Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
about
Molecular topology as novel strategy for discovery of drugs with aβ lowering and anti-aggregation dual activities for Alzheimer's diseaseDocosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARγ-mediated mechanisms in Alzheimer's disease modelsTreatment of Alzheimer's disease with anti-homocysteic acid antibody in 3xTg-AD male miceTransthyretin and the brain re-visited: is neuronal synthesis of transthyretin protective in Alzheimer's disease?Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomersGene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brainCharacterizing affinity epitopes between prion protein and β-amyloid using an epitope mapping immunoassayProgressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteinsAmyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastinInhibition of calpain prevents NMDA-induced cell death and beta-amyloid-induced synaptic dysfunction in hippocampal slice culturesApolipoprotein E receptors in the nervous systemS-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by beta-amyloid peptideAmyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networksSynthetic amyloid-beta oligomers impair long-term memory independently of cellular prion proteinProtein phosphatases and Alzheimer's diseaseMechanisms of synapse and dendrite maintenance and their disruption in psychiatric and neurodegenerative disordersRelationships between expression of apolipoprotein E and beta-amyloid precursor protein are altered in proximity to Alzheimer beta-amyloid plaques: potential explanations from cell culture studiesDays to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomersAmyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memorySoluble oligomers of the amyloid beta-protein impair synaptic plasticity and behaviorProtein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseasesReelin signaling antagonizes beta-amyloid at the synapseReversal of long-term dendritic spine alterations in Alzheimer disease modelsSignaling effect of amyloid-beta(42) on the processing of AbetaPPSynapses and Alzheimer's diseaseAmyloidosis in Retinal Neurodegenerative DiseasesThe Emergence of NMDA Receptor Metabotropic Function: Insights from ImagingThe Rationale for Insulin Therapy in Alzheimer's DiseaseNon-ionotropic signaling by the NMDA receptor: controversy and opportunityCalcium-Sensing Receptors of Human Neural Cells Play Crucial Roles in Alzheimer's DiseaseAmyloid-β-Induced Dysregulation of AMPA Receptor TraffickingRegulation of the Postsynaptic Compartment of Excitatory Synapses by the Actin Cytoskeleton in Health and Its Disruption in DiseaseEmerging Link between Alzheimer's Disease and Homeostatic Synaptic PlasticityDiabetes Mellitus Induces Alzheimer's Disease Pathology: Histopathological Evidence from Animal ModelsMetals and Neuronal Metal Binding Proteins Implicated in Alzheimer's DiseaseDysfunction of NMDA receptors in Alzheimer's diseaseAmyloid-β Receptors: The Good, the Bad, and the Prion ProteinTau Oligomers: The Toxic Player at Synapses in Alzheimer's DiseaseGenetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse modelGene expression parallels synaptic excitability and plasticity changes in Alzheimer's disease
P2860
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P2860
Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
description
2007 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
im März 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
wetenschappelijk artikel (gepubliceerd op 2007/03/14)
@nl
наукова стаття, опублікована в березні 2007
@uk
مقالة علمية (نشرت في 14-3-2007)
@ar
name
Natural oligomers of the Alzhe ...... or-dependent signaling pathway
@ast
Natural oligomers of the Alzhe ...... or-dependent signaling pathway
@en
type
label
Natural oligomers of the Alzhe ...... or-dependent signaling pathway
@ast
Natural oligomers of the Alzhe ...... or-dependent signaling pathway
@en
prefLabel
Natural oligomers of the Alzhe ...... or-dependent signaling pathway
@ast
Natural oligomers of the Alzhe ...... or-dependent signaling pathway
@en
P2093
P921
P3181
P1476
Natural oligomers of the Alzhe ...... or-dependent signaling pathway
@en
P2093
Bernardo L Sabatini
Dennis J Selkoe
Dominic M Walsh
Ganesh M Shankar
Matthew Townsend
P304
P3181
P356
10.1523/JNEUROSCI.4970-06.2007
P407
P577
2007-03-14T00:00:00Z