RIalpha subunit of PKA: a cAMP-free structure reveals a hydrophobic capping mechanism for docking cAMP into site B.
about
Crystal structure of Homo sapiens PTD012 reveals a zinc-containing hydrolase foldThe pharmacology of cyclic nucleotide-gated channels: emerging from the darknessNovel Isoform-Specific Interfaces Revealed by PKA RIIβ Holoenzyme StructuresCo-Crystal Structures of PKG Iβ (92–227) with cGMP and cAMP Reveal the Molecular Details of Cyclic-Nucleotide BindingImplementing Fluorescence Anisotropy Screening and Crystallographic Analysis to Define PKA Isoform-Selective Activation by cAMP AnalogsStructural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG IPKA RIα Homodimer Structure Reveals an Intermolecular Interface with Implications for Cooperative cAMP Binding and Carney Complex DiseaseDissecting the mechanism of Epac activation via hydrogen-deuterium exchange FT-IR and structural modeling.cAMP Modulation of the cytoplasmic domain in the HCN2 channel investigated by molecular simulations.Protein kinase A effects of an expressed PRKAR1A mutation associated with aggressive tumors.A generalized allosteric mechanism for cis-regulated cyclic nucleotide binding domains.Allosteric communication between cAMP binding sites in the RI subunit of protein kinase A revealed by NMRThe regulatory subunit of PKA-I remains partially structured and undergoes β-aggregation upon thermal denaturation.Cyclic AMP- and (Rp)-cAMPS-induced conformational changes in a complex of the catalytic and regulatory (RI{alpha}) subunits of cyclic AMP-dependent protein kinase.Dynamically driven ligand selectivity in cyclic nucleotide binding domains.Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα.Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A.Unidirectional allostery in the regulatory subunit RIα facilitates efficient deactivation of protein kinase A.Sensing domain dynamics in protein kinase A-I{alpha} complexes by solution X-ray scattering.Tapping the translation potential of cAMP signalling: molecular basis for selectivity in cAMP agonism and antagonism as revealed by NMR.The hinge region operates as a stability switch in cGMP-dependent protein kinase I alpha.Communication between tandem cAMP binding domains in the regulatory subunit of protein kinase A-Ialpha as revealed by domain-silencing mutations.A simple electrostatic switch important in the activation of type I protein kinase A by cyclic AMP.The conformationally dynamic C helix of the RIalpha subunit of protein kinase A mediates isoform-specific domain reorganization upon C subunit binding.cAMP-Dependent Protein Kinase and cGMP-Dependent Protein Kinase as Cyclic Nucleotide Effectors.An N-terminally truncated form of cyclic GMP-dependent protein kinase Iα (PKG Iα) is monomeric, autoinhibited, and provides a model for activation.Comparative thermodynamic analysis of cyclic nucleotide binding to protein kinase ARearrangements in a hydrophobic core region mediate cAMP action in the regulatory subunit of PKA
P2860
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P2860
RIalpha subunit of PKA: a cAMP-free structure reveals a hydrophobic capping mechanism for docking cAMP into site B.
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
RIalpha subunit of PKA: a cAMP ...... for docking cAMP into site B.
@ast
RIalpha subunit of PKA: a cAMP ...... for docking cAMP into site B.
@en
type
label
RIalpha subunit of PKA: a cAMP ...... for docking cAMP into site B.
@ast
RIalpha subunit of PKA: a cAMP ...... for docking cAMP into site B.
@en
prefLabel
RIalpha subunit of PKA: a cAMP ...... for docking cAMP into site B.
@ast
RIalpha subunit of PKA: a cAMP ...... for docking cAMP into site B.
@en
P2093
P1433
P1476
RIalpha subunit of PKA: a cAMP ...... for docking cAMP into site B.
@en
P2093
Nguyen-Huu Xuong
Simon Brown
Susan S Taylor
P304
P356
10.1016/J.STR.2004.03.022
P577
2004-06-01T00:00:00Z