Intramolecular regulatory interactions in the Src family kinase Hck probed by mutagenesis of a conserved tryptophan residue.
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The unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate docking protein 1Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibitionRegulation of Ack1 localization and activity by the amino-terminal SAM domainStructural basis for the autoinhibition of focal adhesion kinaseComparative surface geometry of the protein kinase familyRole of the Brk SH3 domain in substrate recognitionAn analysis of protein domain linkers: their classification and role in protein foldingBiochemical properties of the Cdc42-associated tyrosine kinase ACK1. Substrate specificity, authphosphorylation, and interaction with HckThe Activation of c-Src Tyrosine Kinase: Conformational Transition Pathway and Free Energy Landscape.Subtle Dynamic Changes Accompany Hck Activation by HIV-1 Nef and are Reversed by an Antiretroviral Kinase Inhibitor.Cancer-Associated Mutations in Breast Tumor Kinase/PTK6 Differentially Affect Enzyme Activity and Substrate Recognition.SH2-catalytic domain linker heterogeneity influences allosteric coupling across the SFK family.Differential sensitivity of Src-family kinases to activation by SH3 domain displacement.Divergent modulation of Src-family kinase regulatory interactions with ATP-competitive inhibitors.The Cdc42-associated kinase ACK1 is not autoinhibited but requires Src for activation.Evidence for convergent evolution in the signaling properties of a choanoflagellate tyrosine kinaseThe evolutionarily conserved arrangement of domains in SRC family kinases is important for substrate recognition.An electrostatic network and long-range regulation of Src kinasesSignaling properties of a non-metazoan Src kinase and the evolutionary history of Src negative regulationCooperative activation of Src family kinases by SH3 and SH2 ligands.Conformational basis for SH2-Tyr(P)527 binding in Src inactivation.Activation of the Src family kinase Hck without SH3-linker release.An intramolecular interaction between SH2-kinase linker and kinase domain is essential for the catalytic activity of protein-tyrosine kinase-6.Structure and regulation of Src family kinases.Substrate conformational restriction and CD45-catalyzed dephosphorylation of tail tyrosine-phosphorylated Src protein.Molecular rulers: an assessment of distance and spatial relationships of Src tyrosine kinase Sh2 and active site regions.Reciprocal regulation of Hck activity by phosphorylation of Tyr(527) and Tyr(416). Effect of introducing a high affinity intramolecular SH2 ligand.SH2-kinase linker mutations release Hck tyrosine kinase and transforming activities in Rat-2 fibroblasts.A different function for a critical tryptophan in c-Raf and Hck.T-cell signaling regulated by the Tec family kinase, Itk.A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinaseStructural basis of the regulatory mechanism of the plant CIPK family of protein kinases controlling ion homeostasis and abiotic stressCellulase linkers are optimized based on domain type and function: insights from sequence analysis, biophysical measurements, and molecular simulation.Determinants of substrate recognition in nonreceptor tyrosine kinases.The Regulatory and Kinase Domains but Not the Interdomain Linker Determine Human Double-stranded RNA-activated Kinase (PKR) Sensitivity to Inhibition by Viral Non-coding RNAsBackbone dynamics in an intramolecular prolylpeptide-SH3 complex from the diphtheria toxin repressor, DtxR.The insulin and IGF1 receptor kinase domains are functional dimers in the activated state.αC helix as a switch in the conformational transition of Src/CDK-like kinase domains.Optimized bacterial expression and purification of the c-Src catalytic domain for solution NMR studies.Kinases and pseudokinases: lessons from RAF.
P2860
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P2860
Intramolecular regulatory interactions in the Src family kinase Hck probed by mutagenesis of a conserved tryptophan residue.
description
1998 nî lūn-bûn
@nan
1998 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Intramolecular regulatory inte ...... conserved tryptophan residue.
@ast
Intramolecular regulatory inte ...... conserved tryptophan residue.
@en
type
label
Intramolecular regulatory inte ...... conserved tryptophan residue.
@ast
Intramolecular regulatory inte ...... conserved tryptophan residue.
@en
prefLabel
Intramolecular regulatory inte ...... conserved tryptophan residue.
@ast
Intramolecular regulatory inte ...... conserved tryptophan residue.
@en
P2093
P2860
P356
P1476
Intramolecular regulatory inte ...... a conserved tryptophan residue
@en
P2093
M LaFevre-Bernt
W T Miller
P2860
P304
32129-32134
P356
10.1074/JBC.273.48.32129
P407
P577
1998-11-01T00:00:00Z