PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity - Wikidata - wikimedia - TriplyDB

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

http://www.wikidata.org/entity/Q29617292

about

Short mitochondrial ARF triggers Parkin/PINK1-dependent mitophagy Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402 Multiple Roles of the Small GTPase Rab7 Mitochondrial dysfunction in Parkinson's disease The recognition of ubiquitinated proteins by the proteasome Ubiquitin modifications Myosins, Actin and Autophagy The business of deubiquitination - location, location, location Ubiquitin phosphorylation in Parkinson's disease: Implications for pathogenesis and treatment Mitochondrial Quality Control and Muscle Mass Maintenance Parkin Regulation and Neurodegenerative Disorders Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy A Mechanistic Review of Mitophagy and Its Role in Protection against Alcoholic Liver Disease The different facets of organelle interplay-an overview of organelle interactions Autophagy signal transduction by ATG proteins: from hierarchies to networks Mitochondrial and Ubiquitin Proteasome System Dysfunction in Ageing and Disease: Two Sides of the Same Coin?Expanding the ubiquitin code through post-translational modification Regulating the Regulators: Recent Revelations in the Control of E3 Ubiquitin Ligases Quantifying ubiquitin signaling The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications PINK1 and Parkin – mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease Mending a broken heart: the role of mitophagy in cardioprotection Parkin structure and function Pathologic and therapeutic implications for the cell biology of parkin Mitophagy and the mitochondrial unfolded protein response in neurodegeneration and bacterial infection Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1.Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering Phosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase Parkin Activation of the E3 ubiquitin ligase Parkin.Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease The critical roles of mitophagy in cerebral ischemia Mechanism and disease association of E2-conjugating enzymes: lessons from UBE2T and UBE2L3 Mitochondrial Quality Control in Cardiac Diseases Sending Out an SOS: Mitochondria as a Signaling Hub Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance LRRK2 at the interface of autophagosomes, endosomes and lysosomes Targeting Pink1-Parkin-mediated mitophagy for treating liver injury Mitochondrial protein quality control: the mechanisms guarding mitochondrial health

P2860

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P2860

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

http://www.wikidata.org/entity/Q29617292

description

2014 nî lūn-bûn

@nan

2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

@ast

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

@en

type

label

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

@ast

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

@en

prefLabel

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

@ast

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

@en

P1433

Q29617292-BB4456E3-061F-4D0D-BC73-FAB4DFE72DBE

P1476

Q29617292-B5F9A9B2-72B4-4A44-ACE1-520388A9B96F

P2093

Q29617292-0157B715-7458-48EB-88A4-9D1CB3BD9259

Q29617292-2809571E-F1A9-4181-A45C-0E8248D0E340

Q29617292-3A4631DA-337F-40BD-9F55-047F2421538F

Q29617292-47018479-CF36-4B70-A701-EEAFBD6630D5

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P2860

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Q29617292-22AE0168-86BA-4610-834F-30944DC05272

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P356

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P407

Q29617292-B1D1A18F-177F-4356-8F26-C3B4B210A8C6

P433

Q29617292-A71210B0-34C9-4D92-9F2A-55DF1726C464

P478

Q29617292-C79523A5-D5A6-41BC-B38E-217C498EFEC8

P50

Q29617292-D9B18EFE-7974-4D47-9170-3E0194DCD970

P577

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P921

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P932

Q29617292-7A4B2723-CE14-45B9-AC88-A26C753D4E22

P3181

P356

P1433

Journal of Cell Biology

P1476

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

@en

P2093

Adam I Fogel

http://www.w3.org/2001/XMLSchema#string

Koji Yamano

http://www.w3.org/2001/XMLSchema#string

Lesley A Kane

http://www.w3.org/2001/XMLSchema#string

Richard J Youle

http://www.w3.org/2001/XMLSchema#string

Shireen A Sarraf

http://www.w3.org/2001/XMLSchema#string

Soojay Banerjee

http://www.w3.org/2001/XMLSchema#string

Yan Li

http://www.w3.org/2001/XMLSchema#string

P2860

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

PINK1 cleavage at position A103 by the mitochondrial protease PARL.

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy

The pathways of mitophagy for quality control and clearance of mitochondria

Structure of the human Parkin ligase domain in an autoinhibited state

P304

143-153

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

5685

http://www.w3.org/2001/XMLSchema#string

P356

10.1083/JCB.201402104

http://www.w3.org/2001/XMLSchema#string

P407

P433

2

http://www.w3.org/2001/XMLSchema#string

P478

205

http://www.w3.org/2001/XMLSchema#string

P50

Michael Lazarou

P577

2014-04-28T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

261769644

http://www.w3.org/2001/XMLSchema#string

P698

24751536

http://www.w3.org/2001/XMLSchema#string

P921

phosphorylation

P932

4003245

http://www.w3.org/2001/XMLSchema#string