Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases
about
SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domainsSuper-Enhancer-Driven Transcriptional Dependencies in Cancer.CDK8/19 Mediator kinases potentiate induction of transcription by NFκB.Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.The complex structure and function of Mediator.CDK8: a new breast cancer target.CDK8 Kinase Activity Promotes Glycolysis.Structure-based drug design: aiming for a perfect fit.CDK8/19 inhibition induces premature G1/S transition and ATR-dependent cell death in prostate cancer cells.The mediator complex in genomic and non-genomic signaling in cancer.
P2860
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P2860
Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases
description
2016 nî lūn-bûn
@nan
2016 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Assessing the mechanism and th ...... lex-associated protein kinases
@ast
Assessing the mechanism and th ...... lex-associated protein kinases
@en
type
label
Assessing the mechanism and th ...... lex-associated protein kinases
@ast
Assessing the mechanism and th ...... lex-associated protein kinases
@en
prefLabel
Assessing the mechanism and th ...... lex-associated protein kinases
@ast
Assessing the mechanism and th ...... lex-associated protein kinases
@en
P2093
P2860
P50
P356
P1433
P1476
Assessing the mechanism and th ...... lex-associated protein kinases
@en
P2093
Alexis De Haven Brandon
Andree Blaukat
Aurélie Mallinger
Christina Esdar
Dirk Wienke
Felix Rohdich
Florence Raynaud
Kai Schiemann
P2860
P356
10.7554/ELIFE.20722
P407
P577
2016-12-09T00:00:00Z