BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein.
about
Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to NckThe proximal signaling network of the BCR-ABL1 oncogene shows a modular organizationHierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptorThe phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptorThe product of the cbl oncogene forms stable complexes in vivo with endogenous Crk in a tyrosine phosphorylation-dependent mannerProtein tyrosine phosphatase 1B antagonizes signalling by oncoprotein tyrosine kinase p210 bcr-abl in vivo.The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signalingGrap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathwayRole of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesisRapid identification of phosphopeptide ligands for SH2 domains. Screening of peptide libraries by fluorescence-activated bead sortingCo-expression with BCR induces activation of the FES tyrosine kinase and phosphorylation of specific N-terminal BCR tyrosine residuesDirect interaction of Jak1 and v-Abl is required for v-Abl-induced activation of STATs and proliferationCharacterization of a novel member of the DOK family that binds and modulates Abl signalingA direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinaseStimulation of glycogen synthesis by insulin in human erythroleukemia cells requires the synthesis of glycosyl-phosphatidylinositolBinding of Vav to Grb2 through dimerization of Src homology 3 domainsTranscriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinasesTyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM-CSF, IL-3 and steel factor and is constitutively increased by p210BCR/ABLc-Abl kinase regulates the protein binding activity of c-CrkWiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cellsA DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/MTyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOSAssociation of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1Deregulation of p27 by oncogenic signaling and its prognostic significance in breast cancerChronic myeloid leukemia: reminiscences and dreamsMicroRNAs mediated regulation of MAPK signaling pathways in chronic myeloid leukemiaKinase-independent mechanisms of resistance of leukemia stem cells to tyrosine kinase inhibitorsCurrent concepts in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemiaSignal transduction in the chronic leukemias: implications for targeted therapiesCrystal structures of the Lyn protein tyrosine kinase domain in its Apo- and inhibitor-bound stateA potent and highly specific FN3 monobody inhibitor of the Abl SH2 domainStructural basis for specificity of Grb2-SH2 revealed by a novel ligand binding modeTransformation of myeloid leukemia cells to cytokine independence by Bcr-Abl is suppressed by kinase-defective HckCharacterization of a myeloid tyrosine phosphatase, Lyp, and its role in the Bcr-Abl signal transduction pathwayAssociation of Bcr-Abl with the proto-oncogene Vav is implicated in activation of the Rac-1 pathwayBCR/ABL-induced leukemogenesis causes phosphorylation of Hef1 and its association with CrklIntegrins regulate the association and phosphorylation of paxillin by c-AblDirect association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinaseTyrosine phosphorylation of Grb2 by Bcr/Abl and epidermal growth factor receptor: a novel regulatory mechanism for tyrosine kinase signaling.Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia
P2860
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P2860
BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein.
description
1993 nî lūn-bûn
@nan
1993 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
BCR-ABL-induced oncogenesis is ...... of the GRB-2 adaptor protein.
@ast
BCR-ABL-induced oncogenesis is ...... of the GRB-2 adaptor protein.
@en
type
label
BCR-ABL-induced oncogenesis is ...... of the GRB-2 adaptor protein.
@ast
BCR-ABL-induced oncogenesis is ...... of the GRB-2 adaptor protein.
@en
prefLabel
BCR-ABL-induced oncogenesis is ...... of the GRB-2 adaptor protein.
@ast
BCR-ABL-induced oncogenesis is ...... of the GRB-2 adaptor protein.
@en
P2093
P1433
P1476
BCR-ABL-induced oncogenesis is ...... of the GRB-2 adaptor protein.
@en
P2093
Bassing CH
Pendergast AM
Quilliam LA
Schlessinger J
P304
P356
10.1016/0092-8674(93)90689-N
P407
P577
1993-10-01T00:00:00Z