Locking the active conformation of c-Src kinase through the phosphorylation of the activation loop
about
Germinal-center kinase-like kinase co-crystal structure reveals a swapped activation loop and C-terminal extensionTowards a Molecular Understanding of the Link between Imatinib Resistance and Kinase Conformational DynamicsThe Activation of c-Src Tyrosine Kinase: Conformational Transition Pathway and Free Energy Landscape.Non-degradative Ubiquitination of Protein Kinases.Molecular dynamics of the proline switch and its role in Crk signaling.Dynamic, structural and thermodynamic basis of insulin-like growth factor 1 kinase allostery mediated by activation loop phosphorylation.Physicochemical mechanisms of protein regulation by phosphorylation.Dynamic architecture of a protein kinase.Activation pathway of Src kinase reveals intermediate states as targets for drug designHeat dissipation guides activation in signaling proteinsMolecular Dynamics Simulations and Classical Multidimensional Scaling Unveil New Metastable States in the Conformational Landscape of CDK2.E2 superfamily of ubiquitin-conjugating enzymes: constitutively active or activated through phosphorylation in the catalytic cleft.Molecular modeling and molecular dynamic simulation of the effects of variants in the TGFBR2 kinase domain as a paradigm for interpretation of variants obtained by next generation sequencing.An Allosteric Cross-Talk Between the Activation Loop and the ATP Binding Site Regulates the Activation of Src Kinase.Protein conformation as a regulator of cell-matrix adhesion.Identification of Aminoimidazole and Aminothiazole Derivatives as Src Family Kinase Inhibitors.Computational study of the W260A activating mutant of Src tyrosine kinase.Hsp90 dependence of a kinase is determined by its conformational landscapeDynamic Equilibrium of the Aurora A Kinase Activation Loop Revealed by Single-Molecule Spectroscopy.New insights into the structural dynamics of the kinase JNK3.Direct cysteine sulfenylation drives activation of the Src kinase
P2860
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P2860
Locking the active conformation of c-Src kinase through the phosphorylation of the activation loop
description
2013 nî lūn-bûn
@nan
2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Locking the active conformatio ...... ylation of the activation loop
@ast
Locking the active conformatio ...... ylation of the activation loop
@en
type
label
Locking the active conformatio ...... ylation of the activation loop
@ast
Locking the active conformatio ...... ylation of the activation loop
@en
prefLabel
Locking the active conformatio ...... ylation of the activation loop
@ast
Locking the active conformatio ...... ylation of the activation loop
@en
P2860
P3181
P1476
Locking the active conformatio ...... ylation of the activation loop
@en
P2093
Benoît Roux
Yilin Meng
P2860
P304
P3181
P356
10.1016/J.JMB.2013.10.001
P407
P577
2013-10-06T00:00:00Z