3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions - Wikidata - wikimedia - TriplyDB

3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions

3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions

http://www.wikidata.org/entity/Q30010273

about

Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism Claudin 18 is a novel negative regulator of bone resorption and osteoclast differentiation SH3 domains: modules of protein-protein interactions.The adaptor 3BP2 is required for KIT receptor expression and human mast cell survival Cherubism allele heterozygosity amplifies microbe-induced inflammatory responses in murine macrophages.Loss of SH3 domain-binding protein 2 function suppresses bone destruction in tumor necrosis factor-driven and collagen-induced arthritis in mice Etanercept administration to neonatal SH3BP2 knock-in cherubism mice prevents TNF-α-induced inflammation and bone loss.SH3BP2 cherubism mutation potentiates TNF-α-induced osteoclastogenesis via NFATc1 and TNF-α-mediated inflammatory bone loss.SH3BP2 gain-of-function mutation exacerbates inflammation and bone loss in a murine collagen-induced arthritis model Deletion of Orai1 alters expression of multiple genes during osteoclast and osteoblast maturation.Mesenchymal progenitors residing close to the bone surface are functionally distinct from those in the central bone marrow.RANKL coordinates multiple osteoclastogenic pathways by regulating expression of ubiquitin ligase RNF146.Early osteoblast responses to orthopedic implants: Synergy of surface roughness and chemistry of bioactive ceramic coating.Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2.Cloning and characterization of the human SH3BP2 promoter.Syk-dependent tyrosine phosphorylation of 3BP2 is required for optimal FcRγ-mediated phagocytosis and chemokine expression in U937 cells.Ubiquitin ligase RNF146 coordinates bone dynamics and energy metabolism.Enhanced TLR-MYD88 signaling stimulates autoinflammation in SH3BP2 cherubism mice and defines the etiology of cherubism.Protective effects of resveratrol on osteoporosis via activation of the SIRT1-NF-κB signaling pathway in rats.Osteoimmunology: The Conceptual Framework Unifying the Immune and Skeletal Systems.Dual-specificity tyrosine phosphorylation-regulated kinase 2 regulates osteoclast fusion in a cell heterotypic manner.Schlafen2 mutation in mice causes an osteopetrotic phenotype due to a decrease in the number of osteoclast progenitors Molecular and cellular characterizations of human cherubism: disease aggressiveness depends on osteoclast differentiation

P2860

Q24299210-D1B1501E-C2C2-438D-A3B9-D24943FD7F77 Q28589537-426DDF4F-91FB-4296-B6E0-A829106275B9 Q30008731-60735C1E-3137-4395-8C5F-774CA28DCDAD Q30009200-93AECFD0-FA18-4586-A483-54A04C324631 Q30009218-04DE9CB1-E254-4C3C-8929-7248BFAF043B Q30009262-D73439BA-0649-4CD1-8BE5-3ED58BD29D0B Q30009390-71F99E21-AB5A-4402-AD27-5D9955143FFC Q30009398-2BC2FD17-776A-40F6-A311-45E22F08B39D Q34075583-E0136828-AD9F-4CBF-A2A7-B30B5B102337 Q36438109-D0D420A2-1A72-4B10-B31C-9EFD50BAE129 Q36908369-F8EF1B5D-D239-4247-9C25-8171338767BA Q37730637-B2F1D637-5A6A-48D8-8CBD-AE21C11F8C55 Q38953365-75E4184F-58F4-4AFC-A159-A88BF3008F55 Q39232844-27E5BAF0-59AA-4138-B56D-58CF61928164 Q39310586-2679C518-9DD9-4B86-A106-A168D96DA8D5 Q41125333-20C5697E-D53D-4BE7-9309-6F797757B3EA Q41661724-1A2A3887-9538-4CF1-B851-B44BBCB34985 Q42918583-2552304B-1B0D-4036-A217-8FF855CAC83C Q47164485-D34A12C3-0730-4A32-963A-B4B6B3EB7982 Q47944184-51375585-DBDF-4C38-A5EA-03C29793130D Q48088472-FC09496D-0A15-4729-AEA3-55A2DA783D63 Q58695564-7E2544C3-815F-48E4-A6E9-B39E7B717C38 Q58711955-E4BEB1CB-E083-4A53-B02D-016BF9C3AC48

