Protein kinases--the major drug targets of the twenty-first century?
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Structural and functional diversity of the microbial kinomeGenome of the human hookworm Necator americanusDynamic profiling of the post-translational modifications and interaction partners of epidermal growth factor receptor signaling after stimulation by epidermal growth factor using Extended Range Proteomic Analysis (ERPA)Conformational coupling across the plasma membrane in activation of the EGF receptorAllosteric activation of the protein kinase PDK1 with low molecular weight compoundsAn Id-like molecule, HHM, is a synexpression group-restricted regulator of TGF-beta signallingAn evolutionary proteomics approach identifies substrates of the cAMP-dependent protein kinaseCharacterization of the reversible phosphorylation and activation of ERK8Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocyclesA unified approach to the important protein kinase inhibitor balanol and a proposed analogueThe chemical biology of protein phosphorylationCyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitisOn the origins of enzyme inhibitor selectivity and promiscuity: a case study of protein kinase binding to staurosporineSelectivity of docking sites in MAPK kinasesA conserved protonation-dependent switch controls drug binding in the Abl kinaseTargeting protein serine/threonine phosphatases for drug developmentProtein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryoteHigh-throughput kinase assays with protein substrates using fluorescent polymer superquenchingCombining RNA interference and kinase inhibitors against cell signalling components involved in cancer.Resistance to receptor tyrosine kinase inhibitors in solid tumors: can we improve the cancer fighting strategy by blocking autophagy?Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson's DiseaseFrom the primordial soup to self-driving cars: standards and their role in natural and technological innovationMelanoma: oncogenic drivers and the immune systemCounteracting Protein Kinase Activity in the Heart: The Multiple Roles of Protein PhosphatasesRecent findings and technological advances in phosphoproteomics for cells and tissuesElectrochemistry of nonconjugated proteins and glycoproteins. Toward sensors for biomedicine and glycomicsTen things you should know about protein kinases: IUPHAR Review 14The dynamic nature of the kinomeTargeting cancer with kinase inhibitorsPINK1 and Parkin – mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's diseaseStructure and mechanism of non-histone protein acetyltransferase enzymesBivalent inhibitors of protein kinasesDrugs for allosteric sites on receptorsThe two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatmentScreening marine resources to find novel chemical inhibitors of disease-relevant protein kinasesActivated Ras as a Therapeutic Target: Constraints on Directly Targeting Ras Isoforms and Wild-Type versus Mutated ProteinsUsing existing drugs as leads for broad spectrum anthelmintics targeting protein kinasesInhibition of protein kinase CK2 by anthraquinone-related compounds. A structural insightAlternative binding modes of an inhibitor to two different kinasesA systematic interaction map of validated kinase inhibitors with Ser/Thr kinases
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P2860
Protein kinases--the major drug targets of the twenty-first century?
description
2002 nî lūn-bûn
@nan
2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Protein kinases--the major drug targets of the twenty-first century?
@ast
Protein kinases--the major drug targets of the twenty-first century?
@en
type
label
Protein kinases--the major drug targets of the twenty-first century?
@ast
Protein kinases--the major drug targets of the twenty-first century?
@en
prefLabel
Protein kinases--the major drug targets of the twenty-first century?
@ast
Protein kinases--the major drug targets of the twenty-first century?
@en
P2860
P3181
P356
P1476
Protein kinases--the major drug targets of the twenty-first century?
@en
P2093
P2860
P2888
P304
P3181
P356
10.1038/NRD773
P407
P577
2002-04-01T00:00:00Z
P5875
P6179
1011169875