Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)
about
Reduced serotonin reuptake transporter (SERT) function causes insulin resistance and hepatic steatosis independent of food intakeMain roads to melanomaThe interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocationRegulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTPA method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domainSystematic Analysis Reveals Elongation Factor 2 and α-Enolase as Novel Interaction Partners of AKT253BP2S, interacting with insulin receptor substrates, modulates insulin signalingKinetic mechanism of AKT/PKB enzyme familyC2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane.Identification of a proline-rich Akt substrate as a 14-3-3 binding partnerIncreased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinaseEssential role of PDK1 in regulating cell size and development in miceDe novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromesThe kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAsNesfatin-1 action in the brain increases insulin sensitivity through Akt/AMPK/TORC2 pathway in diet-induced insulin resistanceThe PI3K pathway as drug target in human cancermTOR signaling: at the crossroads of plasticity, memory and diseaseNuclear Akt interacts with B23/NPM and protects it from proteolytic cleavage, enhancing cell survivalIdentification of MUP1 as a regulator for glucose and lipid metabolism in miceSevere diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB betaSkeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficienciesErythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/AKT signaling pathwayTranscriptome Analysis Reveals a Signature Profile for Tick-Borne Flavivirus Persistence in HEK 293T CellsInfluence of Acute and Chronic Exercise on Glucose UptakeMetabolic functions of FABPs--mechanisms and therapeutic implicationsMolecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and β-Cell DysfunctionInsulin receptor signaling in normal and insulin-resistant statesDiverse mechanisms of AKT pathway activation in human malignancyPI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasmsmTOR-dependent cell survival mechanismsRegulation of Akt signaling by sirtuins: its implication in cardiac hypertrophy and agingMolecular basis of physiological heart growth: fundamental concepts and new playersControl of muscle mitochondria by insulin entails activation of Akt2-mtNOS pathway: implications for the metabolic syndromeTwo membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signalingWortmannin reduces insulin signaling and death in seizure-prone Pcmt1-/- miceMetabolic Effects of CX3CR1 Deficiency in Diet-Induced Obese MiceMutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin ResistanceBreast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signalingHyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes
P2860
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P2860
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Insulin resistance and a diabe ...... protein kinase Akt2 (PKB beta)
@ast
Insulin resistance and a diabe ...... protein kinase Akt2 (PKB beta)
@en
type
label
Insulin resistance and a diabe ...... protein kinase Akt2 (PKB beta)
@ast
Insulin resistance and a diabe ...... protein kinase Akt2 (PKB beta)
@en
prefLabel
Insulin resistance and a diabe ...... protein kinase Akt2 (PKB beta)
@ast
Insulin resistance and a diabe ...... protein kinase Akt2 (PKB beta)
@en
P2093
P50
P3181
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P1476
Insulin resistance and a diabe ...... protein kinase Akt2 (PKB beta)
@en
P2093
E B Crenshaw
J L Thorvaldsen
K H Kaestner
M S Bartolomei
P304
P3181
P356
10.1126/SCIENCE.292.5522.1728
P407
P577
2001-06-01T00:00:00Z