The dynamic energy landscape of dihydrofolate reductase catalysis
about
A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysisDifferential substrate specificity and kinetic behavior of Escherichia coli YfdW and Oxalobacter formigenes formyl coenzyme A transferaseScale-free flow of life: on the biology, economics, and physics of the cellBiophysical and computational methods to analyze amino acid interaction networks in proteinsInsights into Protein-Ligand Interactions: Mechanisms, Models, and MethodsDirect and Propagated Effects of Small Molecules on Protein-Protein Interaction NetworksConformational selection in protein binding and functionComputer aided enzyme design and catalytic conceptsSynergistic applications of MD and NMR for the study of biological systemsAllosteric activation transitions in enzymes and biomolecular motors: insights from atomistic and coarse-grained simulationsEvolutionarily conserved linkage between enzyme fold, flexibility, and catalysisAllosteric communication in myosin V: from small conformational changes to large directed movementsDiscovering conformational sub-states relevant to protein functionStructure in an extreme environment: NMR at high saltSolution Structure of Inhibitor-Free Human Metalloelastase (MMP-12) Indicates an Internal Conformational AdjustmentStructural identification of the pathway of long-range communication in an allosteric enzymeA Coupled Equilibrium Shift Mechanism in Calmodulin-Mediated Signal TransductionRecognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solutionX-ray Crystallographic and Solution State Nuclear Magnetic Resonance Spectroscopic Investigations of NADP + Binding to Ferredoxin NADP Reductase from Pseudomonas aeruginosa † , ‡A Correspondence Between Solution-State Dynamics of an Individual Protein and the Sequence and Conformational Diversity of its FamilyPressure-Dependent Structure Changes in Barnase on Ligand Binding Reveal Intermediate Rate FluctuationsHidden alternative structures of proline isomerase essential for catalysisConformational sampling, catalysis, and evolution of the bacterial phosphotriesteraseImportance of the gating segment in the substrate-recognition loop of pyranose 2-oxidaseConformational selection in the molten globule state of the nuclear coactivator binding domain of CBPNMR Structures of Apo L. casei Dihydrofolate Reductase and Its Complexes with Trimethoprim and NADPH: Contributions to Positive Cooperative Binding from Ligand-Induced Refolding, Conformational Changes, and Interligand Hydrophobic InteractionsSolution structure of a minor and transiently formed state of a T4 lysozyme mutantConformational Changes in Orotidine 5′-Monophosphate Decarboxylase: A Structure-Based Explanation for How the 5′-Phosphate Group Activates the EnzymePUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosisEvidence for dynamics in proteins as a mechanism for ligand dissociationFunctional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humansSequence Determinants of a Specific Inactive Protein Kinase ConformationAutomated identification of functional dynamic contact networks from X-ray crystallographyDivergent evolution of protein conformational dynamics in dihydrofolate reductase.Essential role of conformational selection in ligand bindingDetermination of structural fluctuations of proteins from structure-based calculations of residual dipolar couplingsIntegrated description of protein dynamics from room-temperature X-ray crystallography and NMRLigand binding and self-association cooperativity of β-lactoglobulinCrystal Cryocooling Distorts Conformational Heterogeneity in a Model Michaelis Complex of DHFRExploring the role of conformational heterogeneity in cis-autoproteolytic activation of ThnT.
P2860
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P2860
The dynamic energy landscape of dihydrofolate reductase catalysis
description
2006 nî lūn-bûn
@nan
2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
The dynamic energy landscape of dihydrofolate reductase catalysis
@ast
The dynamic energy landscape of dihydrofolate reductase catalysis
@en
type
label
The dynamic energy landscape of dihydrofolate reductase catalysis
@ast
The dynamic energy landscape of dihydrofolate reductase catalysis
@en
prefLabel
The dynamic energy landscape of dihydrofolate reductase catalysis
@ast
The dynamic energy landscape of dihydrofolate reductase catalysis
@en
P2093
P3181
P356
P1433
P1476
The dynamic energy landscape of dihydrofolate reductase catalysis
@en
P2093
Dan McElheny
David D Boehr
Peter E Wright
P304
P3181
P356
10.1126/SCIENCE.1130258
P407
P577
2006-09-01T00:00:00Z