cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF beta-receptor.
about
Src-family tyrosine kinases in activation of ERK-1 and p85/p110-phosphatidylinositol 3-kinase by G/CCKB receptorsGTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunitPhosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulationControl of fibroblast growth factor receptor kinase signal transduction by heterodimerization of combinatorial splice variantsA tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1p70 phosphorylation and binding to p56lck is an early event in interleukin-2-induced onset of cell cycle progression in T-lymphocytesSpecific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activationInteraction of p85 subunit of PI 3-kinase with insulin and IGF-1 receptors analysed by using the two-hybrid systemIn vivo binding properties of SH2 domains from GTPase-activating protein and phosphatidylinositol 3-kinase1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cellsp110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytesPhosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivoThe SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signallingInteraction of the p85 subunit of PI 3-kinase and its N-terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changesSH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchangeFunctional cooperation of the interleukin-2 receptor beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylationExpression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression systemIdentification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast.Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutationIdentification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrewActivation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidylinositol 3-kinase upon B-cell antigen receptor-mediated signalingHigh-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domainsSignal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signalingEps8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signalsIdentification of c-erbB-3 binding sites for phosphatidylinositol 3'-kinase and SHC using an EGF receptor/c-erbB-3 chimeraPhosphorylation of Nck in response to a variety of receptors, phorbol myristate acetate, and cyclic AMPAssociation of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligandMultiple SH2-mediated interactions in v-src-transformed cells.Mutagenic analysis of the roles of SH2 and SH3 domains in regulation of the Abl tyrosine kinaseDirect association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 betaPhosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinaseCloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85Two species of human CRK cDNA encode proteins with distinct biological activitiesWiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domainsCrystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexesRole of the vav proto-oncogene product (Vav) in erythropoietin-mediated cell proliferation and phosphatidylinositol 3-kinase activityPhosphorylation of tyrosine 503 in the erythropoietin receptor (EpR) is essential for binding the P85 subunit of phosphatidylinositol (PI) 3-kinase and for EpR-associated PI 3-kinase activitySpecific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cblThe catalytic subunit of phosphatidylinositol 3-kinase is a substrate for the activated platelet-derived growth factor receptor, but not for middle-T antigen-pp60c-src complexesWortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction
P2860
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P2860
cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF beta-receptor.
description
1991 nî lūn-bûn
@nan
1991 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
cDNA cloning of a novel 85 kd ...... ase to the PDGF beta-receptor.
@ast
cDNA cloning of a novel 85 kd ...... ase to the PDGF beta-receptor.
@en
type
label
cDNA cloning of a novel 85 kd ...... ase to the PDGF beta-receptor.
@ast
cDNA cloning of a novel 85 kd ...... ase to the PDGF beta-receptor.
@en
prefLabel
cDNA cloning of a novel 85 kd ...... ase to the PDGF beta-receptor.
@ast
cDNA cloning of a novel 85 kd ...... ase to the PDGF beta-receptor.
@en
P2093
P1433
P1476
cDNA cloning of a novel 85 kd ...... ase to the PDGF beta-receptor.
@en
P2093
Escobedo JA
Kavanaugh WM
Navankasattusas S
Williams LT
P356
10.1016/0092-8674(91)90409-R
P407
P577
1991-04-01T00:00:00Z