The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
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Menopause, obesity and inflammation: interactive risk factors for Alzheimer's diseaseGalactic cosmic radiation leads to cognitive impairment and increased aβ plaque accumulation in a mouse model of Alzheimer's diseaseThe Alzheimer's amyloid-degrading peptidase, neprilysin: can we control it?Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study.Alzheimer mechanisms and therapeutic strategiesAmyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastinGpr3 stimulates Aβ production via interactions with APP and β-arrestin2Clec4g (LSECtin) interacts with BACE1 and suppresses Aβ generationClathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer's brainsBrain investigation and brain conceptualizationTemperature and toxic Tau in Alzheimer's disease: new insightsOne for All? Hitting Multiple Alzheimer's Disease Targets with One DrugChronic Stress and Glucocorticoids: From Neuronal Plasticity to NeurodegenerationThe Unfolded Protein Response and the Role of Protein Disulfide Isomerase in NeurodegenerationConnectivity of Pathology: The Olfactory System as a Model for Network-Driven Mechanisms of Alzheimer's Disease PathogenesisTau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic ParaplegiaProteomics in Traditional Chinese Medicine with an Emphasis on Alzheimer's Diseaseβ-Amyloid: the key peptide in the pathogenesis of Alzheimer's diseaseVitamin D and Alzheimer's Disease: Neurocognition to TherapeuticsFluid Biomarkers in Clinical Trials of Alzheimer's Disease TherapeuticsAlzheimer's in 3D culture: challenges and perspectivesTargeting the proper amyloid-beta neuronal toxins: a path forward for Alzheimer's disease immunotherapeuticsDiverse molecular targets for therapeutic strategies in Alzheimer's diseaseTransient dynamics of Aβ contribute to toxicity in Alzheimer's diseasePlatelets and Alzheimer's disease: Potential of APP as a biomarkerAmylin at the interface between metabolic and neurodegenerative disordersAmyloid β precursor protein as a molecular target for amyloid β--induced neuronal degeneration in Alzheimer's diseaseThe end of Alzheimer's disease--from biochemical pharmacology to ecopsychosociology: a personal perspectiveSynaptic dysfunction and septin protein family members in neurodegenerative diseasesAlzheimer's disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression.The Amyloid Precursor Protein Controls PIKfyve FunctionEPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaquesTargeting the prodromal stage of Alzheimer's disease: bioenergetic and mitochondrial opportunitiesCellular model of neuronal atrophy induced by DYNC1I1 deficiency reveals protective roles of RAS-RAF-MEK signaling.Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ ReductionMonoaminergic and Histaminergic Strategies and Treatments in Brain DiseasesNeuropsychiatric Disturbances in Alzheimer's Disease: What Have We Learned from Neuropathological Studies?From ARB to ARNI in Cardiovascular ControlRisk factor SORL1: from genetic association to functional validation in Alzheimer's disease3D culture models of Alzheimer's disease: a road map to a "cure-in-a-dish"
P2860
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P2860
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The amyloid cascade hypothesis ...... he development of therapeutics
@ast
The amyloid cascade hypothesis ...... he development of therapeutics
@en
type
label
The amyloid cascade hypothesis ...... he development of therapeutics
@ast
The amyloid cascade hypothesis ...... he development of therapeutics
@en
prefLabel
The amyloid cascade hypothesis ...... he development of therapeutics
@ast
The amyloid cascade hypothesis ...... he development of therapeutics
@en
P2093
P3181
P356
P1476
The amyloid cascade hypothesis ...... he development of therapeutics
@en
P2093
De Strooper B
P2888
P304
P3181
P356
10.1038/NRD3505
P407
P577
2011-08-19T00:00:00Z
P6179
1009624842