Ribosomal protein S6 kinase 1 signaling regulates mammalian life span - Wikidata - wikimedia - TriplyDB

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

http://www.wikidata.org/entity/Q29615975

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Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease Age-associated bidirectional modulation of gene expression in single identified R15 neuron of Aplysia SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling S6K1 plays a critical role in early adipocyte differentiation Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity Extending healthy life span--from yeast to humans Lessons on longevity from budding yeast mTOR is a key modulator of ageing and age-related disease An emerging role for TOR signaling in mammalian tissue and stem cell physiology Single-gene mutations and healthy ageing in mammals Aging as an event of proteostasis collapse mTOR: from growth signal integration to cancer, diabetes and ageing Finding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging Molecules The Role of Autophagy, Mitophagy and Lysosomal Functions in Modulating Bioenergetics and Survival in the Context of Redox and Proteotoxic Damage: Implications for Neurodegenerative Diseases Inhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and Beyond Live strong and prosper: the importance of skeletal muscle strength for healthy ageing The role of the ribosome in the regulation of longevity and lifespan extension Alpha-Ketoglutarate: Physiological Functions and Applications Biochemical Genetic Pathways that Modulate Aging in Multiple Species The neurology of mTOR Healthy aging: is smaller better? - a mini-review The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity Axis of ageing: telomeres, p53 and mitochondria Rapalogs in cancer prevention: anti-aging or anticancer?Genetics and epigenetics of aging and longevity Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin Molecular mechanism of extrinsic factors affecting anti-aging of stem cells Modelling age-related metabolic disorders in the mouse DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans The circadian clock coordinates ribosome biogenesis A Drosophila model of high sugar diet-induced cardiomyopathy Manipulation of behavioral decline in Caenorhabditis elegans with the Rag GTPase raga-1 Autophagy and cardiovascular aging: lesson learned from rapamycin.Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation.Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disorders Gender, aging and longevity in humans: an update of an intriguing/neglected scenario paving the way to a gender-specific medicine Cellular and molecular biology of aging endothelial cells

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P2860

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

http://www.wikidata.org/entity/Q29615975

description

2009 nî lūn-bûn

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2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

@zh-hk

2009年論文

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2009年論文

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2009年论文

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name

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

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Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

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type

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Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

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Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

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Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

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Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

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Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

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Al-Qassab H

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Batterham RL

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Carling D

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Carmignac D

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Choudhury AI

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Claret M

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Gems D

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Irvine E

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Kozma SC

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Lingard SJ

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P2860

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

AMPK and PPARdelta agonists are exercise mimetics

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

Temporal linkage between the phenotypic and genomic responses to caloric restriction

Biomarkers of aging: prediction of longevity by using age-sensitive T-cell subset determinations in a middle-aged, genetically heterogeneous mouse population.

Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans.

Functionally significant insulin-like growth factor I receptor mutations in centenarians

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