BRCA2 is required for homology-directed repair of chromosomal breaks
about
Phosphorylation: the molecular switch of double-strand break repairDisruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation.BRCA2 and homologous recombinationHuman SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaksPurified human BRCA2 stimulates RAD51-mediated recombinationThe role of BRCA2 in replication-coupled DNA interstrand cross-link repair in vitroCDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repairEnhancement of RAD51 recombinase activity by the tumor suppressor PALB2.BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damageBRCA2 suppresses cell proliferation via stabilizing MAGE-D1Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeatsAbraxas and RAP80 form a BRCA1 protein complex required for the DNA damage responseHighlight: BRCA1 and BRCA2 proteins in breast cancerInteractions between human BRCA2 protein and the meiosis-specific recombinase DMC1Streamline proteomic approach for characterizing protein-protein interaction network in a RAD52 protein complexIdentification of functional domains in the RAD51L2 (RAD51C) protein and its requirement for gene conversionThe BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repairHomologous recombination: from model organisms to human disease.The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repairFunctional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistanceMediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchangeDeficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joiningPARP1 suppresses homologous recombination events in mice in vivoEme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cellsRational design of human DNA ligase inhibitors that target cellular DNA replication and repairATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2Comparative genomics and molecular dynamics of DNA repeats in eukaryotesRAD51 localization and activation following DNA damageRecombinational DNA Repair in Cancer and Normal Cells: The Challenge of Functional AnalysisHomologous Recombination and Its Role in CarcinogenesisDistinct functions of BRCA1 and BRCA2 in double-strand break repairGene conversion and deletion frequencies during double-strand break repair in human cells are controlled by the distance between direct repeatsNon-homologous end joining, but not homologous recombination, enables survival for cells exposed to a histone deacetylase inhibitor.Does tumorigenesis select for or against mutations of the DNA repair-associated genes BRCA2 and MRE11?: considerations from somatic mutations in microsatellite unstable (MSI) gastrointestinal cancers.The importance of BRCA1 and BRCA2 genes mutations in breast cancer developmentInterplay between Fanconi anemia and homologous recombination pathways in genome integrityOlaparib in the management of ovarian cancerExploiting the Fanconi Anemia Pathway for Targeted Anti-Cancer Therapy
P2860
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P2860
BRCA2 is required for homology-directed repair of chromosomal breaks
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
BRCA2 is required for homology-directed repair of chromosomal breaks
@ast
BRCA2 is required for homology-directed repair of chromosomal breaks
@en
type
label
BRCA2 is required for homology-directed repair of chromosomal breaks
@ast
BRCA2 is required for homology-directed repair of chromosomal breaks
@en
prefLabel
BRCA2 is required for homology-directed repair of chromosomal breaks
@ast
BRCA2 is required for homology-directed repair of chromosomal breaks
@en
P3181
P1433
P1476
BRCA2 is required for homology-directed repair of chromosomal breaks
@en
P2093
P304
P3181
P356
10.1016/S1097-2765(01)00174-5
P407
P577
2001-02-01T00:00:00Z