-catenin signaling via phosphorylation of LRP6.Tyrosine phosphorylation of LRP6 by Src and Fer inhibits Wnt/β-catenin signalling.Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity.Rad6B acts downstream of Wnt signaling to stabilize β-catenin: Implications for a novel Wnt/β-catenin target.Nuclear signaling from cadherin adhesion complexesSmall-molecule high-throughput screening utilizing Xenopus egg extract.Water extract of brewers' rice induces apoptosis in human colorectal cancer cells via activation of caspase-3 and caspase-8 and downregulates the Wnt/β-catenin downstream signaling pathway in brewers' rice-treated rats with azoxymethane-induced coloAdenomatous polyposis coli (APC) regulates multiple signaling pathways by enhancing glycogen synthase kinase-3 (GSK-3) activity.Low density lipoprotein (LDL) receptor-related protein 6 (LRP6) regulates body fat and glucose homeostasis by modulating nutrient sensing pathways and mitochondrial energy expenditureCross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5).Concurrent transient activation of Wnt/β-catenin pathway prevents radiation damage to salivary glands.Endocytic control of growth factor signalling: multivesicular bodies as signalling organellesPhosphorylations of Serines 21/9 in Glycogen Synthase Kinase 3α/β Are Not Required for Cell Lineage Commitment or WNT Signaling in the Normal Mouse IntestineDual Roles for Membrane Association of Drosophila Axin in Wnt Signaling.Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling
P2860
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P2860
LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
LRP6 transduces a canonical Wn ...... hosphorylation of beta-catenin
@ast
LRP6 transduces a canonical Wn ...... hosphorylation of beta-catenin
@en
LRP6 transduces a canonical Wn ...... hosphorylation of beta-catenin
@nl
type
label
LRP6 transduces a canonical Wn ...... hosphorylation of beta-catenin
@ast
LRP6 transduces a canonical Wn ...... hosphorylation of beta-catenin
@en
LRP6 transduces a canonical Wn ...... hosphorylation of beta-catenin
@nl
prefLabel
LRP6 transduces a canonical Wn ...... hosphorylation of beta-catenin
@ast
LRP6 transduces a canonical Wn ...... hosphorylation of beta-catenin
@en
LRP6 transduces a canonical Wn ...... hosphorylation of beta-catenin
@nl
P2093
P2860
P3181
P356
P1476
LRP6 transduces a canonical Wn ...... hosphorylation of beta-catenin
@en
P2093
Christopher S Cselenyi
Curtis A Thorne
Emilios Tahinci
Kristin K Jernigan
Laura A Lee
P2860
P304
P3181
P356
10.1073/PNAS.0803025105
P407
P577
2008-06-10T00:00:00Z