ATM and related protein kinases: safeguarding genome integrity
about
Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patientATM promotes the obligate XY crossover and both crossover control and chromosome axis integrity on autosomesCollaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signalingTel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexesWild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repairFunctional interaction of BRCA1/ATM-associated BAAT1 with the DNA-PK catalytic subunitDNA-damage-responsive acetylation of pRb regulates binding to E2F-1DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilizationATM activation by ionizing radiation requires BRCA1-associated BAAT1ATM-dependent phosphorylation of ATF2 is required for the DNA damage responseIncreased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanismHuman PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiationRAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sitesATMIN defines an NBS1-independent pathway of ATM signallingRNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells.How cells switch HIPK2 on and offRAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylationNEK11 regulates CDC25A degradation and the IR-induced G2/M checkpointInteraction between human MCM7 and Rad17 proteins is required for replication checkpoint signalingA novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stabilityCdc5L interacts with ATR and is required for the S-phase cell-cycle checkpointRegulation of TIP60 by ATF2 modulates ATM activationSMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decayBBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage responsePhospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damagePPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpointsInvolvement of human MOF in ATM functionSurveillance of different recombination defects in mouse spermatocytes yields distinct responses despite elimination at an identical developmental stage.Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stressThe transcriptional histone acetyltransferase cofactor TRRAP associates with the MRN repair complex and plays a role in DNA double-strand break repairDNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2ADeficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutantsFunctional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppressionArtemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint responseHuman Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpointMdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retentionRereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpointATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damageDirect regulation of CREB transcriptional activity by ATM in response to genotoxic stress
P2860
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P2860
ATM and related protein kinases: safeguarding genome integrity
description
2003 nî lūn-bûn
@nan
2003 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մարտին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
ATM and related protein kinases: safeguarding genome integrity
@ast
ATM and related protein kinases: safeguarding genome integrity
@en
type
label
ATM and related protein kinases: safeguarding genome integrity
@ast
ATM and related protein kinases: safeguarding genome integrity
@en
prefLabel
ATM and related protein kinases: safeguarding genome integrity
@ast
ATM and related protein kinases: safeguarding genome integrity
@en
P3181
P356
P1476
ATM and related protein kinases: safeguarding genome integrity
@en
P2093
P2888
P304
P3181
P356
10.1038/NRC1011
P407
P577
2003-03-01T00:00:00Z
P5875
P6179
1026716666