Structure of human rhinovirus 3C protease reveals a trypsin-like polypeptide fold, RNA-binding site, and means for cleaving precursor polyprotein.
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A theoretical study of the active sites of papain and S195C rat trypsin: implications for the low reactivity of mutant serine proteinasesRoles of the Picornaviral 3C Proteinase in the Viral Life Cycle and Host CellsSharka: the past, the present and the futureActive residues and viral substrate cleavage sites of the protease of the birnavirus infectious pancreatic necrosis virus3C-like protease of rabbit hemorrhagic disease virus: identification of cleavage sites in the ORF1 polyprotein and analysis of cleavage specificityProcessing of the equine arteritis virus replicase ORF1b protein: identification of cleavage products containing the putative viral polymerase and helicase domainsThe NS3 proteinase domain of hepatitis C virus is a zinc-containing enzymeFunctional Characterization of the Cleavage Specificity of the Sapovirus Chymotrypsin-Like ProteaseStructure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypesStructure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain.Structural basis for the substrate specificity of tobacco etch virus proteaseCharacterization of a novel Ser-cisSer-Lys catalytic triad in comparison with the classical Ser-His-Asp triadDevelopment of Broad-Spectrum Halomethyl Ketone Inhibitors Against Coronavirus Main Protease 3CLproA Structural Study of Norovirus 3C Protease Specificity: Binding of a Designed Active Site-Directed Peptide InhibitorCrystal Structures of Enterovirus 71 3C Protease Complexed with Rupintrivir Reveal the Roles of Catalytically Important ResiduesBroad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronaviruses.Structural Basis for Antiviral Inhibition of the Main Protease, 3C, from Human Enterovirus 93Structure of a Murine Norovirus NS6 Protease-Product Complex Revealed by Adventitious CrystallisationThe crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme familiesThe refined crystal structure of the 3C gene product from hepatitis A virus: specific proteinase activity and RNA recognitionIn vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C proteaseInhibition of human rhinovirus-induced cytokine production by AG7088, a human rhinovirus 3C protease inhibitorPharmacokinetics and safety of an antirhinoviral agent, ruprintrivir, in healthy volunteersComparative Genetic Analyses of Human Rhinovirus C (HRV-C) Complete Genome from MalaysiaFunctional binding of hexanucleotides to 3C protease of hepatitis A virus.Characterization of Bafinivirus main protease autoprocessing activities.Characterization of a torovirus main proteinaseStructural genomics and its importance for gene function analysis.Norovirus protein structure and function.Overview of protein structural and functional folds.The picornaviral 3C proteinases: cysteine nucleophiles in serine proteinase folds.Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor.Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteersEnterovirus 71 3C protease cleaves a novel target CstF-64 and inhibits cellular polyadenylationStructural and energetic determinants of the S1-site specificity in serine proteases.Structural aspects of activation pathways of aspartic protease zymogens and viral 3C protease precursorsCleavage of the feline calicivirus capsid precursor is mediated by a virus-encoded proteinase.Mapping of the feline calicivirus proteinase responsible for autocatalytic processing of the nonstructural polyprotein and identification of a stable proteinase-polymerase precursor protein.Functional analysis of the interaction between VPg-proteinase (NIa) and RNA polymerase (NIb) of tobacco etch potyvirus, using conditional and suppressor mutants.Deletion mapping of the encephalomyocarditis virus primary cleavage site.
P2860
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P2860
Structure of human rhinovirus 3C protease reveals a trypsin-like polypeptide fold, RNA-binding site, and means for cleaving precursor polyprotein.
description
1994 nî lūn-bûn
@nan
1994 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Structure of human rhinovirus ...... leaving precursor polyprotein.
@ast
Structure of human rhinovirus ...... leaving precursor polyprotein.
@en
type
label
Structure of human rhinovirus ...... leaving precursor polyprotein.
@ast
Structure of human rhinovirus ...... leaving precursor polyprotein.
@en
prefLabel
Structure of human rhinovirus ...... leaving precursor polyprotein.
@ast
Structure of human rhinovirus ...... leaving precursor polyprotein.
@en
P2093
P1433
P1476
Structure of human rhinovirus ...... leaving precursor polyprotein.
@en
P2093
Budahazi G
Gribskov CL
Matthews DA
McElroy HE
Villafranca JE
P304
P356
10.1016/0092-8674(94)90059-0
P407
P577
1994-06-01T00:00:00Z