P2860

3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions

http://www.wikidata.org/entity/Q30010273

description

2011 nî lūn-bûn

@nan

2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions

@ast

3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions

@en

type

label

3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions

@ast

3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions

@en

prefLabel

3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions

@ast

3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions

@en

P1433

Q30010273-078848FD-9BCE-41B5-813A-A7993187839C

P1476

Q30010273-A990FDD8-DF98-46EC-956D-19110D2D0454

P2093

Q30010273-0F2E7E7D-9EEB-4DBC-8EB7-F8171920BA8F

Q30010273-376D754F-E046-4FFF-B4C3-BE6877FE39CA

Q30010273-489D0E9B-2273-4993-A95F-D0BA5129AD23

Q30010273-4B35F315-091A-4B0E-B664-2F0A6429E9CE

Q30010273-6BA75648-3D1E-4903-B1BB-A26A94D28BED

Q30010273-982FD745-468A-485C-8965-41E7A761BF72

Q30010273-CE3C64CA-A026-4D5C-886D-DE1A1EFBAC04

Q30010273-D008E8FE-1FB7-4BB7-8339-67B15AD285FE

Q30010273-DD8F059E-5749-465C-B4B1-6FDDE0CBD38B

Q30010273-E396A640-CCE4-4172-8E04-0D44FC3634A9

P2860

Q30010273-0344C980-D73E-435E-9F1C-9513156514E4

Q30010273-04141616-5B3E-4EE3-B94D-E3CC74E58BFE

Q30010273-0B76175D-CA0B-4F3C-9575-EF54F86965CA

Q30010273-0DD25985-51AB-4FE9-965F-98F2968089FB

Q30010273-14E37796-1F0D-4581-A1E8-8B30D94C6F3F

Q30010273-15FBD273-0799-4696-BCB8-8E6B97A36005

Q30010273-1A2847AA-5A8D-498C-980E-4FA50F5F362B

Q30010273-1BFB669C-02C6-42D5-BDE3-0DB70C27462E

Q30010273-1DD289F3-DC23-40FD-AD13-881DDAA13D77

Q30010273-1F202493-9C07-41B3-B136-5E0C4AD6F948

P304

Q30010273-3BD19552-8D1D-4152-95A7-7119E4D41233

P31

Q30010273-A1569862-640F-4D9D-BC3A-B19237D472AE

P356

Q30010273-63B0D122-D010-45DF-BE87-AAB538DC7168

P407

Q30010273-86A373AE-939E-46B2-A255-151B5ED7B723

P433

Q30010273-FC093974-4D14-44D8-B460-B57C2FD74FDB

P478

Q30010273-715727E7-FE02-4920-8457-E1ABFEB42D7C

P50

Q30010273-9FCEAFFD-14A8-4997-9319-51B4EB2F7E97

P577

Q30010273-4903FB96-F03C-44E0-8BD4-E1D15CC76774

P698

Q30010273-9D62A72F-0465-4972-AC6C-2EB08C97E240

P921

Q30010273-7142622F-83FD-49E0-A4C1-3FD31007291A

Q30010273-CABF5DD4-4F39-4985-B389-8297A48D32E3

P932

Q30010273-1F2AD7D6-B793-4E3F-8435-00C53C2FCDA1

P356

P1433

Journal of Clinical Investigation

P1476

3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions

@en

P2093

Adeline H M Ng

http://www.w3.org/2001/XMLSchema#string

Andrew Scotter

http://www.w3.org/2001/XMLSchema#string

Chiachien J Wang

http://www.w3.org/2001/XMLSchema#string

Ernst Reichenberger

http://www.w3.org/2001/XMLSchema#string

Ioannis D Dimitriou

http://www.w3.org/2001/XMLSchema#string

Jose La Rose

http://www.w3.org/2001/XMLSchema#string

Marc Grynpas

http://www.w3.org/2001/XMLSchema#string

Noam Levaot

http://www.w3.org/2001/XMLSchema#string

Paul D Simoncic

http://www.w3.org/2001/XMLSchema#string

Salima Janmohamed

http://www.w3.org/2001/XMLSchema#string

P2860

Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility

Src kinase activation by direct interaction with the integrin beta cytoplasmic domain

The adaptor protein 3BP2 associates with VAV guanine nucleotide exchange factors to regulate NFAT activation by the B-cell antigen receptor

Activation of extracellular signal-regulated kinase 2 by a novel Abl-binding protein, ST5

Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells

Differential regulation of TCR-mediated gene transcription by Vav family members

Structural basis for the autoinhibition of c-Abl tyrosine kinase

Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho

Dok-R binds c-Abl and regulates Abl kinase activity and mediates cytoskeletal reorganization

Regulation of Cbl phosphorylation by the Abl tyrosine kinase and the Nck SH2/SH3 adaptor

P304

3244-3257

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1172/JCI45843

http://www.w3.org/2001/XMLSchema#string

P407

P433

8

http://www.w3.org/2001/XMLSchema#string

P478

121

http://www.w3.org/2001/XMLSchema#string

P50

Robert Rottapel

P577

2011-07-18T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

21765218

http://www.w3.org/2001/XMLSchema#string

P921

P932

3148735

http://www.w3.org/2001/XMLSchema#string