Activation of the Src family kinase Hck without SH3-linker release.
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Crystal Structure of the Src Family Kinase Hck SH3-SH2 Linker Regulatory Region Supports an SH3-dominant Activation MechanismActive site profiling reveals coupling between domains in SRC-family kinasesSubtle Dynamic Changes Accompany Hck Activation by HIV-1 Nef and are Reversed by an Antiretroviral Kinase Inhibitor.A Discovery Strategy for Selective Inhibitors of c-Src in Complex with the Focal Adhesion Kinase SH3/SH2-binding Region.SH2-catalytic domain linker heterogeneity influences allosteric coupling across the SFK family.Differential sensitivity of Src-family kinases to activation by SH3 domain displacement.Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry.Cooperative activation of Src family kinases by SH3 and SH2 ligands.On the importance of a funneled energy landscape for the assembly and regulation of multidomain Src tyrosine kinases.The Abl SH2-kinase linker naturally adopts a conformation competent for SH3 domain binding.C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases.Quantitative relation between intermolecular and intramolecular binding of pro-rich peptides to SH3 domains.Conformational basis for SH2-Tyr(P)527 binding in Src inactivation.An examination of dynamics crosstalk between SH2 and SH3 domains by hydrogen/deuterium exchange and mass spectrometry.Structural dynamic analysis of apo and ATP-bound IRAK4 kinaseExpression of a Src family kinase in chronic myelogenous leukemia cells induces resistance to imatinib in a kinase-dependent manner.Multidomain assembled states of Hck tyrosine kinase in solution.The influence of adnectin binding on the extracellular domain of epidermal growth factor receptor.Tyrosine 416 is phosphorylated in the closed, repressed conformation of c-Src.Structure and dynamic regulation of Abl kinases.An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad-spectrum Src family kinase inhibitor A-419259.Aberrant regulation and function of Src family tyrosine kinases: their potential contributions to glutamate-induced neurotoxicity.Computational study of the W260A activating mutant of Src tyrosine kinase.Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine.HIV-1 Nef inhibits lipopolysaccharide-induced IL-12p40 expression by inhibiting JNK-activated NFkappaB in human monocytic cells.A selective NMR probe to monitor the conformational transition from inactive to active kinase.Csk-homologous kinase (Chk/Matk): a molecular policeman suppressing cancer formation and progression
P2860
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P2860
Activation of the Src family kinase Hck without SH3-linker release.
description
2005 nî lūn-bûn
@nan
2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Activation of the Src family kinase Hck without SH3-linker release.
@ast
Activation of the Src family kinase Hck without SH3-linker release.
@en
type
label
Activation of the Src family kinase Hck without SH3-linker release.
@ast
Activation of the Src family kinase Hck without SH3-linker release.
@en
prefLabel
Activation of the Src family kinase Hck without SH3-linker release.
@ast
Activation of the Src family kinase Hck without SH3-linker release.
@en
P2093
P2860
P356
P1476
Activation of the Src family kinase Hck without SH3-linker release.
@en
P2093
Anthony P Schiavone
Edwina C Lerner
James M Hochrein
Ronald P Trible
Thomas E Smithgall
P2860
P304
40832-40837
P356
10.1074/JBC.M508782200
P407
P577
2005-10-06T00:00:00Z