CrkL mediates Ras-dependent activation of the Raf/ERK pathway through the guanine nucleotide exchange factor C3G in hematopoietic cells stimulated with erythropoietin or interleukin-3.
about
Neurotrophins: roles in neuronal development and functionPhosphorylated guanine nucleotide exchange factor C3G, induced by pervanadate and Src family kinases localizes to the Golgi and subcortical actin cytoskeletonTransformation of myeloid leukemia cells to cytokine independence by Bcr-Abl is suppressed by kinase-defective HckA yeast two-hybrid study of human p97/Gab2 interactions with its SH2 domain-containing binding partnersEngagement of the CrkL adaptor in interferon alpha signalling in BCR-ABL-expressing cellsCrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signalingRedundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclonSignalling to actin: role of C3G, a multitasking guanine-nucleotide-exchange factor.Tyrosine-phosphorylated SOCS3 interacts with the Nck and Crk-L adapter proteins and regulates Nck activation.Engagement of the CrkL adapter in interleukin-5 signaling in eosinophils.p130Cas scaffolds the signalosome to direct adaptor-effector cross talk during Kaposi's sarcoma-associated herpesvirus trafficking in human microvascular dermal endothelial cellsCardiovascular actions of neurotrophinsRole of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1.Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells.CD137 expression is induced by Epstein-Barr virus infection through LMP1 in T or NK cells and mediates survival promoting signals.Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers.EBV induces persistent NF-κB activation and contributes to survival of EBV-positive neoplastic T- or NK-cells.The SHP2-ERK2 signaling pathway regulates branched I antigen formation by controlling the binding of CCAAT/enhancer binding protein α to the IGnTC promoter region during erythroid differentiation.CRKL promotes lung cancer cell invasion through ERK-MMP9 pathway.Overexpression of CRKL correlates with malignant cell proliferation in breast cancer.CRKL overexpression promotes cell proliferation and inhibits apoptosis in endometrial carcinoma.Rap1 is activated by erythropoietin or interleukin-3 and is involved in regulation of beta1 integrin-mediated hematopoietic cell adhesion.Nerve growth factor-mediated neurite outgrowth via regulation of Rab5.Erythropoietin activates two distinct signaling pathways required for the initiation and the elongation of c-myc.Rac is activated by erythropoietin or interleukin-3 and is involved in activation of the Erk signaling pathway.
P2860
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P2860
CrkL mediates Ras-dependent activation of the Raf/ERK pathway through the guanine nucleotide exchange factor C3G in hematopoietic cells stimulated with erythropoietin or interleukin-3.
description
1999 nî lūn-bûn
@nan
1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
CrkL mediates Ras-dependent ac ...... ythropoietin or interleukin-3.
@ast
CrkL mediates Ras-dependent ac ...... ythropoietin or interleukin-3.
@en
type
label
CrkL mediates Ras-dependent ac ...... ythropoietin or interleukin-3.
@ast
CrkL mediates Ras-dependent ac ...... ythropoietin or interleukin-3.
@en
prefLabel
CrkL mediates Ras-dependent ac ...... ythropoietin or interleukin-3.
@ast
CrkL mediates Ras-dependent ac ...... ythropoietin or interleukin-3.
@en
P2093
P2860
P356
P1476
CrkL mediates Ras-dependent ac ...... ythropoietin or interleukin-3.
@en
P2093
P2860
P304
30154-30162
P356
10.1074/JBC.274.42.30154
P407
P577
1999-10-01T00:00:00Z