SNX27 mediates PDZ-directed sorting from endosomes to the plasma membraneGlobal landscape of HIV-human protein complexesDesign, activity, and structure of a highly specific artificial endonucleaseSymmetry recognizing asymmetry: analysis of the interactions between the C-type lectin-like immunoreceptor NKG2D and MHC class I-like ligandsConvergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130A New Twist in TCR Diversity Revealed by a Forbidden αβ TCRA Correspondence Between Solution-State Dynamics of an Individual Protein and the Sequence and Conformational Diversity of its FamilyA Mechanism for Tunable Autoinhibition in the Structure of a Human Ca2+/Calmodulin- Dependent Kinase II HoloenzymeControl of protein signaling using a computationally designed GTPase/GEF orthogonal pairProtein-protein docking predictions for the CAPRI experimentSub-angstrom accuracy in protein loop reconstruction by robotics-inspired conformational samplingOutcome of a workshop on applications of protein models in biomedical researchDetermination of ubiquitin fitness landscapes under different chemical stresses in a classroom settingDesign of Light-Controlled Protein Conformations and FunctionsCoupling Protein Side-Chain and Backbone Flexibility Improves the Re-design of Protein-Ligand SpecificityA Web Resource for Standardized Benchmark Datasets, Metrics, and Rosetta Protocols for Macromolecular Modeling and DesignCombined covalent-electrostatic model of hydrogen bonding improves structure prediction with RosettaQuantification of the transferability of a designed protein specificity switch reveals extensive epistasis in molecular recognitionROSETTA3: an object-oriented software suite for the simulation and design of macromoleculesReprogramming an ATP-driven protein machine into a light-gated nanocageMulti-constraint computational design suggests that native sequences of germline antibody H3 loops are nearly optimal for conformational flexibilityAmino-acid site variability among natural and designed proteinsComputational protein design quantifies structural constraints on amino acid covariationDesign of a photoswitchable cadherinFlexible backbone sampling methods to model and design protein alternative conformationsScientific benchmarks for guiding macromolecular energy function improvementServerification of molecular modeling applications: the Rosetta Online Server that Includes Everyone (ROSIE)Improvements to robotics-inspired conformational sampling in rosettaA simple model of backbone flexibility improves modeling of side-chain conformational variabilityPrediction of mutational tolerance in HIV-1 protease and reverse transcriptase using flexible backbone protein designAssessment of flexible backbone protein design methods for sequence library prediction in the therapeutic antibody Herceptin-HER2 interfaceConstruction of a genetic multiplexer to toggle between chemosensory pathways in Escherichia coliPredicting the tolerated sequences for proteins and protein interfaces using RosettaBackrub flexible backbone designRosettaBackrub--a web server for flexible backbone protein structure modeling and designEngineered protein connectivity to actin mimics PDZ-dependent recycling of G protein-coupled receptors but not its regulation by HrsBackrub-like backbone simulation recapitulates natural protein conformational variability and improves mutant side-chain predictionDifferences in flexibility underlie functional differences in the Ras activators son of sevenless and Ras guanine nucleotide releasing factor 1Complex topology rather than complex membership is a determinant of protein dosage sensitivityStructural mapping of protein interactions reveals differences in evolutionary pressures correlated to mRNA level and protein abundanceDesign of multi-specificity in protein interfaces
P50
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P50
description
computational biologist
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wetenschapper
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Tanja Kortemme
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Tanja Kortemme
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Tanja Kortemme
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Tanja Kortemme
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Tanja Kortemme
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Tanja Kortemme
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Tanja Kortemme
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Tanja Kortemme
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Tanja Kortemme
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Tanja Kortemme
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Tanja Kortemme
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Tanja Kortemme
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Tanja Kortemme
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Tanja Kortemme
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Tanja Kortemme
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Tanja Kortemme
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Tanja Kortemme
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Tanja Kortemme
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Tanja Kortemme
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Tanja Kortemme
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prefLabel
Tanja Kortemme
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Tanja Kortemme
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Tanja Kortemme
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Tanja Kortemme
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Tanja Kortemme
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Tanja Kortemme
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Tanja Kortemme
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Tanja Kortemme
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Tanja Kortemme
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Tanja Kortemme
@kl
P21
P2381
P31
P496
0000-0002-8494-680X