about
Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubismStructural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism diseaseCkap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent mannerThe RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain.Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferationSuppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signalGrb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interactionThe MAGUK family protein CARD11 is essential for lymphocyte activationLfc and Tctex-1 regulate the genesis of neurons from cortical precursor cellsCherubism allele heterozygosity amplifies microbe-induced inflammatory responses in murine macrophages.Loss of SH3 domain-binding protein 2 function suppresses bone destruction in tumor necrosis factor-driven and collagen-induced arthritis in miceSH3BP2 cherubism mutation potentiates TNF-α-induced osteoclastogenesis via NFATc1 and TNF-α-mediated inflammatory bone loss.3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions3BP2 adapter protein is required for receptor activator of NFκB ligand (RANKL)-induced osteoclast differentiation of RAW264.7 cells.Adaptor function for the Syk kinases-interacting protein 3BP2 in IL-2 gene activation.Alpha4beta1 integrin mediates the recruitment of immature dendritic cells across the blood-brain barrier during experimental autoimmune encephalomyelitis.Intra-articular fms-like tyrosine kinase 3 ligand expression is a driving force in induction and progression of arthritis.Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancerThe Rho GTP exchange factor Lfc promotes spindle assembly in early mitosisHomeodomain-interacting protein kinase (HIPK)-1 is required for splenic B cell homeostasis and optimal T-independent type 2 humoral response.Essential gene profiles in breast, pancreatic, and ovarian cancer cells.Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.CaPSID: a bioinformatics platform for computational pathogen sequence identification in human genomes and transcriptomes.Regulation of cytokine receptor signaling by SOCS1.Cell surface profiling using high-throughput flow cytometry: a platform for biomarker discovery and analysis of cellular heterogeneity.Regulation of the immune system by SOCS family adaptor proteins.VHL: a very hip ligase.CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly.Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell deathThe adapter 3BP2: how it plugs into leukocyte signaling.The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor.Immune functions in mice lacking Clnk, an SLP-76-related adaptor expressed in a subset of immune cells.Putting out the fire: coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteins.A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilitiesGEF-H1 is necessary for neutrophil shear stress-induced migration during inflammation.The c-fms gene complements the mitogenic defect in mast cells derived from mutant W mice but not mi (microphthalmia) mice.RANKL coordinates multiple osteoclastogenic pathways by regulating expression of ubiquitin ligase RNF146.Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer.
P50
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P50
description
hulumtues
@sq
onderzoeker
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researcher
@en
հետազոտող
@hy
name
Robert Rottapel
@ast
Robert Rottapel
@en
Robert Rottapel
@es
Robert Rottapel
@nl
Robert Rottapel
@sl
type
label
Robert Rottapel
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Robert Rottapel
@en
Robert Rottapel
@es
Robert Rottapel
@nl
Robert Rottapel
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prefLabel
Robert Rottapel
@ast
Robert Rottapel
@en
Robert Rottapel
@es
Robert Rottapel
@nl
Robert Rottapel
@sl
P106
P1153
7004089740
P21
P31
P496
0000-0002-6024-5558